Abstract:
:The DNA content of human plasma cells from myeloma patients relative to that of leukocytes was determined by flow and microscopic cytofluorometry after propidium iodide and fluorescent Feulgen staining, respectively. Mononucleated myeloma plasma cells from all of the 17 patients studied contained more DNA (17 to 58%) than the leukocytes from the patient. The binucleated and trinucleated plasma cells, which were more prevalent in advanced cases, contained up to two and three times, respectively, the amount of DNA determined in the mononucleated plasma cells. These observations suggest that the ploidy abnormalities of myeloma plasma cells are even more extensive than the numerous karyotypic studies have indicated.
journal_name
Cancerjournal_title
Cancerauthors
Brox L,Mowles D,Pollock B,Belch Adoi
10.1002/1097-0142(19810515)47:10<2433::aid-cncr282subject
Has Abstractpub_date
1981-05-15 00:00:00pages
2433-6issue
10eissn
0008-543Xissn
1097-0142journal_volume
47pub_type
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