Abstract：
:The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and allergy. It is therefore essential to understand the molecular mechanisms that make up Treg cell characteristics; that is, how their unique gene expression profile is regulated at transcriptional and epigenetic levels. In this chapter, we focus on the components of molecular features of Treg cells and discuss how they are introduced during their development.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Kitagawa Y,Wing JB,Sakaguchi Sdoi
10.1016/bs.pmbts.2015.07.011subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-33eissn
1877-1173issn
1878-0814pii
S1877-1173(15)00143-Xjournal_volume
136pub_type
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S0079-6603(08)00812-X
更新日期：2009-01-01 00:00:00
abstract：:Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity...
journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2009-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...
journal_title：Progress in molecular biology and translational science
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更新日期：2011-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
abstract：:Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This ch...
journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2014.10.002
更新日期：2015-01-01 00:00:00
abstract：:Both genetic and environmental factors play roles in the development of refractive errors. Identification of genes involved in refractive errors may help in elucidating the underlying molecular mechanism related to both genetic defects and environmental pressure. Recent development of techniques for genome wide analys...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.05.007
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-420170-5.00005-2
更新日期：2014-01-01 00:00:00
abstract：:Bacteriophage T4 is the archetype of virulent phage. It has evolved very efficient strategies to subvert host functions to its benefit and to impose the expression of its genome. T4 utilizes a combination of host and phage-encoded RNases and factors to degrade its mRNAs in a stage-dependent manner. The host endonuclea...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.04.023
更新日期：2020-01-01 00:00:00
abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.07.007
更新日期：2019-01-01 00:00:00
