Mitochondrial Perturbation in Alzheimer's Disease and Diabetes.

abstract：:Both genetic and environmental factors play roles in the development of refractive errors. Identification of genes involved in refractive errors may help in elucidating the underlying molecular mechanism related to both genetic defects and environmental pressure. Recent development of techniques for genome wide analys...

journal_title：Progress in molecular biology and translational science

authors： Zhang Q

更新日期：2015-01-01 00:00:00

abstract：:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy termin...

journal_title：Progress in molecular biology and translational science

authors： Moreno JL,Holloway T,González-Maeso J

更新日期：2013-01-01 00:00:00

abstract：:Experimental data accumulated during the last 10 years strongly support the existence and functional significance of oligomerization of G protein-coupled receptors (GPCRs). In this essay, we discuss the unique biochemical properties of GPCR oligomers in the frame of "allosterism" and how these properties can be used t...

journal_title：Progress in molecular biology and translational science

authors： Ferré S,Ciruela F,Casadó V,Pardo L

更新日期：2020-01-01 00:00:00

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:Cadherin-based cell-cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell-cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, operation of classical cadherin adhesion systems is coord...

journal_title：Progress in molecular biology and translational science

authors： Ratheesh A,Priya R,Yap AS

更新日期：2013-01-01 00:00:00

abstract：:Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic dev...

journal_title：Progress in molecular biology and translational science

authors： Ringvall M,Kjellén L

更新日期：2010-01-01 00:00:00

abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...

journal_title：Progress in molecular biology and translational science

authors： Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BK

更新日期：2020-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the leading cause of dementia and sixth cause of death in elderly adults. AD poses a huge economic burden on society and constitutes an unprecedented challenge for caregivers and families affected. Aging of the population is projected to drastically aggravate the situation in the near futur...

journal_title：Progress in molecular biology and translational science

authors： Di Meco A,Vassar R

更新日期：2021-01-01 00:00:00

abstract：:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review t...

journal_title：Progress in molecular biology and translational science

authors： Liu C,Jiao C,Wang K,Yuan N

更新日期：2018-01-01 00:00:00

abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...

journal_title：Progress in molecular biology and translational science

authors： Dunn EF,Connor JH

更新日期：2012-01-01 00:00:00

abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...

journal_title：Progress in molecular biology and translational science

authors： Nguyen PH,Sterpone F,Derreumaux P

更新日期：2020-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic. Different mechanisms have been proposed ...

journal_title：Progress in molecular biology and translational science

authors： Vancini R,Hernandez R,Brown D

更新日期：2015-01-01 00:00:00

abstract：:Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life events, such as childhood maltreatment, has been linked to...

journal_title：Progress in molecular biology and translational science

authors： Dick A,Provencal N

更新日期：2018-01-01 00:00:00

abstract：:The failure of neuropathic pain to abate even years after trauma suggests that adverse changes to synaptic function must exist in a chronic pathological state in nociceptive pathways. The chronicity of neuropathic pain therefore underscores the importance of understanding the contribution of dendritic spines--micron-s...

journal_title：Progress in molecular biology and translational science

authors： Tan AM

更新日期：2015-01-01 00:00:00

abstract：:Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. This pattern is likely...

journal_title：Progress in molecular biology and translational science

authors： Winters S,Martin C,Murphy D,Shokar NK

更新日期：2017-01-01 00:00:00

abstract：:Carbon nanotubes (CNTs) are cylinder-shaped allotropic forms of carbon, most widely produced under chemical vapor deposition. They possess astounding chemical, electronic, mechanical, and optical properties. Being among the most promising materials in nanotechnology, they are also likely to revolutionize medicine. Amo...

journal_title：Progress in molecular biology and translational science

authors： Gomez-Gualdrón DA,Burgos JC,Yu J,Balbuena PB

更新日期：2011-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00

abstract：:Guanine nucleotide-binding proteins of the inhibitory (Gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5HT1a, etc.). Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins. The redundant ...

journal_title：Progress in molecular biology and translational science

authors： Neubig RR

更新日期：2015-01-01 00:00:00

abstract：:Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This ch...

journal_title：Progress in molecular biology and translational science

authors： Silbergleit M,Vasquez AA,Miller CJ,Sun J,Kato I

更新日期：2020-01-01 00:00:00

abstract：:Single-molecule approaches permit an unrivalled view of how complex systems operate and have recently been used to understand DNA-protein interactions. These tools have enabled advances in a particularly challenging problem, the search for damaged sites on DNA. DNA repair proteins are present at the level of just a fe...

journal_title：Progress in molecular biology and translational science

authors： Kad NM,Van Houten B

更新日期：2012-01-01 00:00:00

abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...

journal_title：Progress in molecular biology and translational science

authors： Schorderet D

更新日期：2015-01-01 00:00:00

abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...

journal_title：Progress in molecular biology and translational science

authors： Lardenoije R,Pishva E,Lunnon K,van den Hove DL

更新日期：2018-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00

abstract：:Longitudinal growth results from multifactorial and complex processes that take place in the context of different genetic traits and environmental influences. Thus, in view of the difficulties in comprehension of the physiological mechanisms involved in the achievement of normal height, our ability to make a definitiv...

journal_title：Progress in molecular biology and translational science

authors： Fideleff HL,Boquete HR,Suárez MG,Azaretzky M

更新日期：2016-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...

journal_title：Progress in molecular biology and translational science

authors： Bohinc BN,Gesty-Palmer D

更新日期：2013-01-01 00:00:00

abstract：:Transition metals such as manganese are essential nutrients for both pathogen and host. Vertebrates exploit this necessity to combat invading microbes by restricting access to these critical nutrients, a defense known as nutritional immunity. During infection, the host uses several mechanisms to impose manganese limit...

journal_title：Progress in molecular biology and translational science

authors： Kelliher JL,Kehl-Fie TE

更新日期：2016-01-01 00:00:00

abstract：:Midbrain dopamine neurons are pacemakers in vitro, but in vivo they fire less regularly and occasionally in bursts that can lead to a temporary cessation in firing produced by depolarization block. The therapeutic efficacy of antipsychotic drugs used to treat the positive symptoms of schizophrenia has been attributed ...

journal_title：Progress in molecular biology and translational science

authors： Yu N,Tucker KR,Levitan ES,Shepard PD,Canavier CC

更新日期：2014-01-01 00:00:00

abstract：:Ribosomal protein S6 kinase (S6K) has been implicated in the phosphorylation of multiple substrates and is subject to activation by a wide variety of signals that converge at mammalian target of rapamycin (mTOR). In the course of the search for its physiological role, it was proposed that S6K activation and ribosomal ...

journal_title：Progress in molecular biology and translational science

authors： Meyuhas O,Dreazen A

更新日期：2009-01-01 00:00:00