The metabolic syndrome and risk of incident colorectal cancer.


BACKGROUND:The authors tested the hypothesis that the metabolic syndrome (> or =3 of the following components: high blood pressure, increased waist circumference, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, or diabetes/hyperglycemia) is a risk factor for colorectal cancer. METHODS:Data from the Atherosclerosis Risk in Communities (ARIC) multicenter prospective cohort study were used. Metabolic syndrome components and other risk factors were collected during 1987 to 1989 from the 14,109 men and women in these analyses. One hundred ninety-four incident colorectal cancers were identified through the Year 2000. Multivariate Cox proportional hazards regression analyses were used to examine associations. RESULTS:Baseline metabolic syndrome (> or =3 components vs. 0 components) had a positive association with age-adjusted and gender-adjusted colorectal cancer incidence (relative risk [RR], 1.49; 95% confidence interval [95%CI], 1.0-2.4); this association was attenuated after multivariate adjustment (RR, 1.39; 95%CI, 0.9-2.2). There was a dose-response association between colorectal cancer incidence and the number of metabolic syndrome components present at baseline (P for trend = .006) after multivariate adjustment. Analysis of gender revealed that the multivariate-adjusted association of metabolic syndrome with colorectal cancer was stronger in men (RR, 1.78; 95%CI, 1.0-3.6) and weaker in women (RR, 1.16; 95%CI, 0.6-2.2). CONCLUSIONS:In this population-based cohort, metabolic syndrome was a risk factor for incident colorectal cancer in men but not women. Evidence is growing that the metabolic syndrome may be a marker for a physiologic milieu of growth that encourages tumor initiation, promotion, and/or progression.






Ahmed RL,Schmitz KH,Anderson KE,Rosamond WD,Folsom AR




Has Abstract


2006-07-01 00:00:00














  • Analysis of factors related to the occurrence of chronic disseminated candidiasis in patients with acute leukemia in a non-bone marrow transplant setting: a follow-up study.

    abstract:BACKGROUND:Chronic disseminated candidiasis (CDC) is a serious complication of treatment in patients with acute leukemia. Although some general risk factors are known to predispose to systemic fungal infections, few studies have addressed the relevance of certain clinical and laboratory features in patients with CDC. ...


    pub_type: 杂志文章


    authors: Sallah S,Wan JY,Nguyen NP,Vos P,Sigounas G

    更新日期:2001-09-15 00:00:00

  • The role of chemotherapy for node-negative breast cancer.

    abstract::Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...


    pub_type: 杂志文章,评审


    authors: Cooper MR

    更新日期:1991-03-15 00:00:00

  • Postirradiation mixed müllerian tumors of the uterus: a comparative clinicopathologic study.

    abstract::Nine patients with mixed müllerian tumors (MMT) of the uterus associated with a history of prior pelvic irradiation were compared clinically and pathologically with 8 nonirradiation-associated MMT control patients. Patients with postirradiation tumors presented at a younger age and with symptoms indicative of extensiv...


    pub_type: 杂志文章


    authors: Varela-Duran J,Nochomovitz LE,Prem KA,Dehner LP

    更新日期:1980-04-01 00:00:00

  • A phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma.

    abstract:BACKGROUND:Previous biochemotherapy regimens for metastatic melanoma have required attenuated dosages of interleukin 2 (IL-2) that may have compromised efficacy. METHODS:In a phase 2 study, the authors tested sequential temozolomide (75 mg/m2 per day orally for 3 weeks) followed by high-dose, IL-2 (600,000 U/kg per do...


    pub_type: 杂志文章


    authors: Tarhini AA,Kirkwood JM,Gooding WE,Moschos S,Agarwala SS

    更新日期:2008-10-01 00:00:00

  • Self-examination and clinical examination of the breast.

