Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy.

Abstract:

BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Response to radiotherapy and prognostic factors for survival were studied. METHODS:The data base of the Dutch Bone Metastasis Study was used. Response to treatment and prognostic factors for overall survival (OS) were studied using a Cox regression model. A scoring system was developed to predict OS. RESULTS:Responses were noted in 73% of patients. In 3% of patients, spinal cord compression was reported a mean of 3.5 months after randomization. The median OS was 7 months, and significant predictors for survival were Karnofsky performance score, primary tumor (multivariate analysis; both P < 0.001), and the absence of visceral metastases (multivariate analysis; P = 0.02). A scoring system based on these predictors was developed, and 34% of patients were in Group A (median OS = 3.0 months), 48% of patients were in Group B (median OS = 9.0 months), and 18% of patients were in Group C (median OS = 18.7 months). Group C was comprised of patients with breast carcinoma, a good performance, and no visceral metastases. CONCLUSIONS:Most patients with spinal metastases have a limited life expectancy and should be treated with caution regarding surgical procedures. Radiotherapy is a safe and effective, noninvasive treatment modality for pain. The new scoring system will enable physicians to select patients who may survive long enough to benefit from more radical treatment.

journal_name

Cancer

journal_title

Cancer

authors

van der Linden YM,Dijkstra SP,Vonk EJ,Marijnen CA,Leer JW,Dutch Bone Metastasis Study Group.

doi

10.1002/cncr.20756

subject

Has Abstract

pub_date

2005-01-15 00:00:00

pages

320-8

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

103

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CANCER文献大全
  • Gianturco expandable wire stents in the treatment of superior vena cava syndrome recurring after maximum-tolerance radiation.

    abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820

    authors: Rösch J,Bedell JE,Putnam J,Antonovic R,Uchida B

    更新日期:1987-09-15 00:00:00

  • A phase 2 study of cetuximab in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced nonsmall cell lung cancer.

    abstract:BACKGROUND:Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pharmacokinetics (PK). METHODS:Patients had evidence of epidermal growth factor receptor (EGFR) expression (> o...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.24148

    authors: Kim ES,Mauer AM,William WN Jr,Tran HT,Liu D,Lee JJ,Windt P,Hong WK,Vokes EE,Herbst RS

    更新日期:2009-04-15 00:00:00

  • Molecular targeting and pharmacogenomics in the management of advanced bladder cancer.

    abstract::Bladder cancer is one of the malignancies for which considerable information is available regarding molecular pathogenesis and genetic predictors of natural history, as well as response to treatment. Loss of heterozygosity of chromosome 9 appears to be essential to the genesis of superficial bladder cancer, and mutati...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11281

    authors: Raghavan D

    更新日期:2003-04-15 00:00:00

  • Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis.

    abstract:BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To impr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24893

    authors: Liggett T,Melnikov A,Yi QL,Replogle C,Brand R,Kaul K,Talamonti M,Abrams RA,Levenson V

    更新日期:2010-04-01 00:00:00

  • AANCART best practices: cancer awareness activities for Seattle's Combodian community.

    abstract::Census data indicate that Cambodian Americans are economically disadvantaged and linguistically isolated. In addition, cancer registry data show that Southeast Asians experience several cancer-related health disparities (e.g., markedly elevated risks of cervical and liver cancer). The Seattle regional Asian American N...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21515

    authors: Seng P,Acorda E,Carey Jackson J,Marchand A,Thai H,Tu SP,Taylor V

    更新日期:2005-12-15 00:00:00

  • A prospective evaluation of a triple-drug regimen containing cisplatin, vinblastine, and dacarbazine (CVD) for metastatic melanoma.

    abstract::Based on the independent activity of cisplatin, vinblastine, and dimethyl-triazeno-imidazole-carboxamide (DTIC) (CVD), a combination of these agents was used in the treatment of patients with advanced melanoma. Vinblastine was used in a dose of 1.6 mg/m2/d for 5 days, DTIC was used in a dose of 800 mg/m2 intravenously...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2024::aid-cncr282

    authors: Legha SS,Ring S,Papadopoulos N,Plager C,Chawla S,Benjamin R

    更新日期:1989-11-15 00:00:00

  • Transvaginal sonography as a screening method for ovarian cancer. A report of the first 1000 cases screened.

    abstract::From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<573::aid-cncr28206

    authors: van Nagell JR Jr,Higgins RV,Donaldson ES,Gallion HH,Powell DE,Pavlik EJ,Woods CH,Thompson EA

    更新日期:1990-02-01 00:00:00

  • Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes.

    abstract:BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33105

    authors: Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

    更新日期:2020-11-01 00:00:00

  • Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas.

    abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207

    authors: Uehara H,Nakaizumi A,Iishi H,Tatsuta M,Kitamra T,Okuda S,Ohigashi H,Ishikawa O,Takenaka A,Ishiguro S

