Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.

abstract：BACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC). METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospective...

journal_title：Cancer

authors： Brennan SM,Gregory DL,Stillie A,Herschtal A,Mac Manus M,Ball DL

更新日期：2010-02-15 00:00:00

abstract：:The aims of this study were as follows: to confirm that the presence of estrogen (ER) and progesterone (PgR) receptors is an indicator of clinical behavior of human breast cancer independent of other known prognostic factors; to seek clinical correlates of those receptor values that best predict the overall disease ev...

journal_title：Cancer

authors： Vollenweider-Zerargui L,Barrelet L,Wong Y,Lemarchand-Béraud T,Gómez F

更新日期：1986-03-15 00:00:00

abstract：BACKGROUND:Optimal chemotherapy for treating mixed-phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World H...

journal_title：Cancer

authors： Orgel E,Alexander TB,Wood BL,Kahwash SB,Devidas M,Dai Y,Alonzo TA,Mullighan CG,Inaba H,Hunger SP,Raetz EA,Gamis AS,Rabin KR,Carroll AJ 3rd,Heerema NA,Berman JN,Woods WG,Loh ML,Zweidler-McKay PA,Horan JT,Children's

更新日期：2020-02-01 00:00:00

abstract：:Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...

journal_title：Cancer

authors： Wagner HN Jr,Conti PS

更新日期：1991-02-15 00:00:00

abstract：:A series of 273 unselected patients with bronchial carcinoma, comprising a total prospective 5-year study from a Swedish county with an observed 5-year survival of 7.0%, is presented. The autopsy rate in deceased patients was 94%. All diagnoses were histologically or cytologically verified. The 5-year survival rates f...

journal_title：Cancer

authors： Nõu E

更新日期：1984-05-15 00:00:00

abstract：BACKGROUND:Optimal treatment of human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma (NHL) has yet to be defined, because chemotherapy could exacerbate immunodeficiency, with subsequent adverse effects for patients. METHODS:The authors investigated the feasibility of an intensive chemotherapy regimen for...

journal_title：Cancer

authors： Costello RT,Zerazhi H,Charbonnier A,de Colella JM,Alzieu C,Poizot-Martin I,Cohen R,Bardou VJ,Xerri L,Olive D,Nezri M,Lepeu G,Gastaut JA

更新日期：2004-02-15 00:00:00

abstract：:Plasma CEA concentration before and after administration of secretin and cholecystokinin-pancreozymin has been determined in 89 patients with neoplastic or inflammatory pancreatric disease and other neoplastic and nonneoplastic disorders. The purpose of the study was to expore the specificity and sensitivity of such a...

journal_title：Cancer

authors： Lindstedt G,Lundberg PA,Rolny P

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...

journal_title：Cancer

authors： Rauh-Hain JA,Clemmer JT,Bradford LS,Clark RM,Growdon WB,Goodman A,Boruta DM 2nd,Schorge JO,del Carmen MG

更新日期：2013-10-15 00:00:00

abstract：:Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...

journal_title：Cancer

authors： Parfrey NA,Mann RB,Selonick SE,Beschorner WE

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:A proposed pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen (PSA) era. The impact of margin status on the survival outcome of patients with otherwise organ-confined disease (i.e., without extraprostatic extension o...

journal_title：Cancer

authors： Blute ML,Bostwick DG,Seay TM,Martin SK,Slezak JM,Bergstralh EJ,Zincke H

更新日期：1998-03-01 00:00:00

abstract：:A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...

journal_title：Cancer

authors： Nagendran T,Patel MN,Gaillard WE,Imm F,Walker M

更新日期：1980-02-15 00:00:00

abstract：:The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...

journal_title：Cancer

authors： Stock RJ,Fu YS,Carter JR

更新日期：1979-09-01 00:00:00

abstract：:A case of a patient with a metastatic ACTH (adrenocorticotrophic hormone)-producing gastric carcinoid APUD (amine precursor uptake and decarboxylation) tumor is presented. The patient presented with Cushing's syndrome and very high levels of ACTH. The Cushing's syndrome was controlled medically, and when the patient d...

journal_title：Cancer

authors： Marcus FS,Friedman MA,Callen PW,Churg A,Harbour J

更新日期：1980-09-01 00:00:00

abstract：:Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically eva...

journal_title：Cancer

authors： Green LK

更新日期：1990-04-01 00:00:00

abstract：:The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...

journal_title：Cancer

authors： Sharma S,Mishra MC,Kapur BM,Verma K,Nath I

更新日期：1991-12-15 00:00:00

abstract：BACKGROUND:Hormone replacement therapy (HRT) has proven and presumable benefits for women desiring postmenopausal health preservation. Among HRT-associated risks, the fear of breast carcinoma intimidates women and physicians contemplating hormonal treatment and limits long-term compliance. Identifying effective alterna...

journal_title：Cancer

authors： Diamanti-Kandarakis E,Sykiotis GP,Papavassiliou AG

更新日期：2003-01-01 00:00:00

abstract：:A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...

journal_title：Cancer

authors： Sarrazin D,Lê M,Rouëssé J,Contesso G,Petit JY,Lacour J,Viguier J,Hill C

更新日期：1984-03-01 00:00:00

abstract：:It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...

