Abstract:
BACKGROUND:The authors investigated how lymphopenia and low serum albumin levels correlate with the prognosis of patients with carcinoma of unknown primary (CUP). METHODS:Univariate and multivariate prognostic factor analyses were conducted in a population of 317 consecutive patients with CUP who were evaluated at the Cross Cancer Institute of Edmonton, Alberta, Canada, from 1998 to 2004. RESULTS:The results from multivariate analysis showed that patients who had a performance status >/=2 (using the World Health Organization scale), a high overall comorbidity score (on the Adult Comorbidity Evaluation 27), liver metastasis, elevated serum lactate dehydrogenase (LDH) levels, lymphopenia (defined as an absolute lymphocyte count >/=0.7 x 10(9)/L), and low serum albumin levels had a worse prognosis. Based on the observation that the presence of liver metastasis and low serum albumin levels were the most powerful adverse prognostic factors, a classification scheme was delineated that took those 2 variables into account. A group of good-risk patients (no liver metastasis and normal serum albumin levels) and a group of poor-risk patients (liver metastasis and/or low serum albumin levels) were identified with median survivals of 371 days and 103 days, respectively (P < .0001). This classification was validated further in an independent data set of 124 patients who were evaluated at 2 French cancer centers: Among those patients, the median survival was 378 days in the good-risk group and 90 days in the poor-risk group (P < .0001). The new prognostic model substantially outperformed the previous standard prognostic model, which was based on performance status and serum LDH levels. CONCLUSIONS:Lymphopenia and low serum albumin levels were identified as 2 new independent markers of prognosis in patients with CUP. Although the authors confirmed the validity of the previous prognostic model, they developed and validated a more powerful, simple model based on the 2 most powerful adverse prognostic factors: liver metastasis and low serum albumin levels. These findings were confirmed in an independent cohort of patients with CUP, and consideration of the authors' improved prognostic model for survival of patients with CUP is warranted.
journal_name
Cancerjournal_title
Cancerauthors
Seve P,Ray-Coquard I,Trillet-Lenoir V,Sawyer M,Hanson J,Broussolle C,Negrier S,Dumontet C,Mackey JRdoi
10.1002/cncr.22300subject
Has Abstractpub_date
2006-12-01 00:00:00pages
2698-705issue
11eissn
0008-543Xissn
1097-0142journal_volume
107pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010601)91:11<2016::aid-cncr122
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract:BACKGROUND:This study was performed to determine the incidence of central venous device-related blood stream infection and thrombosis in patients treated with moderate dose continuous-infusion interleukin-2 (IL-2). METHODS:The records of 160 consecutive patients treated at the University of Wisconsin Hospital and Clin...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-02-15 00:00:00
abstract:BACKGROUND:Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22629
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:Colorectal cancer incidence rates vary widely internationally, by race and gender, and have changed over time. Investigation of the patterns by subsite within the colorectum may suggest clues of possible etiologic significance for further study. METHODS:Using population-based data on more than 120,000 cases...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3819::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract::Compliance in oncology clinic attendance was prospectively evaluated over a 12-month period at Harlem Hospital Center, an inner city municipal facility serving a predominantly black population. One hundred patients were followed (97 blacks, 2 Hispanics, 1 white) with an average age of 60 years. There were 41 men and 5...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860801)58:3<793::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract::Extracardiac rhabdomyomas are rare benign neoplasms that in the past have been divided by histologic criteria into adult and fetal types. In this series, 15 previously unpublished cases are presented and analyzed in combination with 51 acceptable cases from the literature. The adult type of rhabdomyoma occurs almost e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4<780::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify biologic differences between ovarian clear cell carcinoma and other ovarian adenocarcinomas by comparing the expression of cell cycle regulatory molecules and by analyzing the survival of the patients. METHODS:In 51 cases of epithelial ovarian carcinoma, the express...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990201)85:3<669::aid-cnc
更新日期:1999-02-01 00:00:00
abstract::This report is based on 903 patients with resections for gastric carcinoma between October 1957, and July 1969, entered in controlled trials of adjuvant therapy with Thio-TEPA and FUDR. Neither Thio-TEPA nor FUDR, as administered, prolonged survival. The extent of disease at the time of curative surgery is related to ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197709)40:3<1318::aid-cncr282040
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:To propose 'never-smoking nonsmall cell lung cancer (NSCLC)' as a separate entity, the clinicopathologic differences of operable NSCLC between never-smoking patients and patients with a history of smoking were investigated. METHODS:The medical records of 1405 patients with primary NSCLC who underwent a comp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23679
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long-term effects, especially on physical recovery, are unknown. METHODS:Longitudinal data from newly diagnosed breast cancer patients (N=100) who were married or cohabiting were used. Patients we...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.23964
更新日期:2009-01-01 00:00:00
