Abstract:
BACKGROUND:Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS:For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS:Ninety-two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6-10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas (P < 0.01). CONCLUSIONS:Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract.
journal_name
Cancerjournal_title
Cancerauthors
Nakanishi Y,Ochiai A,Yoshimura K,Kato H,Shimoda T,Yamaguchi H,Tachimori Y,Watanabe H,Hirohashi Ssubject
Has Abstractpub_date
1998-04-15 00:00:00pages
1454-9issue
8eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19980415)82:8<1454::AID-CNjournal_volume
82pub_type
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