    abstract::The techniques of self breast examination and the clinical examination of the breasts are described briefly. The potential value and the limitations of these tests in screening for breast cancer are reviewed. In a Cancer Society Monograph in 1958, Haagensen said, "It is probable that, from the point of view of the gre...


    pub_type: 杂志文章


    authors: Venet L

    更新日期:1980-08-15 00:00:00

  • Environmental factors in cancer of the larynx: a second look.

    abstract::During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably i...


    pub_type: 杂志文章


    authors: Wynder EL,Covey LS,Mabuchi K,Mushinski M

    更新日期:1976-10-01 00:00:00

  • Primary liver cancer incidence among American Indians and Alaska Natives, US, 1999-2004.

    abstract:BACKGROUND:American Indians and Alaska Natives (AI/AN) experience higher morbidity and mortality from primary liver cancer than other United States (US) populations, but racial misclassification in medical records results in underestimates of disease burden. METHODS:To reduce misclassification, National Program of Can...


    pub_type: 杂志文章


    authors: Jim MA,Perdue DG,Richardson LC,Espey DK,Redd JT,Martin HJ,Kwong SL,Kelly JJ,Henderson JA,Ahmed F

    更新日期:2008-09-01 00:00:00

  • Association of the -160 C --> a promoter polymorphism of E-cadherin gene with gastric carcinoma risk.

    abstract:BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...


    pub_type: 杂志文章


    authors: Wu MS,Huang SP,Chang YT,Lin MT,Shun CT,Chang MC,Wang HP,Chen CJ,Lin JT

    更新日期:2002-03-01 00:00:00

  • The seventies evolution in liver surgery for cancer.

    abstract::During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been i...


    pub_type: 杂志文章


    authors: Fortner JG,MacLean BJ,Kim DK,Howland WS,Turnbull AD,Goldiner P,Carlon G,Beattie EJ Jr

    更新日期:1981-05-01 00:00:00

  • Influence of private practice setting and physician characteristics on the use of breast cancer adjuvant chemotherapy for elderly women.

    abstract:BACKGROUND:Although >70% of younger women with nonmetastatic breast cancer (BC) received adjuvant chemotherapy, only approximately 15% to 20% of elderly women with BC received chemotherapy. The decision to treat may be associated with nonmedical factors, such as patient, physician, or practice characteristics. In the c...


    pub_type: 杂志文章


    authors: Hershman DL,Buono D,McBride RB,Tsai WY,Neugut AI

    更新日期:2009-09-01 00:00:00

  • Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats.

    abstract::Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...


    pub_type: 杂志文章,评审


    authors: Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

    更新日期:2018-12-15 00:00:00

  • Changes in chromosomal proteins in colon cancer: the complexity and DNA-binding properties of tumor-associated proteins and evidence for their association with the malignant state in human colonic epithelium.

    abstract::The properties of two classes of nonhistone nuclear proteins (NHNP) whose appearance has been correlated with the process of carcinogenesis in the colonic epithelium of rats given 1,2-dimethylhydrazine (DMH) have been investigated. NHNP isolated from adenocarcinomas of the colon were tested for their binding to homolo...


    pub_type: 杂志文章


    authors: Boffa LC,Allfrey VG

    更新日期:1977-11-01 00:00:00

  • Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease.

    abstract:BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive funct...


    pub_type: 杂志文章


    authors: Sherman AM,Jaeckle K,Meyers CA

    更新日期:2002-09-15 00:00:00

  • The single palpable thyroid nodule: evaluation by 99mTc-pertechnetate imaging.

    abstract::The role of 99mTc-pertechnetate thyroid imaging in the preoperative assessment of patients with single palpable thyroid nodules was evaluated. The frequency of cancer in hypofunctional nodules was similar to that found in previous studies with 131I. The 99mTc-pertechnetate image allowed a reliable separation of pathol...


    pub_type: 杂志文章


    authors: Alderson PO,Sumner HW,Siegel BA

    更新日期:1976-01-01 00:00:00

  • Brain metastasis from renal cell carcinoma: presentation, recurrence, and survival.

