Abstract：
:Workers experience large interindividual variability in exposure and biological response following exposure to chemicals. Quantitative methods to investigate occupational exposures and their relationship with biomarker levels, toxicokinetics of chemicals, and gene-environment interactions in disease development can be performed to unlock the black-box paradigm in exposure-disease associations. Exposure to a chemical at work is generally greater than that experienced in the wider environment. While inhalation exposure has traditionally been the main focus in exposure assessment, there is growing awareness of the significance of contact and uptake of chemicals through dermal and ingestion routes. Biological monitoring can provide information on exposure and uptake of a chemical, biological response to exposure, early subclinical changes, and susceptibility for disease. Thus, biomarkers can provide an important link between exposure and disease and may be an important tool for risk assessment. Integration of toxicology with exposure assessment, dose-response, and toxicogenomics can be used to improve one's understanding of exposure-disease relationships and shape risk assessment strategies to protect worker health.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Flack S,Nylander-French LAdoi
10.1016/B978-0-12-415813-9.00006-4subject
Has Abstractpub_date
2012-01-01 00:00:00pages
163-207eissn
1877-1173issn
1878-0814pii
B978-0-12-415813-9.00006-4journal_volume
112pub_type
杂志文章,评审abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...
journal_title：Progress in molecular biology and translational science
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abstract：:Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and periph...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...
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abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...
journal_title：Progress in molecular biology and translational science
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abstract：:Cannabis has been cultivated and used by humans for thousands of years. Research for decades was focused on understanding the mechanisms of an illegal/addictive drug. This led to the discovery of the vast endocannabinoid system. Research has now shifted to understanding fundamental biological questions related to one ...
journal_title：Progress in molecular biology and translational science
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更新日期：2016-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2014-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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abstract：:Both genetic and environmental factors play roles in the development of refractive errors. Identification of genes involved in refractive errors may help in elucidating the underlying molecular mechanism related to both genetic defects and environmental pressure. Recent development of techniques for genome wide analys...
journal_title：Progress in molecular biology and translational science
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abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...
journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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abstract：:Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progressive loss of cognitive functions. Here we focus on the mechanisms in...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-387685-0.00013-5
更新日期：2011-01-01 00:00:00
