Abstract:
:The effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Multimodal immune manipulation consisted of combinations of splenectomy, C. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. Such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. Ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with normal rabbit serum died of progressive tumor growth. None of the rats treated with combinations of splenectomy, unblocking serum, unblocked lymphoid cells, C. parvum and levamisole succumbed to progressive tumor growth during the observation period. The histologic evidence of tumor destruction was obtained in 18 of 22 tumors in rats of groups receiving multimodal immunotherapy.
journal_name
Cancerjournal_title
Cancerauthors
Bansal BR,Mobini J,Bansal SCdoi
10.1002/1097-0142(197811)42:5<2079::aid-cncr282042subject
Has Abstractpub_date
1978-11-01 00:00:00pages
2079-96issue
5eissn
0008-543Xissn
1097-0142journal_volume
42pub_type
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