    更新日期:1994-08-01 00:00:00

  • Clinicopathologic spectrum of resected extraductal mass-forming intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:The mode of tumor growth of intrahepatic cholangiocarcinoma (CC) varies considerably from patient to patient. This study describes the clinicopathologic variety of the extraductal mass-forming type of CC. METHODS:Patients with CC characterized by an extraductal mass (n = 26) who underwent hepatectomy from 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951215)76:12<2449::aid-cncr282

    authors: Yamanaka N,Okamoto E,Ando T,Oriyama T,Fujimoto J,Furukawa K,Tanaka T,Tanaka W,Nishigami T

    更新日期:1995-12-15 00:00:00

  • Risk-directed therapy for childhood acute lymphoblastic leukemia. Results of the Associazione Italiana Ematologia Oncologia Pediatrica '82 studies.

    abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19931015)72:8<2517::aid-cncr2820

    authors: Vecchi V,Aricò M,Basso G,Ceci A,Madon E,Mandelli F,Masera G,Massimo L,Pession A,Zanesco L

    更新日期:1993-10-15 00:00:00

  • Once weekly total and subtotal skin electron beam therapy for Kaposi's sarcoma.

    abstract::Although Kaposi's sarcoma (KS) usually appears with solitary skin lesions, in a large percentage of these patients the disease progresses eventually to involve large extensive segments of the skin. In the past, the most frequently used approach is the irradiation of isolated lesions as they arose, hence the so-called ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810215)47:4<640::aid-cncr28204

    authors: Nisce LZ,Safai B,Poussin-Rosillo H

    更新日期:1981-02-15 00:00:00

  • Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group.

    abstract:BACKGROUND:Clear cell sarcoma (CCS) of tendons and aponeuroses is extremely rare in childhood and little information is available on its clinical management. Originally believed to be a type of melanoma of soft tissue origin, CCS is now considered a distinct clinicopathologic entity that behaves like a high-grade soft ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10597

    authors: Ferrari A,Casanova M,Bisogno G,Mattke A,Meazza C,Gandola L,Sotti G,Cecchetto G,Harms D,Koscielniak E,Treuner J,Carli M

    更新日期:2002-06-15 00:00:00

  • Beta-benzene hexachloride in breast adipose tissue and risk of breast carcinoma.

    abstract:BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990515)85:10<2212::aid-c

    authors: Zheng T,Holford TR,Mayne ST,Owens PH,Ward B,Carter D,Dubrow R,Zahm SH,Boyle P,Tessari J

    更新日期:1999-05-15 00:00:00

  • An era of therapeutic translation.

    abstract::Diagnostic advances currently have exceeded therapeutic gain. The present, however, is a transition phase. Chemotherapy, for example, has become curative for some tumors in recent years, rather than merely palliative, due to the precision permitted by advances in molecular biology. At this time, acceleration in the ba...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)60:8+<1931::aid-cncr282

    authors: Gusberg SB

    更新日期:1987-10-15 00:00:00

  • Intramedullary hemangioblastoma of the spinal cord: definitive management with irradiation.

    abstract::A young woman with a very extensive intramedullary hemangioblastoma of the spinal cord was treated with a moderately high dose of irradiation after biopsy only of the tumor. Now, five years following treatment, there have been no radiation sequelae and no evidence of progressive disease. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800101)45:1<49::aid-cncr282045

    authors: Richardson RG,Griffin TW,Parker RG

    更新日期:1980-01-01 00:00:00

  • Potential impact on tumor control and organ preservation with cisplatin and 5-fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study.

    abstract:METHODS:Twelve patients with advanced epithelial nonadenocarcinoma of the paranasal sinuses and nasal fossa were treated with three cycles of cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1000 mg/m2/24 hours on days 1-5 by continuous infusion), followed by preoperative external radiation therapy of 48 Gy and limited...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19921201)70:11<2615::aid-cncr282

    authors: Björk-Eriksson T,Mercke C,Petruson B,Ekholm S

    更新日期:1992-12-01 00:00:00

  • Characterization of six cell lines established from human pancreatic adenocarcinomas.

    abstract:BACKGROUND:Six human pancreatic carcinoma cell lines, designated as KMP-1 to KMP-6, were established and maintained in vitro for > 3 years. All were derived from pancreatic ductal adenocarcinomas. The six cell lines originated from either primary pancreatic tumors, metastatic liver tumors, or metastases to lymph nodes....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990215)85:4<832::aid-cnc

    authors: Kato M,Shimada Y,Tanaka H,Hosotani R,Ohshio G,Ishizaki K,Imamura M

    更新日期:1999-02-15 00:00:00

  • Malignant peritoneal mesothelioma after remote abdominal radiation.

