Abstract：
:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns throughout the development of an important vertebrate cell type, the neural crest. Multipotent neural crest cells arise from the ectoderm as epithelial cells under the influence of inductive cues, undergo an epithelial-to-mesenchymal transition, migrate throughout the embryonic body, and then differentiate into multiple derivatives at predetermined destinations. Neural crest cells change their expressed cadherin repertoires as they undergo each new morphogenetic transition, providing insight into distinct functions of expressed cadherins that are essential for proper completion of each specific stage. Cadherins modulate neural crest cell morphology, segregation, migration, and tissue formation. This chapter reviews the knowledge base of cadherin regulation, expression, and function during the ontogeny of the neural crest.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Taneyhill LA,Schiffmacher ATdoi
10.1016/B978-0-12-394311-8.00013-3subject
Has Abstractpub_date
2013-01-01 00:00:00pages
291-315eissn
1877-1173issn
1878-0814pii
B978-0-12-394311-8.00013-3journal_volume
116pub_type
杂志文章,评审abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...
journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
abstract：:Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the ...
journal_title：Progress in molecular biology and translational science
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abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...
journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2015-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(10)91004-1
更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2017.06.003
更新日期：2017-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)86010-9
更新日期：2009-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.02.004
更新日期：2020-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-396971-2.00009-9
更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)87001-4
更新日期：2009-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-397897-4.00011-5
更新日期：2014-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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doi：10.1016/B978-0-12-800101-1.00008-9
更新日期：2014-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.05.002
更新日期：2016-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-385233-5.00003-9
更新日期：2010-01-01 00:00:00
abstract：:Over the past two decades, new technologies enabling targeted modification of plant genomes have been developed. Among these are zinc-finger nucleases (ZFNs) which are composed of engineered zinc-finger DNA-binding domains fused with a nuclease, generally the FokI nuclease. The zinc-finger domains are composed of a se...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
abstract：:Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may b...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
abstract：:Cannabis has been cultivated and used by humans for thousands of years. Research for decades was focused on understanding the mechanisms of an illegal/addictive drug. This led to the discovery of the vast endocannabinoid system. Research has now shifted to understanding fundamental biological questions related to one ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.10.002
更新日期：2016-01-01 00:00:00
abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-800977-2.00002-4
更新日期：2014-01-01 00:00:00
abstract：:Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease. PET imaging of neu...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
abstract：:Heterotrimeric G proteins convey receptor signals to intracellular effectors. Superimposed over the basic GPCR-G protein-effector scheme are three types of auxiliary proteins that also modulate Gα. Regulator of G protein signaling proteins and G protein signaling modifier proteins respectively promote GTPase activity ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394587-7.00010-5
更新日期：2013-01-01 00:00:00
abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.04.004
更新日期：2015-01-01 00:00:00
abstract：:Parkinson's disease (PD) devastates 6.3 million people, ranking it as one of the most prevalent neurodegenerative motor disorders worldwide. PD patients may manifest symptoms of postural instability, bradykinesia, and resting tremors as a result of increasing α-synuclein aggregation and neuron death with disease progr...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.06.007
更新日期：2019-01-01 00:00:00