    abstract:BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...


    pub_type: 杂志文章


    authors: Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

    更新日期:2008-10-01 00:00:00

  • Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate.

    abstract:BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...


    pub_type: 临床试验,杂志文章


    authors: Wimalawansa SJ

    更新日期:1994-04-15 00:00:00

  • Development of a brief screening interview for adjustment disorders and major depression in patients with cancer.

    abstract:BACKGROUND:Adjustment disorders and major depression are common psychiatric disorders in patients with cancer and have a serious impact on quality of life. The problem in clinical oncology settings is underrecognition of these disorders; as a result, screening is recommended to detect them. The goal of the current stud...


    pub_type: 杂志文章


    authors: Akizuki N,Akechi T,Nakanishi T,Yoshikawa E,Okamura M,Nakano T,Murakami Y,Uchitomi Y

    更新日期:2003-05-15 00:00:00

  • Enrollment on clinical trials does not improve survival for children with acute myeloid leukemia: A population-based study.

    abstract:BACKGROUND:It is questionable whether enrollment on clinical trials offers any survival advantage at the population level over standard-of-care treatment. The objectives of this study were to describe the impact of trial enrollment on event-free survival and overall survival in pediatric acute myeloid leukemia (AML) us...


    pub_type: 杂志文章


    authors: Truong TH,Pole JD,Barber R,Dix D,Kulkarni KP,Martineau E,Randall A,Stammers D,Strahlendorf C,Strother D,Sung L

    更新日期:2018-10-15 00:00:00

  • Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis.

    abstract:BACKGROUND:Cirrhosis of viral etiology due to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for hepatocellular carcinoma (HCC). The current study evaluated the rate of incidence of HCC in patients with compensated cirrhosis of viral etiology. METHODS:Two hundred fifty-nine cirrhotic pat...


    pub_type: 杂志文章


    authors: Chiaramonte M,Stroffolini T,Vian A,Stazi MA,Floreani A,Lorenzoni U,Lobello S,Farinati F,Naccarato R

    更新日期:1999-05-15 00:00:00

  • Outcome of advanced, unresectable conventional central chondrosarcoma.

    abstract:BACKGROUND:For patients who have chondrosarcoma with unresectable disease, because of tumor location, tumor size, or extensive metastatic disease, treatment options are very limited because of their relative resistance to radiotherapy and chemotherapy. The overall survival of this patient population is poor; however, s...


    pub_type: 杂志文章,多中心研究


    authors: van Maldegem AM,Gelderblom H,Palmerini E,Dijkstra SD,Gambarotti M,Ruggieri P,Nout RA,van de Sande MA,Ferrari C,Ferrari S,Bovée JV,Picci P

    更新日期:2014-10-15 00:00:00

  • Findings from NSABP Protocol No. B-04: comparison of radical mastectomy with alternative treatments. II. The clinical and biologic significance of medial-central breast cancers.

    abstract::Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...


    pub_type: 杂志文章


    authors: Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

    更新日期:1981-10-15 00:00:00

  • Cytology of myoepithelial carcinoma of the salivary gland.

    abstract:BACKGROUND:Myoepithelial carcinoma, also know as malignant myoepithelioma, is rare in the salivary gland, and its cytologic features have rarely been reported. DESIGN:Four cases of myoepithelial carcinoma with cytology were retrieved from the archives of the Pathology Departments of two academic institutes. In three c...


    pub_type: 杂志文章


    authors: Chhieng DC,Paulino AF

    更新日期:2002-02-25 00:00:00

  • Diffuse pagetoid squamous cell carcinoma in situ of the esophagus: a case report.

    abstract:BACKGROUND:In Western countries, esophageal squamous cell carcinoma is usually advanced at presentation and is rarely diagnosed in situ. The authors studied an in situ squamous cell carcinoma that occupied the entire mucosa of a 9 cm length of esophagus, causing dysphagia for solid food in a woman aged 68 years. METHO...


