Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.


BACKGROUND:A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS:Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic cycle ergometry sessions per week at 60% to 100% of peak workload for 14 weeks. Peak oxygen consumption (VO(2peak)) was assessed using an incremental exercise test. QOL and fatigue were assessed using the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale. RESULTS:Nineteen patients completed the study. Intention-to-treat analysis indicated that VO(2peak) increased 1.1 mL/kg(-1)/min(-1) (95% confidence interval [CI], -0.3-2.5; P = .109) and peak workload increased 9 W (95% CI, 3-14; P = .003), whereas FACT-L increased 10 points (95% CI, -1-22; P = .071) and fatigue decreased 7 points (95% CI; -1 to -17; P = .029) from baseline to postintervention. Per protocol analyses indicated greater improvements in cardiopulmonary and QOL endpoints among patients not receiving adjuvant chemotherapy. CONCLUSIONS:This pilot study provided proof of principle that supervised aerobic training is safe and feasible for postsurgical NSCLC patients. Aerobic exercise training is also associated with significant improvements in QOL and select cardiopulmonary endpoints, particularly among patients not receiving chemotherapy. Larger randomized trials are warranted.






Jones LW,Eves ND,Peterson BL,Garst J,Crawford J,West MJ,Mabe S,Harpole D,Kraus WE,Douglas PS




Has Abstract


2008-12-15 00:00:00














  • Occurrence of anti-retinal ganglion cell antibodies in patients with small cell carcinoma of the lung.

    abstract::This report describes a patient with small-cell carcinoma of the lung associated with blindness. The serum of this patient was tested for immunoreactivity with retinal sections because there was no evidence of tumor metastasis to the central nervous system and because neuroendocrine cells of the lung share common anti...


    pub_type: 杂志文章


    authors: Kornguth SE,Klein R,Appen R,Choate J

    更新日期:1982-10-01 00:00:00

  • Differential alpha-fetoprotein lectin binding in hepatocellular carcinoma. Diagnostic utility at low serum levels.

    abstract::The reactivity of serum alpha-fetoprotein (AFP) from 20 patients with hepatocellular carcinoma (HCC) with immobilized lentil lectin was examined and found to be significantly greater (39% +/- 18%) than that of the same protein from seven patients with chronic liver disease (CLD, 11.2% +/- 3.3%), seven with fulminant h...


    pub_type: 杂志文章


    authors: Du MQ,Hutchinson WL,Johnson PJ,Williams R

    更新日期:1991-01-15 00:00:00

  • Prognosis in adult acute myelogenous leukemia related to performance status and other factors.

    abstract::Pretreatment factors of prognostic value were sought in 54 consecutively treated cases of adult acute myelogenous leukemia. Twenty of 37 patients with a good (greater than 50%) pretreatment Karnofsky performance status (P.S.) achieved complete remission (C.R.), while only 1/17 with a poor P.S. achieved C.R. This diffe...


    pub_type: 杂志文章


    authors: Kansal V,Omura GA,Soong SJ

    更新日期:1976-07-01 00:00:00

  • The Department of Veterans Affairs' unique clinical cancer research effort.

    abstract::Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatmen...


    pub_type: 杂志文章,评审


    authors: Hrushesky WJ

    更新日期:1994-11-01 00:00:00

  • Obesity and screening for breast, cervical, and colorectal cancer in women: a review.

    abstract::The literature examining obesity as a barrier to screening for breast, cervical, and colorectal cancer has not been evaluated systematically. With the increasing prevalence of obesity and its impact on cancer incidence and mortality, it is important to determine whether obesity is a barrier to screening so that cancer...


    pub_type: 杂志文章,评审


    authors: Cohen SS,Palmieri RT,Nyante SJ,Koralek DO,Kim S,Bradshaw P,Olshan AF

    更新日期:2008-05-01 00:00:00

  • Giant cell tumors of synovium (Pigmented villonodular synovitis) involving the vertebral column.

    abstract::Giant cell tumors of synovium (pigmented villonodular synovitis) involving the vertebral column recently have been seen in two women: the third and fourth cases to be reported in the English-language literature. Unlike the previously reported cases, both these tumors grew outside the dura and produced symptoms of spin...


