Molecular Mechanisms of Cannabis Signaling in the Brain.

abstract：:Cell-surface receptors govern the critical information passage from outside to inside the cell and hence control important cellular decisions such as survival, growth, and differentiation. These receptors, structurally grouped into different families, utilize common intracellular signaling-proteins and pathways, yet p...

journal_title：Progress in molecular biology and translational science

authors： Girnita L,Takahashi SI,Crudden C,Fukushima T,Worrall C,Furuta H,Yoshihara H,Hakuno F,Girnita A

更新日期：2016-01-01 00:00:00

abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...

journal_title：Progress in molecular biology and translational science

authors： Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BK

更新日期：2020-01-01 00:00:00

abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...

journal_title：Progress in molecular biology and translational science

authors： Dunn EF,Connor JH

更新日期：2012-01-01 00:00:00

abstract：:In 1982, the Cech group discovered that an intron structure in an rRNA precursor of Tetrahymena thermophila is sufficient to complete splicing without assistance from proteins. This was the first moment that scientists recognized RNAs can have catalytic activities derived from their own unique three-dimensional struct...

journal_title：Progress in molecular biology and translational science

authors： Lee CH,Han SR,Lee SW

更新日期：2018-01-01 00:00:00

abstract：:The complexity of memory formation and its persistence is a phenomenon that has been studied intensely for centuries. Memory exists in many forms and is stored in various brain regions. Generally speaking, memories are reorganized into broadly distributed cortical networks over time through systems level consolidation...

journal_title：Progress in molecular biology and translational science

authors： Santini E,Huynh TN,Klann E

更新日期：2014-01-01 00:00:00

abstract：:Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration. The bis-retino...

journal_title：Progress in molecular biology and translational science

authors： Crouch RK,Koutalos Y,Kono M,Schey K,Ablonczy Z

更新日期：2015-01-01 00:00:00

abstract：:The muscular dystrophies (MDs) represent a diverse collection of inherited human disorders, which affect to varying degrees skeletal, cardiac, and sometimes smooth muscle (Emery, 2002). To date, more than 50 different genes have been implicated as causing one or more types of MD (Bansal et al., 2003). In many cases, i...

journal_title：Progress in molecular biology and translational science

authors： Ng R,Banks GB,Hall JK,Muir LA,Ramos JN,Wicki J,Odom GL,Konieczny P,Seto J,Chamberlain JR,Chamberlain JS

更新日期：2012-01-01 00:00:00

abstract：:Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators ...

journal_title：Progress in molecular biology and translational science

authors： Chen J,Khalil RA

更新日期：2017-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00

abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...

journal_title：Progress in molecular biology and translational science

authors： Ovcinnikovs V,Walker LS

更新日期：2015-01-01 00:00:00

abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...

journal_title：Progress in molecular biology and translational science

authors： Terzi D,Stergiou E,King SL,Zachariou V

更新日期：2009-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...

journal_title：Progress in molecular biology and translational science

authors： Roberts AP,Lewis AP,Jopling CL

更新日期：2011-01-01 00:00:00

abstract：:Cadherin-based cell-cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell-cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, operation of classical cadherin adhesion systems is coord...

journal_title：Progress in molecular biology and translational science

authors： Ratheesh A,Priya R,Yap AS

更新日期：2013-01-01 00:00:00

abstract：:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns ...

journal_title：Progress in molecular biology and translational science

authors： Taneyhill LA,Schiffmacher AT

更新日期：2013-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...

journal_title：Progress in molecular biology and translational science

authors： Hayes DF,Smerage JB

更新日期：2010-01-01 00:00:00

abstract：:Over the past two decades, new technologies enabling targeted modification of plant genomes have been developed. Among these are zinc-finger nucleases (ZFNs) which are composed of engineered zinc-finger DNA-binding domains fused with a nuclease, generally the FokI nuclease. The zinc-finger domains are composed of a se...

journal_title：Progress in molecular biology and translational science

authors： Davies JP,Kumar S,Sastry-Dent L

更新日期：2017-01-01 00:00:00

abstract：:Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elem...

journal_title：Progress in molecular biology and translational science

authors： Gurevich VV,Gurevich EV

更新日期：2013-01-01 00:00:00

abstract：:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the rol...

journal_title：Progress in molecular biology and translational science

authors： Bodelon C,Savage SA,Gadalla SM

更新日期：2014-01-01 00:00:00

abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...

journal_title：Progress in molecular biology and translational science

authors： Betthauser TJ

更新日期：2019-01-01 00:00:00

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:Globally, breast cancer is both the most commonly occurring cancer and the commonest cause of cancer death among women. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. This pattern is likely...

journal_title：Progress in molecular biology and translational science

authors： Winters S,Martin C,Murphy D,Shokar NK

更新日期：2017-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and all...

journal_title：Progress in molecular biology and translational science

authors： Kitagawa Y,Wing JB,Sakaguchi S

更新日期：2015-01-01 00:00:00

abstract：:Transmissible spongiform encephalopathies or prion diseases describe a number of different human disorders that differ in their clinical phenotypes, which are nonetheless united by their transmissible nature and common pathology. Clinical variation in the absence of a conventional infectious agent is believed to be en...

journal_title：Progress in molecular biology and translational science

authors： Ellett LJ,Revill ZT,Koo YQ,Lawson VA

更新日期：2020-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:The pituitary gonadotrope is central to reproductive function. Gonadotropes develop in a systematic process dependent on signaling factors secreted from surrounding tissues and those produced within the pituitary gland itself. These signaling pathways are important for stimulating specific transcription factors that u...

journal_title：Progress in molecular biology and translational science

authors： Stallings CE,Kapali J,Ellsworth BS

更新日期：2016-01-01 00:00:00

abstract：:The Wnt family of secreted glycoproteins participates in a wide array of biological processes, including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis, hypertrophy, and aging. The canonical Wnt signaling primarily utilizes β-catenin-mediated activation of transcription, while the...

journal_title：Progress in molecular biology and translational science

authors： Flaherty MP,Kamerzell TJ,Dawn B

更新日期：2012-01-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is commonly found in older people and in patients with Alzheimer's disease (AD) accompanying cerebrovascular disorders and dementia. Early-onset CAA cases generally have been found only in rare genetic forms of CAA. Interestingly, however, CAA-related hemorrhages have been recently re...

journal_title：Progress in molecular biology and translational science

authors： Yamada M,Hamaguchi T,Sakai K

更新日期：2019-01-01 00:00:00

abstract：:The failure of neuropathic pain to abate even years after trauma suggests that adverse changes to synaptic function must exist in a chronic pathological state in nociceptive pathways. The chronicity of neuropathic pain therefore underscores the importance of understanding the contribution of dendritic spines--micron-s...

journal_title：Progress in molecular biology and translational science

authors： Tan AM

更新日期：2015-01-01 00:00:00

abstract：:High blood pressure (BP) is a complex trait determined by both genetic and environmental factors, as well as the interactions between these factors. Over the past few decades, there has been substantial progress in elucidating the genetic determinants underlying the BP response to sodium intake, or BP salt sensitivity...

journal_title：Progress in molecular biology and translational science

authors： Kelly TN,He J

更新日期：2012-01-01 00:00:00