-1 Programmed Ribosomal Frameshifting as a Force-Dependent Process.

abstract：:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns ...

journal_title：Progress in molecular biology and translational science

authors： Taneyhill LA,Schiffmacher AT

更新日期：2013-01-01 00:00:00

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...

journal_title：Progress in molecular biology and translational science

authors： Cook T,Zelhof A,Mishra M,Nie J

更新日期：2011-01-01 00:00:00

abstract：:Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity...

journal_title：Progress in molecular biology and translational science

authors： Sharif-Naeini R

更新日期：2015-01-01 00:00:00

abstract：:Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease. PET imaging of neu...

journal_title：Progress in molecular biology and translational science

authors： Janssen B,Mach RH

更新日期：2019-01-01 00:00:00

abstract：:In this chapter, we describe how to create mathematical models of synaptic transmission and integration. We start with a brief synopsis of the experimental evidence underlying our current understanding of synaptic transmission. We then describe synaptic transmission at a particular glutamatergic synapse in the mammali...

journal_title：Progress in molecular biology and translational science

authors： Rothman JS,Silver RA

更新日期：2014-01-01 00:00:00

abstract：:Both genetic and environmental factors play roles in the development of refractive errors. Identification of genes involved in refractive errors may help in elucidating the underlying molecular mechanism related to both genetic defects and environmental pressure. Recent development of techniques for genome wide analys...

journal_title：Progress in molecular biology and translational science

authors： Zhang Q

更新日期：2015-01-01 00:00:00

abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...

journal_title：Progress in molecular biology and translational science

authors： Ovcinnikovs V,Walker LS

更新日期：2015-01-01 00:00:00

abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...

journal_title：Progress in molecular biology and translational science

authors： Bhopatkar AA,Uversky VN,Rangachari V

更新日期：2020-01-01 00:00:00

abstract：:The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to re...

journal_title：Progress in molecular biology and translational science

authors： Salomon C,Rice GE

更新日期：2017-01-01 00:00:00

abstract：:Single-molecule approaches permit an unrivalled view of how complex systems operate and have recently been used to understand DNA-protein interactions. These tools have enabled advances in a particularly challenging problem, the search for damaged sites on DNA. DNA repair proteins are present at the level of just a fe...

journal_title：Progress in molecular biology and translational science

authors： Kad NM,Van Houten B

更新日期：2012-01-01 00:00:00

abstract：:Parkinson's disease (PD) devastates 6.3 million people, ranking it as one of the most prevalent neurodegenerative motor disorders worldwide. PD patients may manifest symptoms of postural instability, bradykinesia, and resting tremors as a result of increasing α-synuclein aggregation and neuron death with disease progr...

journal_title：Progress in molecular biology and translational science

authors： Shams R,Banik NL,Haque A

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutic...

journal_title：Progress in molecular biology and translational science

authors： Corbo CP,Alonso Adel C

更新日期：2011-01-01 00:00:00

abstract：:Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of...

journal_title：Progress in molecular biology and translational science

authors： Lane PJ,McConnell FM,Withers D,Gaspal F,Saini M,Anderson G

更新日期：2010-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00

abstract：:The liver is the largest glandular organ in the body and plays a central role in controlling metabolism. During hepatogenesis, complex developmental processes must generate an array of cell types that are spatially arranged to generate a hepatic architecture that is essential to support liver function. The processes t...

journal_title：Progress in molecular biology and translational science

authors： Nagaoka M,Duncan SA

更新日期：2010-01-01 00:00:00

abstract：:The complexity of memory formation and its persistence is a phenomenon that has been studied intensely for centuries. Memory exists in many forms and is stored in various brain regions. Generally speaking, memories are reorganized into broadly distributed cortical networks over time through systems level consolidation...

journal_title：Progress in molecular biology and translational science

authors： Santini E,Huynh TN,Klann E

更新日期：2014-01-01 00:00:00

abstract：:Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic. Different mechanisms have been proposed ...

journal_title：Progress in molecular biology and translational science

authors： Vancini R,Hernandez R,Brown D

更新日期：2015-01-01 00:00:00

abstract：:The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory ...

journal_title：Progress in molecular biology and translational science

authors： Racanelli AC,Choi AMK,Choi ME

更新日期：2020-01-01 00:00:00

abstract：:Stem cell differentiation into a variety of lineages is known to involve signaling from the extracellular niche, including from the physical properties of that environment. What regulates stem cell responses to these cues is there ability to activate different mechanotransductive pathways. Here, we will review the str...

journal_title：Progress in molecular biology and translational science

authors： Kaushik G,Engler AJ

更新日期：2014-01-01 00:00:00

abstract：:Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consistin...

journal_title：Progress in molecular biology and translational science

authors： Kuwata K

更新日期：2020-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...

journal_title：Progress in molecular biology and translational science

authors： Hayes DF,Smerage JB

更新日期：2010-01-01 00:00:00

abstract：:Heterotrimeric G proteins convey receptor signals to intracellular effectors. Superimposed over the basic GPCR-G protein-effector scheme are three types of auxiliary proteins that also modulate Gα. Regulator of G protein signaling proteins and G protein signaling modifier proteins respectively promote GTPase activity ...

journal_title：Progress in molecular biology and translational science

authors： Zhao P,Cladman W,Van Tol HH,Chidiac P

更新日期：2013-01-01 00:00:00

abstract：:DNA damage signaling and checkpoint control pathways are among the most commonly mutated networks in human tumors. Emerging data suggest that synthetic lethal interactions between mutated oncogenes or tumor suppressor genes with molecules involved in the DNA damage response and DNA repair pathways can be therapeutical...

journal_title：Progress in molecular biology and translational science

authors： Morandell S,Yaffe MB

更新日期：2012-01-01 00:00:00

abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...

journal_title：Progress in molecular biology and translational science

authors： Rampp C,Binder EB,Provençal N

更新日期：2014-01-01 00:00:00

abstract：:Genomic imprinting is the phenomenon where the expression of a locus differs between the maternally and paternally inherited alleles. Typically, this manifests as transcriptional silencing of one of the alleles, although many genes are imprinted in a tissue- or isoform-specific manner. Diseases associated with imprint...

journal_title：Progress in molecular biology and translational science

authors： Wilkins JF,Úbeda F

更新日期：2011-01-01 00:00:00

abstract：:The pituitary gonadotrope is central to reproductive function. Gonadotropes develop in a systematic process dependent on signaling factors secreted from surrounding tissues and those produced within the pituitary gland itself. These signaling pathways are important for stimulating specific transcription factors that u...

journal_title：Progress in molecular biology and translational science

authors： Stallings CE,Kapali J,Ellsworth BS

更新日期：2016-01-01 00:00:00

abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...

journal_title：Progress in molecular biology and translational science

authors： Dunn EF,Connor JH

更新日期：2012-01-01 00:00:00

abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...

journal_title：Progress in molecular biology and translational science

authors： Wang X,Zhang R,Zhang L,Tian Z

更新日期：2019-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00