Abstract:
:Fifty patients with non resectable and/or inoperable bronchogenic carcinoma were entered into a feasibility study of cisplatin (CDDP) given in continuous infusion with concurrent radiation therapy. The radiation therapy regimen consisted of 2 Gy given 5 days a week in the first 3 and last 2 weeks of a 7-week split course (50 Gy of total dose). The CDDP (daily dose of 4 to 6 mg/m2) was administered to cover the days of radiation treatment by means of a central venous catheter and a portable pump. Less than 1% of predicted duration of infusion was lost due to complications related to venous access and pump. Toxicity was moderate. The overall probability of a locoregional major response (complete + partial) within 1 month after treatment completion was 86%. Twenty-three patients underwent resection. The 1-year actuarial probability of survival was 64%. The high response and survival rates warrant further studies on concurrent CDDP continuous infusion and radiation therapy in inoperable lung carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
Bedini AV,Tavecchio L,Milani F,Gramaglia A,Spreafico C,Marchianò A,Ravasi Gdoi
10.1002/1097-0142(19910115)67:2<357::aid-cncr28206subject
Has Abstractpub_date
1991-01-15 00:00:00pages
357-62issue
2eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
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