journal_title：Cancer

authors： Bajardi F

更新日期：1984-08-15 00:00:00

abstract：:Twelve cases of ovarian adenocarcinoma were studied for alterations in proto-oncogenes, and a unique pattern of altered ras proto-oncogenes was observed. Amplification of ras-Ki was found in three of seven ovarian tumors and amplification of ras-Ha in one of 12. In contrast, ras-Ha amplification was not found in any o...

journal_title：Cancer

authors： Zhou DJ,Gonzalez-Cadavid N,Ahuja H,Battifora H,Moore GE,Cline MJ

更新日期：1988-10-15 00:00:00

abstract：:The authors describe two cases of epithelioid sarcoma of the vulva and summarize the clinical and pathologic experience with this vulvar neoplasm. Findings indicate that epithelioid sarcoma of the vulva usually occurs in the labia majora of young women, but may occur in later life. Clinically it may mimic a Bartholin'...

journal_title：Cancer

authors： Ulbright TM,Brokaw SA,Stehman FB,Roth LM

更新日期：1983-10-15 00:00:00

abstract：:Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...

journal_title：Cancer

authors： Lightdale CJ

更新日期：1982-12-01 00:00:00

abstract：:A retrospective study is reported of 120 consecutive cases of patients presenting with brain metastases as the primary sign of their malignancy. Primary site was found in 62 patients (53 while alive and 9 at postmortem examination) and remained unknown in 58. Lung was the most frequent primary site (45% of known sites...

journal_title：Cancer

authors： Le Chevalier T,Smith FP,Caille P,Constans JP,Rouesse JG

更新日期：1985-08-15 00:00:00

abstract：:Compliance in oncology clinic attendance was prospectively evaluated over a 12-month period at Harlem Hospital Center, an inner city municipal facility serving a predominantly black population. One hundred patients were followed (97 blacks, 2 Hispanics, 1 white) with an average age of 60 years. There were 41 men and 5...

journal_title：Cancer

authors： Garrett TJ,Ashford A,Savage DG

更新日期：1986-08-01 00:00:00

abstract：:The incidence of long thoracic nerve palsy after radical mastectomy has been documented to be approximately 10%. No cases have been reported after the more recent treatment for breast cancer, lumpectomy with axillary dissection. This more recent surgical procedure is customarily followed by aggressive radiation therap...

journal_title：Cancer

authors： Pugliese GN,Green RF,Antonacci A

更新日期：1987-09-15 00:00:00

abstract：BACKGROUND:The majority of patients with breast carcinoma with > or = 10 metastatic axillary lymph nodes (ALNs) develop recurrent disease within 5 years from diagnosis. The purpose of the current study, performed retrospectively, was to characterize the natural history of this subset of patients, both before and after ...

journal_title：Cancer

authors： Montero AJ,Rouzier R,Lluch A,Theriault RL,Buzdar AU,Delaloge S,Bermejo B,Le M,Kau SW,Dunant A,Arriagada R,Spielmann M,Garcia-Conde J,Sahin AA,Singletary SE,Hortobagyi GN,Valero V

更新日期：2005-07-15 00:00:00

abstract：:Activity of Poly (C) avid ribonuclease was estimated in sera of 129 patients with different malignancies. All patients had histologically verified carcinomas, normal renal function, and no signs of acute catabolic condition. Activity values were compared with those of normal subjects (U-test, Mann and Whitney) separat...

journal_title：Cancer

authors： Francesconi M,Meryn S,Rogan AM,Szalay S,Graninger W,Schmidbauer CP

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS:For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers...

journal_title：Cancer

authors： Nakanishi Y,Ochiai A,Yoshimura K,Kato H,Shimoda T,Yamaguchi H,Tachimori Y,Watanabe H,Hirohashi S

更新日期：1998-04-15 00:00:00

abstract：BACKGROUND:Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti-neuroectodermal antibodies in the absence of PND. Whether...

journal_title：Cancer

authors： Vural B,Chen LC,Saip P,Chen YT,Ustuner Z,Gonen M,Simpson AJ,Old LJ,Ozbek U,Gure AO

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:The American Cancer Society has sponsored community-based, low-cost, Breast Cancer Detection Awareness Projects throughout the United States. The authors hypothesized that these projects tend to exclude minorities and women of lower socioeconomic status--groups with a higher incidence of late-stage disease. ...

journal_title：Cancer

authors： Roetzheim RG,Vandurme DJ,Brownlee HJ,Herold AH,Pamies RJ,Woodard L,Blair C

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Forty-eight patients with resected Stages IIA and IIB melanoma were immunized with two tumor antigen epitope peptides derived from gp100(209-217) (210M) (IMDQVPSFV) and tyrosinase(368-376) (370D) (YMDGTMSQV) emulsified with incomplete Freund's adjuvant (IFA). Patients were assigned randomly to receive either...

journal_title：Cancer

authors： Weber J,Sondak VK,Scotland R,Phillip R,Wang F,Rubio V,Stuge TB,Groshen SG,Gee C,Jeffery GG,Sian S,Lee PP

更新日期：2003-01-01 00:00:00