Abstract:
:Five-hundred-eighteen cases of primary epithelial tumors of the parotid gland were examined. The incidence of carcinomas in pleomorphic adenoma was 9.3% (48 cases). In addition to cellular atypism, the following histological findings were thought to be important criteria for the diagnosis of carcinomas: (1) capsular invasion, (2) infiltration into adjacent organs, (3) proliferation of atypical cells within fibrous tissues and chondroid matrix in the area of pleomorphic adenoma, (4) vascular involvement, and (5) mitotic figures. Pleomorphic adenomas (282 cases) were found predominantly in females (70.8%), at the age of 30 to 49 (48.2%), whereas carcinomas in pleomorphic adenoma were more often found in males (70.8%) and at the ages over 50 (43.8%). Histologic types were composed mostly of undifferentiated carcinoma (56.2%) and adenocarcinoma (37.5%). The prognosis of the carcinomas, especially the undifferentiated type, was generally poor; about 45% of the cases either experienced recurrence or died within five years. Electron microscopy on this undifferentiated carcinoma revealed characteristic filamentous structure in the carcinoma cells, resembling that observed in myoepithelial cells. It was assumed that the undifferentiated carcinoma cells were of myoepithelial origin.
journal_name
Cancerjournal_title
Cancerauthors
Nagao K,Matsuzaki O,Saiga H,Sugano I,Shigematsu H,Kaneko T,Katoh T,Kitamura Tdoi
10.1002/1097-0142(19810701)48:1<113::aid-cncr28204subject
Has Abstractpub_date
1981-07-01 00:00:00pages
113-21issue
1eissn
0008-543Xissn
1097-0142journal_volume
48pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Multiple lymphomatous polyposis (MLP) results from gastrointestinal involvement by a B-cell lymphoma that originates from the mantle zone of lymphoid follicles. This well described clinicopathologic entity has a poor prognosis: the rate of complete response after conventional chemotherapy is very low. High d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950601)75:11<2742::aid-cncr282
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31871
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23238
更新日期:2008-02-15 00:00:00
abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract::Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<236::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...
journal_title:Cancer
pub_type: 杂志文章,收录出版,评审
doi:10.1002/cncr.24236
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract::The discovery that the human papilloma virus (HPV) is associated with a high and increasing percentage of oropharyngeal squamous cell carcinomas (SCCs) is among the most significant advances in the field of head and neck oncology. HPV-positive oropharyngeal cancer (HPVOPC) has clinical, etiologic, pathologic, and mole...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28595
更新日期:2014-05-15 00:00:00
abstract::A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197807)42:1<77::aid-cncr28204201
更新日期:1978-07-01 00:00:00
abstract::Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12<2557::aid-cncr282
更新日期:1980-12-15 00:00:00
abstract::The ability to noninvasively discriminate the most common types of renal cell carcinoma (RCC) based on their magnetic resonance imaging (MRI) appearances or their magnetic resonance phenotypes is achievable. Intracellular lipids, a histologic characteristic of the clear cell RCC, can be identified on chemical shift MR...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24237
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27401
更新日期:2012-09-01 00:00:00
abstract::The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2291::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990625)87:3<105::aid-cnc
更新日期:1999-06-25 00:00:00
abstract:BACKGROUND:This study aimed to examine disparities in survival and associated factors for patients with nonsmall-cell lung cancer (NSCLC) and to determine whether racial disparities varied over time (1991-1995, 1996-1999, and 2000-2002). METHODS:The authors studied 70,901 patients aged>or=65 years with stage I-IV NSCL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24521
更新日期:2009-10-15 00:00:00
abstract::Fifty patients with non resectable and/or inoperable bronchogenic carcinoma were entered into a feasibility study of cisplatin (CDDP) given in continuous infusion with concurrent radiation therapy. The radiation therapy regimen consisted of 2 Gy given 5 days a week in the first 3 and last 2 weeks of a 7-week split cou...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<357::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract:BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acqu...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.11009
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To impr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24893
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Shared decision-making (SDM) occurs when a patient partners with their oncologist to integrate personal preferences and values into treatment decisions. A key component of SDM is the elicitation of patient preferences and values, yet little is known about how and when these are elicited, communicated, priori...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32961
更新日期:2020-08-01 00:00:00
abstract::Radiation therapy alone, surgery alone, or the combination of these two modalities, remain the accepted treatments in the management of epidermoid carcinomas of the mucosa of the head and neck. These modalities of therapy produce comparable results; but, radiotherapy alone has the advantage that it can conserve anatom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850501)55:9+<2259::aid-cncr282
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Medullary thyroid carcinoma (MTC), a rare malignancy with a variety of morphologic appearances, can mimic both primary and metastatic lesions of the thyroid gland and give rise to diagnostic problems when these tumors are aspirated. Although cytopathologic features of MTC have been well described, this study...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-02-25 00:00:00
abstract::In contrast with the expectations of the authors and with reports suggesting a decline in risk for scrotal cancer, Connecticut Tumor Registry data neither showed detectable decrease in risk over the 45-year-period for all 95 scrotal malignancies nor for the 71 epithelial cancers. The age distribution of scrotal cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<596::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract::Twenty-four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic macromolecular drug, copoly(styrene-maleic acid) conjugated neocarzinostatin (SMANCS). The drug was dissolved in a lipid contrast medium Lipiodol and adminis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:11<2367::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. METHODS:A broad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32432
更新日期:2019-12-15 00:00:00
abstract:BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28766
更新日期:2014-09-01 00:00:00
abstract::A case of a hemangiopericytoma tumor metastatic to the lung from a central nervous system primary tumor in the posterior fossa is reported. The tumor was not responsive to treatment with cyclophosphamide, Adriamycin (doxorubicin), vincristine, DTIC (CYVADIC), high-dose methotrexate with citrovorum factor rescue, aziri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<916::aid-cncr28206
更新日期:1987-08-15 00:00:00
abstract::Twenty of 391 newly diagnosed cases of prostatic cancer (5%) had a prior prostatectomy for benign disease. Digital rectal examination in 16 of 19 patients (84%) revealed a significant prostatic abnormality. Continued serial digital rectal examination should be performed routinely after prostatectomy for benign disease...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860815)58:4<994::aid-cncr28205
更新日期:1986-08-15 00:00:00
abstract:BACKGROUND:Antithymocyte globulin (ATG) is an important component of conditioning regimens to prevent severe graft-versus-host disease (GVHD) in patients undergoing unmanipulated, haploidentical stem cell transplantation (haplo-SCT). However, to the authors' knowledge, the optimal dose of ATG is unknown. METHODS:In th...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.30540
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss of E2 function is considered a key step in carcinogenesis. Integration of HPV into the host genome may disrupt the E2 gene. Furthermore, methylation of CpG dinucleotides in E2-binding sites (E2BSs) in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29315
更新日期:2015-06-15 00:00:00