abstract：:Alzheimer's disease (AD) is the leading cause of dementia and sixth cause of death in elderly adults. AD poses a huge economic burden on society and constitutes an unprecedented challenge for caregivers and families affected. Aging of the population is projected to drastically aggravate the situation in the near futur...

journal_title：Progress in molecular biology and translational science

authors： Di Meco A,Vassar R

更新日期：2021-01-01 00:00:00

abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...

journal_title：Progress in molecular biology and translational science

authors： Thorburn A

更新日期：2020-01-01 00:00:00

abstract：:Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This ch...

journal_title：Progress in molecular biology and translational science

authors： Silbergleit M,Vasquez AA,Miller CJ,Sun J,Kato I

更新日期：2020-01-01 00:00:00

abstract：:The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory ...

journal_title：Progress in molecular biology and translational science

authors： Racanelli AC,Choi AMK,Choi ME

更新日期：2020-01-01 00:00:00

abstract：:Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consistin...

journal_title：Progress in molecular biology and translational science

authors： Kuwata K

更新日期：2020-01-01 00:00:00

abstract：:Transmissible spongiform encephalopathies or prion diseases describe a number of different human disorders that differ in their clinical phenotypes, which are nonetheless united by their transmissible nature and common pathology. Clinical variation in the absence of a conventional infectious agent is believed to be en...

journal_title：Progress in molecular biology and translational science

authors： Ellett LJ,Revill ZT,Koo YQ,Lawson VA

更新日期：2020-01-01 00:00:00

abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...

journal_title：Progress in molecular biology and translational science

authors： Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BK

更新日期：2020-01-01 00:00:00

abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...

journal_title：Progress in molecular biology and translational science

authors： Bhopatkar AA,Uversky VN,Rangachari V

更新日期：2020-01-01 00:00:00

abstract：:Experimental data accumulated during the last 10 years strongly support the existence and functional significance of oligomerization of G protein-coupled receptors (GPCRs). In this essay, we discuss the unique biochemical properties of GPCR oligomers in the frame of "allosterism" and how these properties can be used t...

journal_title：Progress in molecular biology and translational science

authors： Ferré S,Ciruela F,Casadó V,Pardo L

更新日期：2020-01-01 00:00:00

abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...

journal_title：Progress in molecular biology and translational science

authors： Nguyen PH,Sterpone F,Derreumaux P

更新日期：2020-01-01 00:00:00

abstract：:Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease. PET imaging of neu...

journal_title：Progress in molecular biology and translational science

authors： Janssen B,Mach RH

更新日期：2019-01-01 00:00:00

abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...

journal_title：Progress in molecular biology and translational science

authors： Betthauser TJ

更新日期：2019-01-01 00:00:00

abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...

journal_title：Progress in molecular biology and translational science

authors： Wang X,Zhang R,Zhang L,Tian Z

更新日期：2019-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a glycoprotein and belongs to the gene family of serum albumins. The serum AFP levels were found to be elevated in the sera of liver cancer patients in 1964 and were subsequently developed and used as a liver cancer biomarker. However, elevated serum AFP levels have been observed in patients...

journal_title：Progress in molecular biology and translational science

authors： He Y,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:Four major types of biomacromolecules are nucleic acids (DNAs and RNAs), proteins, lipids, and glycans. Only carbohydrates or glycans are a universal existence in all types of the biomacromolecules. The monosaccharides deoxyribose and ribose are an integral part of DNA and RNA structures. Glycosylated proteins and gly...

journal_title：Progress in molecular biology and translational science

authors： Fu J,Wu Z,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Parkinson's disease (PD) devastates 6.3 million people, ranking it as one of the most prevalent neurodegenerative motor disorders worldwide. PD patients may manifest symptoms of postural instability, bradykinesia, and resting tremors as a result of increasing α-synuclein aggregation and neuron death with disease progr...

journal_title：Progress in molecular biology and translational science

authors： Shams R,Banik NL,Haque A

更新日期：2019-01-01 00:00:00

abstract：:Accumulating evidence showed that the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is an essential regulator of sexual development and reproduction from zebrafish to human. Activating and inactivating mutations of LHCGR gene have been identified from patients of different phenotypes. Familial male-limit...