abstract::Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fract...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850115)55:2<450::aid-cncr28205
更新日期:1985-01-15 00:00:00
abstract:METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1943::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Strumal carcinoids (SC) are ovarian tumors containing thyroid parenchyma admixed with carcinoid elements. Microscopically, the carcinoid component of SC usually presents a ribbon or trabecular pattern similar to the pattern exhibited by hindgut carcinoids. The authors designed an immunohistochemical study to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930901)72:5<1673::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract::After a series of studies on the linkage of reserpine with breast cancer, both evidence and interpretation appeared to be in conflict. Our case-control survey of long-term, comprehensive records from the Kaiser Foundation Medical Care Program, on 108 hypertensive breast cancer cases and 324 hypertensive controls, matc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<761::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::A case of bronchial mucoepidermoid carcinoma is reported, the presentation of which was as cutaneous metastases. Histologic, histochemical, and ultrastructural features of the neoplasm are described, and the literature pertaining to bronchial mucoepidermoid carcinoma is reviewed. This case illustrates the potential fo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861201)58:11<2556::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract::The ability of infantile hypercalcemic tumors (three rhabdoid renal tumors, one cellular mesoblastic nephroma, and one hepatoblastoma) to produce parathyroid hormone (PTH) was tested using RNA-DNA hybridization. Results were compared with those obtained in one lung epidermoid carcinoma and one parathyroid adenoma from...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880715)62:2<303::aid-cncr28206
更新日期:1988-07-15 00:00:00
abstract:BACKGROUND:The mortality rate associated with fever accompanied by pulmonary infiltrates after chemotherapy for hematologic malignancies remains higher than the corresponding rate associated with febrile neutropenia without pulmonary infiltrates. Nonetheless, few studies have focused on the factors that predict outcome...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20406
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:In view of the many studies of early stage colorectal carcinoma from Japan, it is essential to know whether the criteria for the histologic diagnosis of colorectal carcinoma are similar in Japan and Western countries. METHODS:Eight expert pathologists from Japan (4), North America (2), and Europe (2) indivi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980101)82:1<60::aid-cncr
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND METHODS:Predictors of distant relapse following conservative surgery for breast cancer were studied in a review of 425 women. Five steps of breast cancer patient management were defined in which increasing amounts of information, potentially relevant to prognosis for metastasis-free survival (MFS), were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930815)72:4<1261::aid-cncr2820
更新日期:1993-08-15 00:00:00
abstract:BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20098
更新日期:2004-03-15 00:00:00
abstract::The cytogenetic findings in 31 liposarcomas from 26 patients are reported. Four other tumors did not grow. Three histologic types are represented in this analysis. The well-differentiated liposarcomas were characterized by telomeric associations, large marker chromosomes and ring chromosomes, and in some cases, double...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920515)69:10<2484::aid-cncr282
更新日期:1992-05-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify genome-wide single nucleotide variants and mutations in African American patients with colorectal cancer (CRC). There is a need of such studies in African Americans, because they display a higher incidence of aggressive CRC tumors. METHODS:We performed whole exome s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28922
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Total body irradiation (TBI) is commonly used with autologous bone marrow transplantation (BMT) for treatment of hematologic malignancies. Pulmonary complications of TBI can cause long-term morbidity and mortality. The authors have compared the pulmonary toxicity and efficacy of two different TBI fractionati...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20011001)92:7<1949::aid-cncr1714
更新日期:2001-10-01 00:00:00
abstract::Cases of systemic lupus erythematosus, systemic sclerosis, periarteritis nodosa, and dermato- and polymyositis autopsied in Japan during a recent, 7-year period (1972-1978) were studied to assess the incidence of cancer as a complication. In comparison with the other three groups, cases of dermato- and polymyositis (D...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1841::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract::Serum sialyltransferases and fucosyltransferases measured by an affinity adsorbent technique were studied in 27 exactly defined patients with malignant pulmonary diseases. Fourteen patients with benign pulmonary diseases and 56 with benign surgical diseases were used as controls. Enzyme activities were expressed as am...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1679::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28196
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:The efficacy of the current 6th edition of the American Joint Committee on Cancer (AJCC) tumor staging criteria in improving outcome prediction for patients with oropharyngeal cancer was analyzed. METHODS:From the database of the Department of Radiation Oncology at the University of Texas M. D. Anderson Can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21867
更新日期:2006-05-01 00:00:00