Abstract:
:Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutics is directed to cope with the symptoms of the disease. Here we describe the efforts dedicated to attack the plaques and, in more detail, the process of neurofibrillary degeneration, linked to the presence of the hyperphosphorylated microtubule associated protein tau. We have identified the different putative targets for therapeutics and the current knowledge on them.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Corbo CP,Alonso Adel Cdoi
10.1016/B978-0-12-385506-0.00002-8subject
Has Abstractpub_date
2011-01-01 00:00:00pages
47-83eissn
1877-1173issn
1878-0814pii
B978-0-12-385506-0.00002-8journal_volume
98pub_type
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