Abstract：
:Escherichia coli contains a large number of suicide or toxin genes, whose expression leads to cell growth arrest and eventual cell death. One such toxin, MazF, is an ACA-specific endoribonuclease, termed "mRNA interferase."E. coli contains other mRNA interferases with different sequence specificities, which are considered to play important roles in growth regulation under stress conditions, and also in eliminating stress-damaged cells from a population. Recently, MazF homologues with 5-base recognition sequences have been identified, for example, those from Mycobacterium tuberculosis. These sequences are significantly underrepresented in the genes for protein families playing a role in the immunity and pathogenesis of M. tuberculosis. An mRNA interferase in Myxococcus xanthus is essential for programmed cell death during fruiting body formation. We propose that mRNA interferases play roles not only in cell growth regulation and programmed cell death, but also in regulation of specific gene expression (either positively or negatively) in bacteria.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Yamaguchi Y,Inouye Mdoi
10.1016/S0079-6603(08)00812-Xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
467-500eissn
1877-1173issn
1878-0814pii
S0079-6603(08)00812-Xjournal_volume
85pub_type
杂志文章,评审abstract：:The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.02.001
更新日期：2020-01-01 00:00:00
abstract：:Accumulating evidence showed that the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is an essential regulator of sexual development and reproduction from zebrafish to human. Activating and inactivating mutations of LHCGR gene have been identified from patients of different phenotypes. Familial male-limit...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is the leading cause of dementia and sixth cause of death in elderly adults. AD poses a huge economic burden on society and constitutes an unprecedented challenge for caregivers and families affected. Aging of the population is projected to drastically aggravate the situation in the near futur...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.10.002
更新日期：2021-01-01 00:00:00
abstract：:High blood pressure (BP) is a complex trait determined by both genetic and environmental factors, as well as the interactions between these factors. Over the past few decades, there has been substantial progress in elucidating the genetic determinants underlying the BP response to sodium intake, or BP salt sensitivity...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-398397-8.00010-1
更新日期：2012-01-01 00:00:00
abstract：:The etiology of obesity is multifactorial, involving complex interactions among the genetic makeup, neuroendocrine status, fetal programming, and different unhealthy environmental factors, such as sedentarism or inadequate dietary habits. Among the different mechanisms causing obesity, epigenetics, defined as the stud...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-375003-7.00011-X
更新日期：2010-01-01 00:00:00
abstract：:Bacteriophage T4 is the archetype of virulent phage. It has evolved very efficient strategies to subvert host functions to its benefit and to impose the expression of its genome. T4 utilizes a combination of host and phage-encoded RNases and factors to degrade its mRNAs in a stage-dependent manner. The host endonuclea...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S0079-6603(08)00802-7
更新日期：2009-01-01 00:00:00
abstract：:Guanine nucleotide-binding proteins of the inhibitory (Gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5HT1a, etc.). Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins. The redundant ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.04.010
更新日期：2015-01-01 00:00:00
abstract：:The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in terms of structure....
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-381286-5.00001-9
更新日期：2013-01-01 00:00:00
abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2018.09.001
更新日期：2018-01-01 00:00:00
abstract：:Skeletal muscle and white adipose tissue are the largest organs in the human body and both tissues act as endocrine organs capable of secreting many bioactive molecules. There has been some confusion about nomenclature and we suggest that the name myokine should be restricted to a protein or molecule secreted from myo...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.07.002
更新日期：2015-01-01 00:00:00
abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-415906-8.00002-9
更新日期：2011-01-01 00:00:00
abstract：:Antidepressant drugs remain poorly understood, especially with respect to pharmacological mechanisms of action. This lack of knowledge results from the extreme complexity inherent to psychopharmacology, as well as to a corresponding lack of knowledge regarding depressive disorder pathophysiology. While the final analy...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.03.007
更新日期：2015-01-01 00:00:00
abstract：:Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic. Different mechanisms have been proposed ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2014.10.002
更新日期：2015-01-01 00:00:00
abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.04.023
更新日期：2020-01-01 00:00:00
abstract：:In eukaryotes, methylation of nucleosomal histones and other nuclear proteins is a central aspect of chromatin structure and dynamics. The past 15 years have seen an enormous advance in our understanding of the biochemistry of these modifications, and of their role in establishing the epigenetic code. We provide a syn...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/B978-0-12-387685-0.00004-4
更新日期：2011-01-01 00:00:00
abstract：:Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2014.11.011
更新日期：2015-01-01 00:00:00
abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.06.001
更新日期：2020-01-01 00:00:00
abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.07.007
更新日期：2019-01-01 00:00:00
abstract：:Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(10)92007-3
更新日期：2010-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progressive loss of cognitive functions. Here we focus on the mechanisms in...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.07.003
更新日期：2019-01-01 00:00:00
abstract：:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the rol...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-397898-1.00005-0
更新日期：2014-01-01 00:00:00
abstract：:-1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon-anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.11.003
更新日期：2016-01-01 00:00:00
abstract：:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy termin...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-386931-9.00008-8
更新日期：2013-01-01 00:00:00
abstract：:Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.02.003
更新日期：2016-01-01 00:00:00
abstract：:Longitudinal growth results from multifactorial and complex processes that take place in the context of different genetic traits and environmental influences. Thus, in view of the difficulties in comprehension of the physiological mechanisms involved in the achievement of normal height, our ability to make a definitiv...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.10.009
更新日期：2016-01-01 00:00:00
abstract：:The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to re...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.12.006
更新日期：2017-01-01 00:00:00
abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.09.006
更新日期：2016-01-01 00:00:00
abstract：:The muscular dystrophies (MDs) represent a diverse collection of inherited human disorders, which affect to varying degrees skeletal, cardiac, and sometimes smooth muscle (Emery, 2002). To date, more than 50 different genes have been implicated as causing one or more types of MD (Bansal et al., 2003). In many cases, i...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394596-9.00004-4
更新日期：2012-01-01 00:00:00
abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394440-5.00013-9
更新日期：2013-01-01 00:00:00
abstract：:The failure of neuropathic pain to abate even years after trauma suggests that adverse changes to synaptic function must exist in a chronic pathological state in nociceptive pathways. The chronicity of neuropathic pain therefore underscores the importance of understanding the contribution of dendritic spines--micron-s...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2014.12.001
更新日期：2015-01-01 00:00:00