    pub_type: 杂志文章


    authors: Weidner N,Challa VR,Bonsib SM,Davis CH Jr,Carrol TJ Jr

    更新日期:1986-05-15 00:00:00

  • Causes of death in long-term survivors of head and neck cancer.

    abstract:BACKGROUND:Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. METHODS:We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and ...


    pub_type: 杂志文章


    authors: Baxi SS,Pinheiro LC,Patil SM,Pfister DG,Oeffinger KC,Elkin EB

    更新日期:2014-05-15 00:00:00

  • Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma.

    abstract:BACKGROUND:The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC). METHODS:ZNF217 expression and amplification in OCCC was assessed by immunohistochemistry, fluorescence in situ hyb...


    pub_type: 杂志文章


    authors: Rahman MT,Nakayama K,Rahman M,Nakayama N,Ishikawa M,Katagiri A,Iida K,Nakayama S,Otsuki Y,Shih IeM,Miyazaki K

    更新日期:2012-06-01 00:00:00

  • Dose escalation of gemcitabine concomitant with radiation and cisplatin for nonsmall cell lung cancer: a phase 1-2 study.

    abstract:BACKGROUND:The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS:Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 ...


    pub_type: 杂志文章


    authors: Momm F,Kaden M,Tannock I,Schumacher M,Hasse J,Henke M

    更新日期:2010-10-15 00:00:00

  • The prevalence of patients with colorectal carcinoma under care in the U.S.

    abstract:BACKGROUND:Prevalence usually is defined as the proportion of individuals alive who previously had a diagnosis of the disease, regardless of whether the individuals still are receiving treatment or are cured. The objective of this study was to estimate the proportion of elderly patients with colorectal carcinoma (CRC) ...


    pub_type: 杂志文章


    authors: Mariotto A,Warren JL,Knopf KB,Feuer EJ

    更新日期:2003-09-15 00:00:00

  • Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options.

    abstract::Effective management of hepatic metastases from ocular and cutaneous melanoma remains a major therapeutic challenge. Treatment options include hepatic resection, hepatic intra-arterial (HIA) chemotherapy, chemoembolization, and hepatic perfusions. Evaluating the efficacy of these interventions is limited by the retros...


    pub_type: 杂志文章,评审


    authors: Agarwala SS,Eggermont AM,O'Day S,Zager JS

    更新日期:2014-03-15 00:00:00

  • Toxicity of very high dose nitrosourea administration.

    abstract::We report a case of inadvertent administration of over twice the usual dose of methyl-CCNU. The patient exhibited an early onset of bone marrow suppression. Profound pancytopenia, including lymphopenia, persisted for over seven weeks, Although early recovery started at about five weeks. Permanent marrow damage was ind...


    pub_type: 杂志文章


    authors: Breeden JH,Vollmer JT,Twomey PL

    更新日期:1982-11-01 00:00:00

  • Preoperative irradiation in carcinoma of the pancreas.

    abstract::Seventeen patients with carcinoma confined to the pancreas and the peripancreatic area received preoperative radiation therapy in an attempt to increase the resectability rate and to reduce the incidence of recurrence. The tumors were considered either unresectable or of borderline resectability. The radiation dose ra...


    pub_type: 杂志文章


    authors: Pilepich MV,Miller HH

    更新日期:1980-11-01 00:00:00

  • Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model.

    abstract:BACKGROUND:The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic fibroblast growth factor (bFGF) saporin (SAP) and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian teratocarcinoma PA-1 was examined in athymic nude mice. Alternative administration schedules to...


    pub_type: 杂志文章


    authors: Davol P,Beitz JG,Mohler M,Ying W,Cook J,Lappi DA,Frackelton AR Jr

    更新日期:1995-07-01 00:00:00

  • Response rate and local recurrence after concurrent immune checkpoint therapy and radiotherapy for non-small cell lung cancer and melanoma brain metastases.

    abstract:BACKGROUND:Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. METHODS:A total of 199 patients with melanoma and non-small cell ...


