Hair Follicle-Associated Pluripotent(HAP) Stem Cells.

abstract：:The liver is the largest glandular organ in the body and plays a central role in controlling metabolism. During hepatogenesis, complex developmental processes must generate an array of cell types that are spatially arranged to generate a hepatic architecture that is essential to support liver function. The processes t...

journal_title：Progress in molecular biology and translational science

authors： Nagaoka M,Duncan SA

更新日期：2010-01-01 00:00:00

abstract：:The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and all...

journal_title：Progress in molecular biology and translational science

authors： Kitagawa Y,Wing JB,Sakaguchi S

更新日期：2015-01-01 00:00:00

abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...

journal_title：Progress in molecular biology and translational science

authors： Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BK

更新日期：2020-01-01 00:00:00

abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...

journal_title：Progress in molecular biology and translational science

authors： Nguyen PH,Sterpone F,Derreumaux P

更新日期：2020-01-01 00:00:00

abstract：:Over the last two centuries, the discovery and understanding of the principle of fluorescence have provided new means of characterizing physical/biological/chemical processes in a noninvasive manner. Fluorescence spectroscopy has become one of the most powerful and widely applied methods in the life sciences, from fun...

journal_title：Progress in molecular biology and translational science

authors： Deshayes S,Divita G

更新日期：2013-01-01 00:00:00

abstract：:Heterotrimeric G proteins convey receptor signals to intracellular effectors. Superimposed over the basic GPCR-G protein-effector scheme are three types of auxiliary proteins that also modulate Gα. Regulator of G protein signaling proteins and G protein signaling modifier proteins respectively promote GTPase activity ...

journal_title：Progress in molecular biology and translational science

authors： Zhao P,Cladman W,Van Tol HH,Chidiac P

更新日期：2013-01-01 00:00:00

abstract：:Longitudinal growth results from multifactorial and complex processes that take place in the context of different genetic traits and environmental influences. Thus, in view of the difficulties in comprehension of the physiological mechanisms involved in the achievement of normal height, our ability to make a definitiv...

journal_title：Progress in molecular biology and translational science

authors： Fideleff HL,Boquete HR,Suárez MG,Azaretzky M

更新日期：2016-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or autosomal-recessive forms of Parkinson's disease (PD), the second most common neurodegenerative disorder. Studies on the structural and functional properties of the corresponding gene products have provided significant insights into t...

journal_title：Progress in molecular biology and translational science

authors： Rochet JC,Hay BA,Guo M

更新日期：2012-01-01 00:00:00

abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...

journal_title：Progress in molecular biology and translational science

authors： Thorburn A

更新日期：2020-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore...

journal_title：Progress in molecular biology and translational science

authors： Rabkin SW

更新日期：2017-01-01 00:00:00

abstract：:Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consistin...

journal_title：Progress in molecular biology and translational science

authors： Kuwata K

更新日期：2020-01-01 00:00:00

abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...

journal_title：Progress in molecular biology and translational science

authors： Dunn EF,Connor JH

更新日期：2012-01-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is commonly found in older people and in patients with Alzheimer's disease (AD) accompanying cerebrovascular disorders and dementia. Early-onset CAA cases generally have been found only in rare genetic forms of CAA. Interestingly, however, CAA-related hemorrhages have been recently re...

journal_title：Progress in molecular biology and translational science

authors： Yamada M,Hamaguchi T,Sakai K

更新日期：2019-01-01 00:00:00

abstract：:Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. This pattern is likely...

journal_title：Progress in molecular biology and translational science

authors： Winters S,Martin C,Murphy D,Shokar NK

更新日期：2017-01-01 00:00:00

abstract：:DNA damage signaling and checkpoint control pathways are among the most commonly mutated networks in human tumors. Emerging data suggest that synthetic lethal interactions between mutated oncogenes or tumor suppressor genes with molecules involved in the DNA damage response and DNA repair pathways can be therapeutical...

journal_title：Progress in molecular biology and translational science

authors： Morandell S,Yaffe MB

更新日期：2012-01-01 00:00:00

abstract：:The worldwide epidemic of metabolic disease indicates that a better understanding of the pathways contributing to the pathogenesis of this constellation of diseases need to be determined. Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiatio...

journal_title：Progress in molecular biology and translational science

authors： Huang HJ,Schulman IG

更新日期：2009-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...

journal_title：Progress in molecular biology and translational science

authors： Roberts AP,Lewis AP,Jopling CL

更新日期：2011-01-01 00:00:00

abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...

journal_title：Progress in molecular biology and translational science

authors： Alexander CM

更新日期：2018-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elem...

journal_title：Progress in molecular biology and translational science

authors： Gurevich VV,Gurevich EV

更新日期：2013-01-01 00:00:00

abstract：:The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunctio...

journal_title：Progress in molecular biology and translational science

authors： Jia G,Aroor AR,Sowers JR

更新日期：2014-01-01 00:00:00

abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...

journal_title：Progress in molecular biology and translational science

authors： Schorderet D

更新日期：2015-01-01 00:00:00

abstract：:Skeletal muscle and white adipose tissue are the largest organs in the human body and both tissues act as endocrine organs capable of secreting many bioactive molecules. There has been some confusion about nomenclature and we suggest that the name myokine should be restricted to a protein or molecule secreted from myo...

journal_title：Progress in molecular biology and translational science

authors： Görgens SW,Eckardt K,Jensen J,Drevon CA,Eckel J

更新日期：2015-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also associated with several other diseases, such as obesity, hypertension, and cardiovascular diseases. Type 2 diabetes and obesity have become epidemic worldwide in the past few decades, and epidemiological and metabolic eviden...

journal_title：Progress in molecular biology and translational science

authors： Rachek LI

更新日期：2014-01-01 00:00:00

abstract：:Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and periph...

journal_title：Progress in molecular biology and translational science

authors： Fu L,Kettner NM

更新日期：2013-01-01 00:00:00

abstract：:Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may b...

journal_title：Progress in molecular biology and translational science

authors： Zhang X,Li JP

更新日期：2010-01-01 00:00:00

abstract：:Over the past two decades, new technologies enabling targeted modification of plant genomes have been developed. Among these are zinc-finger nucleases (ZFNs) which are composed of engineered zinc-finger DNA-binding domains fused with a nuclease, generally the FokI nuclease. The zinc-finger domains are composed of a se...

journal_title：Progress in molecular biology and translational science

authors： Davies JP,Kumar S,Sastry-Dent L

更新日期：2017-01-01 00:00:00

abstract：:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy termin...

journal_title：Progress in molecular biology and translational science

authors： Moreno JL,Holloway T,González-Maeso J

更新日期：2013-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00