Tumor downstaging as an intermediate endpoint to assess the activity of neoadjuvant systemic therapy in patients with muscle-invasive bladder cancer.

abstract：BACKGROUND:A 59-year-old male developed intractable hiccups during monthly therapy with high dose dexamethasone for multiple myeloma. Hiccups would begin hours after his first dose and continue over the 4 days of therapy. He sought assistance after his attempt at home remedies failed and the hiccups became exhausting. ...

journal_title：Cancer

authors： Cersosimo RJ,Brophy MT

更新日期：1998-01-15 00:00:00

abstract：BACKGROUND:A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesi...

journal_title：Cancer

authors： Einspahr JG,Thomas TL,Saboda K,Nickolof BJ,Warneke J,Curiel-Lewandrowski C,Ranger-Moore J,Duckett L,Bangert J,Fruehauf JP,Alberts DS

更新日期：2007-12-01 00:00:00

abstract：:Two consecutive trials for the treatment of childhood non-Hodgkin's lymphoma were evaluated, carried out by the same cooperative groups. Group A: From June, 1973 to December, 1975, 50 evaluable patients under 16 years of age participated in a study that included vincristine and prednisone plus surgery and/or radiother...

journal_title：Cancer

authors： Sackmann-Muriel F,Diez B,Schvartzman E,Braier JL,Schwartz L,Gallo G,Pavlovsky S

更新日期：1984-12-15 00:00:00

abstract：BACKGROUND:Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-hour infusion. The maximum t...

journal_title：Cancer

authors： Blaney SM,Phillips PC,Packer RJ,Heideman RL,Berg SL,Adamson PC,Allen JC,Sallan SE,Jakacki RI,Lange BJ,Reaman GH,Horowitz ME,Poplack DG,Balis FM

更新日期：1996-08-01 00:00:00

abstract：:Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...

journal_title：Cancer

authors： Gerner RE,Moore GE

更新日期：1976-07-01 00:00:00

abstract：:Breast cancer is one of the most responsive of the common solid tumors when systemic therapy is indicated in the treatment of locally advanced or disseminated cancer. Many single agents have been useful in inducing remission in mammary carcinoma, but in recent years various drug combinations have been developed that a...

journal_title：Cancer

authors： Bisel HF

更新日期：1980-08-15 00:00:00

abstract：:A controlled trial of surgical adjuvant chemotherapy for breast cancer was carried out using 551 Japanese patients. Single or combined treatment with mitomycin C (0.2 mg/kg i.v. three times within five days postoperatively) and cyclophosphamide (100 mg postoperatively daily for four months or longer) was used after ra...

journal_title：Cancer

authors： Koyama H,Wada T,Takahashi Y,Nishizawa Y,Iwanaga T,Aoki Y,Terasawa T,Kosaki G,Kajita A,Wada A

更新日期：1980-12-01 00:00:00

abstract：:Sixty-six consecutive cases of carcinoma of the lower lip were seen at the Indiana University Hospitals from 1960 to 1972. Each patient's records were reviewed as to age, sex, race, stage, stage by treatment modality, pathology, treatment methods used and cause of failure. Early lip cancer represents a highly curative...

journal_title：Cancer

authors： Hornback NB,Shidnia H

更新日期：1978-01-01 00:00:00

abstract：:Stage IV-S neuroblastoma is a unique disseminated neoplasia characterized by remote disease to the liver, skin, or bone marrow. Stage IV-S patients have frequent spontaneous remissions and a 60% to 90% survival rate. Many investigators have recommended minimal or no therapeutic intervention; however, some patients do ...

journal_title：Cancer

authors： Stephenson SR,Cook BA,Mease AD,Ruymann FB

更新日期：1986-07-15 00:00:00

abstract：:Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

journal_title：Cancer

authors： Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

更新日期：1988-05-15 00:00:00

abstract：BACKGROUND:Studies regarding different ethnic populations of children with Wilms' tumor (WT) in the U. S. have shown differences between age and gender incidence and the type of its precursor lesions (nephrogenic rests). To the authors' knowledge there are few reports in the literature regarding nephrogenic rests in a ...

journal_title：Cancer

authors： Mishra K,Mathur M,Logani KB,Kakkar N,Krishna A

更新日期：1998-11-15 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to determine those prognostic factors associated with response to a second-line chemotherapy in patients with metastatic breast carcinoma (MBC) that was previously responsive to a first-line chemotherapy. METHODS:The 70 MBC patients studied had previously responded to...

journal_title：Cancer

authors： Brun B,Benchalal M,Lebas C,Piedbois P,Lin M,Lebourgeois JP

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:To the authors' knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. METHODS:The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologic slides were reviewed and fulfi...

journal_title：Cancer

authors： Cheng L,Cheville JC,Neumann RM,Leibovich BC,Egan KS,Spotts BE,Bostwick DG

更新日期：1999-06-01 00:00:00

abstract：:Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...