    pub_type: 杂志文章


    authors: Qian JM,Martin AM,Martin K,Hammoudeh L,Catalano PJ,Hodi FS,Cagney DN,Haas-Kogan DA,Schoenfeld JD,Aizer AA

    更新日期:2020-12-15 00:00:00

  • Effect of chemotherapeutic agents on metabolic and bactericidal activity of polymorphonuclear leukocytes.

    abstract::Blood was obtained on 36 occasions from 12 healthy adult volunteers and the polymorphonuclear leukocytes (PMNL) were separated. PMNL hexose monophosphate shunt activity of whole blood and ability of separated cells to phagocytize and kill E. coli were evaluated when the PMNL were incubated with normal pooled sera and ...


    pub_type: 杂志文章


    authors: Pickering LK,Ericsson CD,Kohl S

    更新日期:1978-10-01 00:00:00

  • Precursor lesions of Wilms' tumor in Indian children: a multiinstitutional study.

    abstract:BACKGROUND:Studies regarding different ethnic populations of children with Wilms' tumor (WT) in the U. S. have shown differences between age and gender incidence and the type of its precursor lesions (nephrogenic rests). To the authors' knowledge there are few reports in the literature regarding nephrogenic rests in a ...


    pub_type: 杂志文章,多中心研究


    authors: Mishra K,Mathur M,Logani KB,Kakkar N,Krishna A

    更新日期:1998-11-15 00:00:00

  • The role of the surgeon in whether patients with lymph node-positive colon cancer see a medical oncologist.

    abstract:BACKGROUND:Chemotherapy improves survival for patients with stage III colon cancer, but some older patients with lymph node-positive colon cancer do not see a medical oncologist and, thus, do not receive adjuvant chemotherapy. METHODS:To evaluate the role of the surgeon in determining referrals to medical oncology amo...


    pub_type: 杂志文章


    authors: Luo R,Giordano SH,Zhang DD,Freeman J,Goodwin JS

    更新日期:2007-03-01 00:00:00

  • Brain metastases from esophageal carcinoma: natural history, prognostic factors, and outcome.

    abstract:BACKGROUND:Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. METHODS:The records of 36 patients with brain metastases from esophageal carcinoma who were treated between 1986 a...


    pub_type: 杂志文章


    authors: Ogawa K,Toita T,Sueyama H,Fuwa N,Kakinohana Y,Kamata M,Adachi G,Saito A,Yoshii Y,Murayama S

    更新日期:2002-02-01 00:00:00

  • A prospective evaluation of the durability of palliative interventions for patients with metastatic breast cancer.

    abstract:BACKGROUND:Although systemic therapy for metastatic breast cancer (MBC) continues to evolve, there are scant data to guide physicians and patients when symptoms develop. In this article, the authors report the frequency and durability of palliative procedures performed in the setting of MBC. METHODS:From July 2002 to ...


    pub_type: 杂志文章


    authors: Morrogh M,Miner TJ,Park A,Jenckes A,Gonen M,Seidman A,Morrow M,Jaques DP,King TA

    更新日期:2010-07-15 00:00:00

  • Metastasizing basal cell carcinoma of the skin with myelophthisic anemia.

    abstract::A case report of a metastasizing basal cell carcinoma is presented, primary in the leg with regional inguinal lymph node metastasis, followed by extensive metastasis to skin and bone marrow with myelophthisic anemia and terminal splenohepatic and unilateral adrenal metastasis. ...


    pub_type: 杂志文章


    authors: Coletta DF,Haentze FE,Thomas CC

    更新日期:1968-10-01 00:00:00

  • Phase II evaluation of topotecan for pediatric central nervous system tumors.

    abstract:BACKGROUND:Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-hour infusion. The maximum t...


    pub_type: 临床试验,杂志文章


    authors: Blaney SM,Phillips PC,Packer RJ,Heideman RL,Berg SL,Adamson PC,Allen JC,Sallan SE,Jakacki RI,Lange BJ,Reaman GH,Horowitz ME,Poplack DG,Balis FM

    更新日期:1996-08-01 00:00:00

  • Partial splenic embolization for cancer patients with thrombocytopenia requiring systemic chemotherapy.

