Abstract：
:Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of the lymphotoxin beta receptor in these higher mammals was key to the development of these new functions. Here, we argue that lymphoid tissue inducer cells played a pivotal role not only in the development of organized lymphoid structures but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses that depend on an organized infrastructure to work. In this review, we concentrate on the role of this cell type in the making of a tolerant CD4 T cell repertoire and in the sustenance of CD4 T cell responses for protective immunity.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Lane PJ,McConnell FM,Withers D,Gaspal F,Saini M,Anderson Gdoi
10.1016/S1877-1173(10)92007-3subject
Has Abstractpub_date
2010-01-01 00:00:00pages
159-74eissn
1877-1173issn
1878-0814pii
S1877-1173(10)92007-3journal_volume
92pub_type
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