    abstract::Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19880515)61:10<2019::aid-cncr282

    authors: Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

    更新日期:1988-05-15 00:00:00

  • Stage I small cell carcinoma of the vulva treated with vulvectomy, lymphadenectomy, and adjuvant chemotherapy.

    abstract::Neuroendocrine small cell carcinoma is a lethal, but rare, tumor that arises most frequently in the lung. Small cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fourth reported case of neuroendocrine small cell carcinoma of the vulva. Previously, small cel...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19910501)67:9<2415::aid-cncr2820

    authors: Cliby W,Soisson AP,Berchuck A,Clarke-Pearson DL

    更新日期:1991-05-01 00:00:00

  • Isolated limb reperfusion with tumor necrosis factor and melphalan in patients with extremity melanoma after failure of isolated limb perfusion with chemotherapeutics.

    abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c

    authors: Bartlett DL,Ma G,Alexander HR,Libutti SK,Fraker DL

    更新日期:1997-12-01 00:00:00

  • Management of low-grade gliomas of the optic nerve and chiasm.

    abstract::Thirty-six patients were evaluated between 1965 and 1983 for glioma of the optic nerves and/or chiasm. Median follow-up was 10.2 years. Pathologic verification was obtained in 32 patients. Tumor initially confined to the optic nerve recurred in one of five patients after complete resection. The actuarial survival for ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880215)61:4<635::aid-cncr28206

    authors: Flickinger JC,Torres C,Deutsch M

    更新日期:1988-02-15 00:00:00

  • Retroperitoneal lymphadenectomy and aggressive chemotherapy in nonbulky clinical Stage II nonseminomatous germinal testis tumors.

    abstract::In a former series of 60 resected Stage II nonseminomatous germinal testis tumors the authors succeeded in demonstrating that adjuvant cisplatin, vinblastine, and bleomycin (PVB) was able to significantly improve survival (100% in 11 treated versus 28.5% in 7 historical controls, P less than 0.01) only in patients wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840315)53:6<1363::aid-cncr2820

    authors: Pizzocaro G,Zanoni F,Milani A,Piva L,Salvioni R,Pasi M,Pilotti S,Monfardini S

    更新日期:1984-03-15 00:00:00

  • Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.

    abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197811)42:5<2379::aid-cncr282042

    authors: Epstein AL,Levy R,Kim H,Henle W,Henle G,Kaplan HS

    更新日期:1978-11-01 00:00:00

  • Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor.

    abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26098

    authors: Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

    更新日期:2011-11-01 00:00:00

  • Olive oil, other seasoning fats, and the risk of colorectal carcinoma.

    abstract:BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/(sici)1097-0142(19980201)82:3<448::aid-cnc

    authors: Braga C,La Vecchia C,Franceschi S,Negri E,Parpinel M,Decarli A,Giacosa A,Trichopoulos D

    更新日期:1998-02-01 00:00:00

  • Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.

    abstract::Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intratheca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820

    authors: Brüstle O,Ohgaki H,Schmitt HP,Walter GF,Ostertag H,Kleihues P

    更新日期:1992-05-01 00:00:00

  • Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland.

    abstract::Five-hundred-eighteen cases of primary epithelial tumors of the parotid gland were examined. The incidence of carcinomas in pleomorphic adenoma was 9.3% (48 cases). In addition to cellular atypism, the following histological findings were thought to be important criteria for the diagnosis of carcinomas: (1) capsular i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810701)48:1<113::aid-cncr28204

    authors: Nagao K,Matsuzaki O,Saiga H,Sugano I,Shigematsu H,Kaneko T,Katoh T,Kitamura T

    更新日期:1981-07-01 00:00:00

  • Long-term follow-up of patients with newly diagnosed acute myeloid leukemia treated at the University of Texas M.D. Anderson Cancer Center.

    abstract:BACKGROUND:Chemotherapy is known to cure a small minority of patients with acute myeloid leukemia (AML). Less is known about the risk of such patients developing subsequent cancers or about their ability to return to work. METHODS:The authors analyzed outcomes among 1892 patients who received treatment for newly diagn...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971201)80:11+<2176::aid-

    authors: Estey E,deLima M,Strom S,Pierce S,Freireich EJ,Keating MJ

    更新日期:1997-12-01 00:00:00

  • Proliferative activity in primary breast carcinomas is a salient prognostic factor.

    abstract:BACKGROUND:The goal of the current study was to investigate the prognostic impact of proliferative activity, together with the other classic clinicopathologic prognostic factors (tumor size, tumor grade, receptor status, ploidy, and lymph node status), in breast carcinoma by counting mitoses and evaluating S phase frac...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11916

    authors: Michels JJ,Marnay J,Delozier T,Denoux Y,Chasle J

    更新日期:2004-02-01 00:00:00