    abstract:BACKGROUND:Partial splenic embolization (PSE) has been used to improve hematologic parameters related to hypersplenism. The purpose of this study was to review our institutional experience with PSE for cancer patients with thrombocytopenia because of splenic sequestration precluding the administration of systemic thera...


    pub_type: 杂志文章


    authors: Kauffman CR,Mahvash A,Kopetz S,Wolff RA,Ensor J,Wallace MJ

    更新日期:2008-05-15 00:00:00

  • C-erbB-2 oncogene protein in in situ and invasive lobular breast neoplasia.

    abstract::Lobular carcinoma in situ (LCIS) has uncertain malignant potential; biologic markers that will identify patients at risk for a poor clinical outcome have been sought actively. Amplification of the c-erbB-2 protooncogene has been correlated with poor prognosis in invasive mammary carcinoma, and immunohistochemical eval...


    pub_type: 杂志文章


    authors: Porter PL,Garcia R,Moe R,Corwin DJ,Gown AM

    更新日期:1991-07-15 00:00:00

  • Donor-derived small cell lung carcinoma in a kidney transplant recipient.

    abstract:BACKGROUND:Transplantation of donor-derived malignancies during organ transplantation fortunately is very rare. Discontinuation of immunosuppressive medications under these circumstances has previously resulted in complete tumor rejection. Ectopic adrenocorticotropic hormone (ACTH) production may result in Cushing synd...


    pub_type: 杂志文章


    authors: Bodvarsson S,Burlingham W,Kusaka S,Hafez GR,Becker BN,Pintar T,Sollinger HW,Albertini MR

    更新日期:2001-11-01 00:00:00

  • A retrospective analysis of 10-year survivors from carcinoma of the lung.

    abstract::From 1949 to 1972, 4732 patients with carcinomas of the lung were seen. Of these, 118 patients were found alive at 10 years from their initial diagnosis and treatment. This number represents only 2.5% of all lung cancers seen because many have been lost to follow-up within the first ten years, and their true status is...


    pub_type: 杂志文章


    authors: Temeck BK,Flehinger BJ,Martini N

    更新日期:1984-03-15 00:00:00

  • Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor.

    abstract::Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA di...


    pub_type: 杂志文章


    authors: Olszewski W,Darzynkiewicz Z,Rosen PP,Schwartz MK,Melamed MR

    更新日期:1981-08-15 00:00:00

  • Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection.

    abstract:BACKGROUND:In Japan, where liver transplantation has not been used to treat patients with hepatocellular carcinoma (HCC), percutaneous ethanol injection (PEI) has been employed for those with small HCCs that are not amenable to surgical resection. In the current study, the authors evaluated PEI as a treatment for HCC p...


    pub_type: 杂志文章


    authors: Hasegawa S,Yamasaki N,Hiwaki T,Sako K,Komorizono Y,Baba Y,Imamura Y,Kubozono O,Yoshida A,Arima T

    更新日期:1999-11-01 00:00:00

  • Eosinophilic granular ceels in oligodendrogliomas. An ultrastructural study.

    abstract::In three cases of oligodendrogliomas, atypical cells rich in eosinophilic cytoplasm, resembling plump astroyctic or astroblastic cells, were studied under the electron microscopy. These cells showed finely granular cytoplasm with routine hematoxylin-eosin preparation; ultrastructurally, they exhibited abundant, round ...


    pub_type: 杂志文章


    authors: Takei Y,Mirra SS,Miles ML

    更新日期:1976-11-01 00:00:00

  • Does transurethral resection of a clinically benign prostate gland increase the risk of developing clinical prostate cancer? A 10-year follow-up study.

    abstract:BACKGROUND:Theoretical considerations have raised the suspicion that transurethral resection of the prostate (TURP) may increase the risk of developing prostate cancer in clinically benign prostate glands. Previous studies have not shown an increased risk among men who had undergone TURP for benign prostatic hyperplasi...


    pub_type: 杂志文章


    authors: Hammarsten J,Andersson S,Holmén A,Högstedt B,Peeker R

    更新日期:1994-10-15 00:00:00