Abstract:
BACKGROUND:Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-hour infusion. The maximum tolerated dose was 5.5 mg/m2 and the dose-limiting toxicity was myelosuppression. This Phase II study of topotecan was performed to assess the activity of topotecan against childhood brain tumors. METHODS:Forty-five children with either a previously treated primary brain tumor that was refractory to standard therapy, or an untreated brain stem glioma or glioblastoma multiforme, received topotecan administered as a 24-hour intravenous infusion every 21 days. The initial dose was 5.5 mg/m2 with escalation to 7.5 mg/m2 on the second and subsequent doses in patients who did not experience dose-limiting toxicity. RESULTS:There were no complete or partial responses in the patients with high grade glioma (n=9), medulloblastoma (n=9), or brain stem glioma (n=14). One of 2 patients with a low grade glioma had a partial response lasting more than 17 months; 3 patients with a brain stem glioma had stable disease for 12 to 28 weeks; and 1 patient with a malignant neuroepithelial tumor and 1 patient with an optic glioma had stable disease for 41 weeks and 22 weeks, respectively. Dose escalation from 5.5 mg/m2 to 7.5 mg/m2 was well tolerated in the first 11 patients enrolled on this study who had not received prior craniospinal radiation therapy. The starting dose was subsequently increased to 7.5 mg/m2 for patients without prior craniospinal radiation. CONCLUSIONS:Topotecan administered as a 24-hour infusion every 21 days is inactive in high grade gliomas, medulloblastomas, and brain stem tumors.
journal_name
Cancerjournal_title
Cancerauthors
Blaney SM,Phillips PC,Packer RJ,Heideman RL,Berg SL,Adamson PC,Allen JC,Sallan SE,Jakacki RI,Lange BJ,Reaman GH,Horowitz ME,Poplack DG,Balis FMdoi
10.1002/(SICI)1097-0142(19960801)78:3<527::AID-CNCsubject
Has Abstractpub_date
1996-08-01 00:00:00pages
527-31issue
3eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960801)78:3<527::AID-CNCjournal_volume
78pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract::This report describes 11 adults with non-Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell ("histiocyt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<277::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract::Improvement in the management of acute leukemia in adults has not progressed nearly so rapidly as has the treatment of childhood leukemia. One important difference is that most adults have myeloblastic or related forms of the disease (AML), whereas the majority of children have lymphoblastic leukemia (ALL). However, e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<775::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Five-year survival rates after resection of liver metastases from colorectal carcinoma are close to 25%. Recurrences occur in two-thirds of the patients after surgery. Selection of patients likely to benefit from surgery remains controversial and subjective. METHODS:Data from 1568 patients with resected liv...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Paclitaxel currently is administered by prolonged intravenous infusion because of the occurrence of severe hypersensitivity reactions in patients in early clinical trials. However, intensive premedication probably is more important in eliminating allergic reactions than is the length of infusion. The authors...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19940815)74:4<1377::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract::The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28864
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of comm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33232
更新日期:2021-02-15 00:00:00
abstract:BACKGROUND:The Centers for Medicare and Medicaid Services (CMS) has released quality measures regarding potentially avoidable hospitalizations visits in the 30 days after receipt of outpatient chemotherapy. This study evaluated the proportions of patients treated by Medicare-reimbursed clinicians and Veterans Health Ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32896
更新日期:2020-07-15 00:00:00
abstract::Twenty-four patients who developed extramedullary disease during the course of Philadelphia chromosome-positive chronic myelogenous leukemia are described. The most frequent sites of extramedullary disease were lymph nodes (54%), bone (37%), and skin and soft tissue (29%). The appearance of extramedullary disease was ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870115)59:2<297::aid-cncr28205
更新日期:1987-01-15 00:00:00
abstract::Six patients with Hodgkin's disease (HD) and demonstrable serum antibodies to human immunodeficiency virus (HIV) and two additional patients with HD belonging to HIV-associated high-risk groups but with negative HIV serology were studied. All patients were men and ranged in age from 21 to 45 years. The HIV risk factor...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910401)67:7<1865::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Estimates of the fecal occult blood test (FOBT) (Hemoccult II) sensitivity differed widely between screening trials and led to divergent conclusions on the effects of FOBT screening. We used microsimulation modeling to estimate a preclinical colorectal cancer (CRC) duration and sensitivity for unrehydrated F...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24256
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Gastric carcinoma is one of the most common malignancies worldwide, with an overall survival of about 10%. Improvement in therapy awaits better understanding of the biologic behavior of this tumor. Establishment of cell lines permits detailed analysis of the biology of gastric cancer. The authors report on t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930801)72:3<649::aid-cncr28207