journal_title：Cancer

authors： Sherman DM,Neptune W,Weichselbaum R,Order SE,Piro AJ

更新日期：1978-05-01 00:00:00

abstract：:From April 1985 through March 1988, 24 lung cancer patients with carcinomatous pleuritis were treated with a new combined treatment modality consisting of pulmonary resection and postoperative intrathoracic chemo-thermotherapy (PICT). They consisted of 15 male patients and nine female patients. A majority of the patie...

journal_title：Cancer

authors： Kodama K,Doi O,Tatsuta M,Kuriyama K,Tateishi R

更新日期：1989-10-01 00:00:00

abstract：:The authors report a case of leiomyosarcoma in the mediastinum presenting with superior vena cava obstruction, and also demonstrate the aggressive nature of this tumor in spite of radiotherapy. Where technically feasible, surgery appears to be the treatment of choice. The pathologic and electron microscopic features o...

journal_title：Cancer

authors： Sunderrajan EV,Luger AM,Rosenholtz MJ,Maltby JD

更新日期：1984-06-01 00:00:00

abstract：:Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily. Usual side effects were mild sedation and dry mouth, but three patients found it ...

journal_title：Cancer

authors： Moertel CG,Kvols LK,Rubin J

更新日期：1991-01-01 00:00:00

abstract：:Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

journal_title：Cancer

authors： Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Ligand activation of peroxisome proliferator-activated receptor gamma (PPARgamma) results in the inhibition of proliferation of various cancer cells. The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglita...

journal_title：Cancer

authors： Yoshizawa K,Cioca DP,Kawa S,Tanaka E,Kiyosawa K

更新日期：2002-11-15 00:00:00

abstract：:A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental product...

journal_title：Cancer

authors： Cohen A,Geller SA,Horowitz I,Toth LS,Werther JL

更新日期：1984-03-01 00:00:00

abstract：:A pathology review of breast cancers in Japanese and Caucasian women indicates more numerous in situ carcinomas in the Japanese. Carcinomas with uniform nuclei were also more numerous among Japanese. Japanese women showed more extensive lymphocytic infiltrates adjacent to their tumors than did Caucasian women, and als...

journal_title：Cancer

authors： Stemmermann GN,Catts A,Fukunaga FH,Horie A,Nomura AM

更新日期：1985-07-01 00:00:00

abstract：:High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One ...

journal_title：Cancer

authors： Ambinder EP,Perloff M,Ohnuma T,Biller HF,Holland JF

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Assessment of prognostic markers in breast cancer independent of the axillary lymph node status is of major concern for the application of adjuvant treatment regimens. The current treatment decision is based mainly on the axillary lymph node status. Because of improved screening methods, the number and propo...

journal_title：Cancer

authors： Friedrichs K,Gluba S,Eidtmann H,Jonat W

更新日期：1993-12-15 00:00:00

abstract：:Clinical and laboratory data, histologic, electron microscopic and immunocytochemical findings of the tumors of eight patients suffering from Cushing's syndrome and of one patient with hypercalcemia are described. The unlabeled antibody enzyme method was used for the detection of insulin, glucagon, somatostatin, pancr...

journal_title：Cancer

authors： Heitz PU,Klöppel G,Polak JM,Staub JJ

更新日期：1981-11-01 00:00:00

abstract：:Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...

journal_title：Cancer

authors： Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

更新日期：1991-10-01 00:00:00

abstract：:In order to determine if there are morphologically identifiable characteristics between malignant cells obtained from a primary cancer and its metastasis the nuclear diameter was used as an indicator of the degree of malignancy, since there is good correlation between nuclear size, DNA content, and chromosome numbers....

journal_title：Cancer

authors： Zajdela A,Asselain B,Ghossein NA

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Questions have existed as to whether residential segregation is a mediator of racial/ethnic disparities in breast cancer care and breast cancer mortality, or has a differential effect by race/ethnicity. METHODS:Data from the Surveillance, Epidemiology, and End Results-Medicare database on white, black, and ...

journal_title：Cancer

authors： Haas JS,Earle CC,Orav JE,Brawarsky P,Keohane M,Neville BA,Williams DR

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODS:Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medica...

journal_title：Cancer

authors： Ailawadhi S,Frank RD,Sharma M,Menghani R,Temkit M,Paulus S,Khera N,Hashmi S,Advani P,Swaika A,Paulus A,Aslam N,Sher T,Roy V,Colon-Otero G,Chanan-Khan A

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:Cystic lesions of the adrenal gland are uncommon and demonstrate a spectrum of histologic changes and may vary from pseudocysts to malignant cystic neoplasms. METHODS:The authors analyzed a series of primary cystic lesions of the adrenal gland to evaluate the clinicopathologic features and histologic spectr...

journal_title：Cancer

authors： Erickson LA,Lloyd RV,Hartman R,Thompson G

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Re...

journal_title：Cancer

authors： van der Linden YM,Dijkstra SP,Vonk EJ,Marijnen CA,Leer JW,Dutch Bone Metastasis Study Group.

更新日期：2005-01-15 00:00:00