journal_title：Progress in molecular biology and translational science

authors： Qiao J,Han B

更新日期：2019-01-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is commonly found in older people and in patients with Alzheimer's disease (AD) accompanying cerebrovascular disorders and dementia. Early-onset CAA cases generally have been found only in rare genetic forms of CAA. Interestingly, however, CAA-related hemorrhages have been recently re...

journal_title：Progress in molecular biology and translational science

authors： Yamada M,Hamaguchi T,Sakai K

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progressive loss of cognitive functions. Here we focus on the mechanisms in...

journal_title：Progress in molecular biology and translational science

authors： Loera-Valencia R,Ismail MA,Nilsson P,Winblad B

更新日期：2019-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Obesity contributes to the aging process through the alteration of metabolic pathways evidenced biochemically in the relationship between caloric restriction and longevity. Humans have entered into an era of metabolism and aging entirely unprecedented in their evolution, with a diet that, for many, contains a majority...

journal_title：Progress in molecular biology and translational science

authors： Bentley RA,Ross CN,O'Brien MJ

更新日期：2018-01-01 00:00:00

abstract：:In 1982, the Cech group discovered that an intron structure in an rRNA precursor of Tetrahymena thermophila is sufficient to complete splicing without assistance from proteins. This was the first moment that scientists recognized RNAs can have catalytic activities derived from their own unique three-dimensional struct...

journal_title：Progress in molecular biology and translational science

authors： Lee CH,Han SR,Lee SW

更新日期：2018-01-01 00:00:00

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...

journal_title：Progress in molecular biology and translational science

authors： Lardenoije R,Pishva E,Lunnon K,van den Hove DL

更新日期：2018-01-01 00:00:00

abstract：:Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life events, such as childhood maltreatment, has been linked to...

journal_title：Progress in molecular biology and translational science

authors： Dick A,Provencal N

更新日期：2018-01-01 00:00:00

abstract：:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review t...

journal_title：Progress in molecular biology and translational science

authors： Liu C,Jiao C,Wang K,Yuan N

更新日期：2018-01-01 00:00:00

abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...

journal_title：Progress in molecular biology and translational science

authors： Hoffman RM,Amoh Y

更新日期：2018-01-01 00:00:00

abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...

journal_title：Progress in molecular biology and translational science

authors： Alexander CM

更新日期：2018-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore...

journal_title：Progress in molecular biology and translational science

authors： Rabkin SW

更新日期：2017-01-01 00:00:00

abstract：:Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive role of mitochondria in cell function, mitochondrial dysfunction plays a part in many diseases, ...

journal_title：Progress in molecular biology and translational science

authors： Akhter F,Chen D,Yan SF,Yan SS

更新日期：2017-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00

abstract：:The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy individual. A wide range of transgenic models have been produced ranging from PrP...

journal_title：Progress in molecular biology and translational science

authors： Diack AB,Alibhai JD,Manson JC

更新日期：2017-01-01 00:00:00

abstract：:The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to re...

journal_title：Progress in molecular biology and translational science

authors： Salomon C,Rice GE

更新日期：2017-01-01 00:00:00

abstract：:Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. This pattern is likely...

journal_title：Progress in molecular biology and translational science

authors： Winters S,Martin C,Murphy D,Shokar NK

更新日期：2017-01-01 00:00:00

abstract：:Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators ...

journal_title：Progress in molecular biology and translational science

authors： Chen J,Khalil RA

更新日期：2017-01-01 00:00:00

abstract：:Over the past two decades, new technologies enabling targeted modification of plant genomes have been developed. Among these are zinc-finger nucleases (ZFNs) which are composed of engineered zinc-finger DNA-binding domains fused with a nuclease, generally the FokI nuclease. The zinc-finger domains are composed of a se...

journal_title：Progress in molecular biology and translational science

authors： Davies JP,Kumar S,Sastry-Dent L

更新日期：2017-01-01 00:00:00

abstract：:-1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon-anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical ...

journal_title：Progress in molecular biology and translational science

authors： Visscher K

更新日期：2016-01-01 00:00:00

abstract：:Transition metals such as manganese are essential nutrients for both pathogen and host. Vertebrates exploit this necessity to combat invading microbes by restricting access to these critical nutrients, a defense known as nutritional immunity. During infection, the host uses several mechanisms to impose manganese limit...

journal_title：Progress in molecular biology and translational science

authors： Kelliher JL,Kehl-Fie TE

更新日期：2016-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00