    pub_type: 杂志文章


    authors: Chu P,Stagias J,West AB,Traube M

    更新日期:1997-05-15 00:00:00

  • Dysgerminoma of the ovary. An immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells.

    abstract:BACKGROUND:Human neoplasms often are accompanied by an inflammatory infiltrate. It has been proposed that this represents an immunologic response to the tumor. Dysgerminoma, a germ cell tumor of the ovary, is a classic example of this phenomenon. The authors investigated the immunophenotype of the tumor-infiltrating ly...


    pub_type: 杂志文章


    authors: Dietl J,Horny HP,Ruck P,Kaiserling E

    更新日期:1993-04-15 00:00:00

  • Oral bisphosphonates: A review of clinical use in patients with bone metastases.

    abstract:BACKGROUND:This study was conducted to review the efficacy and safety of oral bisphosphonates for the treatment of bone metastases in cancer patients. METHODS:Available published clinical studies of oral bisphosphonates in bone metastases from 1980 to the present were identified through a MEDLINE search and from liter...


    pub_type: 杂志文章,评审


    authors: Major PP,Lipton A,Berenson J,Hortobagyi G

    更新日期:2000-01-01 00:00:00

  • Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas.

    abstract:BACKGROUND:Soft tissue sarcomas of the head and neck represent uncommon malignant neoplasms. With the exception of orbital and parameningeal sites, the treatment of sarcomas in the head and neck has not been standardized. The authors used a prospectively collected database of adult soft tissue sarcomas to identify prog...


    pub_type: 杂志文章


    authors: Kraus DH,Dubner S,Harrison LB,Strong EW,Hajdu SI,Kher U,Begg C,Brennan MF

    更新日期:1994-07-15 00:00:00

  • Long-term results of a prospective study on the treatment of medulloblastoma in adults.

    abstract:BACKGROUND:Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow-up has tended to be short. Furthermore, the different therapeutic strategies used in these patients has made it difficult to assess survival rates and prognostic factors. METHODS:In 1989...


    pub_type: 杂志文章


    authors: Brandes AA,Franceschi E,Tosoni A,Blatt V,Ermani M

    更新日期:2007-11-01 00:00:00

  • Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis.

    abstract:BACKGROUND:Stomatitis has been found to be a major dose-limiting toxicity from bolus 5-fluorouracil-based (5-FU) chemotherapy regimens, despite the use of oral cryotherapy. Pursuant to preliminary data which suggested that a chamomile mouthwash might ameliorate this toxicity, a prospective trial was developed to test c...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fidler P,Loprinzi CL,O'Fallon JR,Leitch JM,Lee JK,Hayes DL,Novotny P,Clemens-Schutjer D,Bartel J,Michalak JC

    更新日期:1996-02-01 00:00:00

  • The use and effectiveness of rituximab maintenance in patients with follicular lymphoma diagnosed between 2004 and 2007 in the United States.

    abstract:BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...


    pub_type: 杂志文章,多中心研究


    authors: Nastoupil LJ,Sinha R,Byrtek M,Zhou X,Taylor MD,Friedberg JW,Link BK,Cerhan JR,Dawson K,Flowers CR

    更新日期:2014-06-15 00:00:00

  • Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure.

    abstract::Between March 1973, and December 1976, 22 patients who developed disease progression during or after MOPP therapy were treated with a new combination, B-CAVe (Bleomycin 5 mg/m2 iv days 1, 28, 35; CCNU 100 mg/m2 po day 1; adriamycin 60 mg/m2 iv day 1; and vinblastine 5 mg/m2 iv day 1). Objective responses were achieved...


    pub_type: 杂志文章


    authors: Porzig KJ,Portlock CS,Robertson A,Rosenberg SA

    更新日期:1978-05-01 00:00:00