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990115)85:2<492::aid-cnc
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Prognostic implications of overexpression of the HER-2 gene in nonsmall cell lung carcinoma (NSCLC) are a matter of controversy. Many conflicting results have been reported from different laboratories. METHODS:A metaanalysis of published studies was performed for this quantitative review of the effects of H...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.20957
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distrib...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21840
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:Thalidomide is an antiangiogenic agent with immune modulating potential. The objective of this study was to determine response rates among women who were treated for recurrent ovarian cancer using topotecan with or without thalidomide. METHODS:Women were enrolled in this multicenter, prospective, randomized...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.23164
更新日期:2008-01-15 00:00:00
abstract::Prognostic factors were evaluated in 109 soft tissue sarcomas of the extremities, walls of the trunk, head, and neck. All lesions were graded according to the systems proposed by the National Cancer Institute (NCI) and the French Federation of Cancer Centers (FNCLCC), and a correlation was found between tumor grade an...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890401)63:7<1437::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Although flow cytometric DNA analysis has been recognized to be a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus, the biologic significance of DNA aneuploidy remains to be elucidated. METHODS:Twenty-five patients with squamous cell carcinoma of the esophagus who under...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::The ultrastructure of a human pineoblastoma is described. Tumor cells formed nests, palisading row and rosettes. Cells within nests were undifferentiated. Palisade and rosette forming cells had polarized cytoplasms and showed signs of differentiation and surface membrane specialization which included surface end-bulb-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1692::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<490::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract::We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This repres...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1439::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract::True adenomas of the breast are cellular epithelial lesions, which may be confused with carcinoma and are difficult to classify. We have reviewed 28 adenomas of the breast and have developed specific diagnostic criteria, as well as a classification of breast adenomas based on histologic features. Electron microscopic ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197606)37:6<2891::aid-cncr282037
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. METHODS:Eli...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.32057
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Because patients with germ cell tumors expect an additional life span of around 50 years after successful treatment, attention is now focused on potential long term toxicity. Limited data are available on Leydig cell function in long term survivors. METHODS:The authors measured testosterone, sex hormone bin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010401)91:7<1297::aid-cncr1132
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Cancer of the pancreas is a highly malignant illness with a very poor prognosis. Unfortunately, there has been little in the way of improvement in prognosis over the past 20 years. It is feared by patients because of its reputation as a deadly and often painful disease. Given these realities, it is not surpr...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0142(19960801)78:3<615::AID-CNC
更新日期:1996-08-01 00:00:00
abstract::Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cis-diamminedichloro platinum II in a Phase I-II trial. A safe starting dose of 120 mg/m2 was established. An overall response rate of 45% was noted with significant responses observed among patients with melanoma, sarco...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1278::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract::Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891201)64:11<2279::aid-cncr282
更新日期:1989-12-01 00:00:00
abstract::The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1090::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33105
更新日期:2020-11-01 00:00:00
abstract::Certain features of nodular sclerosing Hodgkin's disease predispose toward achievement of excellent radiotherapeutic results using clinical staging rather than currently advocated surgical staging including laparatomy. These include a distinct pattern of contiguous lymphatic involvement and the infrequent disseminatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1439::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract::Two hundred ninety-three patients with Stage IB carcinoma of the uterine cervix were treated by intracavitary irradiation followed by radical hysterectomy and pelvic lymph node dissection in the 3-year period 1970 to 1972, inclusive. Preoperative lymphography was performed and intraoperative films were taken to obtain...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841115)54:10<2215::aid-cncr282
更新日期:1984-11-15 00:00:00