Abstract：
:Cerebral amyloid angiopathy (CAA) is commonly found in older people and in patients with Alzheimer's disease (AD) accompanying cerebrovascular disorders and dementia. Early-onset CAA cases generally have been found only in rare genetic forms of CAA. Interestingly, however, CAA-related hemorrhages have been recently reported in younger people who had histories of neurosurgery with or without evidence of cadaveric dura mater grafts in childhood. It has been established in experimental settings that amyloid β-protein (Aβ) pathology can be transmitted inter-individually with Aβ seeds. Incidental Aβ pathology, predominantly Aβ-CAA, has been recognized in recipients of cadaveric dura mater grafts or cadaveric human growth hormone. These findings suggest that transmission of Aβ seeds through dura mater grafts and other contaminated materials could lead to development of CAA. In addition, neurosurgery or brain injury may contribute to cerebrovascular Aβ deposition through the disturbance of vascular Aβ drainage pathways. Thus, a novel concept, "acquired CAA," has emerged.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Yamada M,Hamaguchi T,Sakai Kdoi
10.1016/bs.pmbts.2019.05.012subject
Has Abstractpub_date
2019-01-01 00:00:00pages
85-95eissn
1877-1173issn
1878-0814pii
S1877-1173(19)30090-0journal_volume
168pub_type
杂志文章,评审abstract：:The Wnt family of secreted glycoproteins participates in a wide array of biological processes, including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis, hypertrophy, and aging. The canonical Wnt signaling primarily utilizes β-catenin-mediated activation of transcription, while the...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-398459-3.00007-1
更新日期：2012-01-01 00:00:00
abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2019.12.002
更新日期：2020-01-01 00:00:00
abstract：:Stem cell differentiation into a variety of lineages is known to involve signaling from the extracellular niche, including from the physical properties of that environment. What regulates stem cell responses to these cues is there ability to activate different mechanotransductive pathways. Here, we will review the str...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394624-9.00009-9
更新日期：2014-01-01 00:00:00
abstract：:Guanine nucleotide-binding proteins of the inhibitory (Gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5HT1a, etc.). Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins. The redundant ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.04.010
更新日期：2015-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is the leading cause of dementia and sixth cause of death in elderly adults. AD poses a huge economic burden on society and constitutes an unprecedented challenge for caregivers and families affected. Aging of the population is projected to drastically aggravate the situation in the near futur...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.10.002
更新日期：2021-01-01 00:00:00
abstract：:In eukaryotes, methylation of nucleosomal histones and other nuclear proteins is a central aspect of chromatin structure and dynamics. The past 15 years have seen an enormous advance in our understanding of the biochemistry of these modifications, and of their role in establishing the epigenetic code. We provide a syn...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/B978-0-12-387685-0.00004-4
更新日期：2011-01-01 00:00:00
abstract：:The complexity of memory formation and its persistence is a phenomenon that has been studied intensely for centuries. Memory exists in many forms and is stored in various brain regions. Generally speaking, memories are reorganized into broadly distributed cortical networks over time through systems level consolidation...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-420170-5.00005-2
更新日期：2014-01-01 00:00:00
abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.02.010
更新日期：2019-01-01 00:00:00
abstract：:The muscular dystrophies (MDs) represent a diverse collection of inherited human disorders, which affect to varying degrees skeletal, cardiac, and sometimes smooth muscle (Emery, 2002). To date, more than 50 different genes have been implicated as causing one or more types of MD (Bansal et al., 2003). In many cases, i...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394596-9.00004-4
更新日期：2012-01-01 00:00:00
abstract：:-1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon-anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.11.003
更新日期：2016-01-01 00:00:00
abstract：:The innate immune system senses microbial infections using pattern-recognition receptors and signals to activate adaptive immunity. Type I transmembrane protein Toll-like receptors (TLRs) play important roles in antimicrobial immune responses. Upon the recognition of pathogen-associated molecular patterns, TLRs homo- ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-386931-9.00018-0
更新日期：2013-01-01 00:00:00
abstract：:Skeletal muscle and white adipose tissue are the largest organs in the human body and both tissues act as endocrine organs capable of secreting many bioactive molecules. There has been some confusion about nomenclature and we suggest that the name myokine should be restricted to a protein or molecule secreted from myo...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.07.002
更新日期：2015-01-01 00:00:00
abstract：:Longitudinal growth results from multifactorial and complex processes that take place in the context of different genetic traits and environmental influences. Thus, in view of the difficulties in comprehension of the physiological mechanisms involved in the achievement of normal height, our ability to make a definitiv...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.10.009
更新日期：2016-01-01 00:00:00
abstract：:Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also associated with several other diseases, such as obesity, hypertension, and cardiovascular diseases. Type 2 diabetes and obesity have become epidemic worldwide in the past few decades, and epidemiological and metabolic eviden...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-800101-1.00008-9
更新日期：2014-01-01 00:00:00
abstract：:Experimental data accumulated during the last 10 years strongly support the existence and functional significance of oligomerization of G protein-coupled receptors (GPCRs). In this essay, we discuss the unique biochemical properties of GPCR oligomers in the frame of "allosterism" and how these properties can be used t...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.11.006
更新日期：2020-01-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2017.02.002
更新日期：2017-01-01 00:00:00
abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-415906-8.00002-9
更新日期：2011-01-01 00:00:00
abstract：:The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunctio...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394625-6.00009-X
更新日期：2014-01-01 00:00:00
abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2017.11.020
更新日期：2018-01-01 00:00:00
abstract：:The etiology of obesity is multifactorial, involving complex interactions among the genetic makeup, neuroendocrine status, fetal programming, and different unhealthy environmental factors, such as sedentarism or inadequate dietary habits. Among the different mechanisms causing obesity, epigenetics, defined as the stud...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-375003-7.00011-X
更新日期：2010-01-01 00:00:00
abstract：:The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to re...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.12.006
更新日期：2017-01-01 00:00:00
abstract：:High blood pressure (BP) is a complex trait determined by both genetic and environmental factors, as well as the interactions between these factors. Over the past few decades, there has been substantial progress in elucidating the genetic determinants underlying the BP response to sodium intake, or BP salt sensitivity...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-398397-8.00010-1
更新日期：2012-01-01 00:00:00
abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-396456-4.00002-X
更新日期：2012-01-01 00:00:00
abstract：:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review t...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2018.01.006
更新日期：2018-01-01 00:00:00
abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)86010-9
更新日期：2009-01-01 00:00:00
abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394440-5.00013-9
更新日期：2013-01-01 00:00:00
abstract：:Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and periph...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-396971-2.00009-9
更新日期：2013-01-01 00:00:00
abstract：:In this chapter, we describe how to create mathematical models of synaptic transmission and integration. We start with a brief synopsis of the experimental evidence underlying our current understanding of synaptic transmission. We then describe synaptic transmission at a particular glutamatergic synapse in the mammali...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-397897-4.00004-8
更新日期：2014-01-01 00:00:00
abstract：:The worldwide epidemic of metabolic disease indicates that a better understanding of the pathways contributing to the pathogenesis of this constellation of diseases need to be determined. Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiatio...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)87001-4
更新日期：2009-01-01 00:00:00
abstract：:Bacteriophage T4 is the archetype of virulent phage. It has evolved very efficient strategies to subvert host functions to its benefit and to impose the expression of its genome. T4 utilizes a combination of host and phage-encoded RNases and factors to degrade its mRNAs in a stage-dependent manner. The host endonuclea...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S0079-6603(08)00802-7
更新日期：2009-01-01 00:00:00
