Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

abstract：BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

journal_title：Cancer

authors： Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the a...

journal_title：Cancer

authors： Lara-Medina F,Pérez-Sánchez V,Saavedra-Pérez D,Blake-Cerda M,Arce C,Motola-Kuba D,Villarreal-Garza C,González-Angulo AM,Bargalló E,Aguilar JL,Mohar A,Arrieta Ó

更新日期：2011-08-15 00:00:00

abstract：:Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...

journal_title：Cancer

authors： Sherman DM,Neptune W,Weichselbaum R,Order SE,Piro AJ

更新日期：1978-05-01 00:00:00

abstract：:The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

journal_title：Cancer

authors： Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:Trimetrexate is an antifol that differs from methotrexate in ways that may be clinically important. Because methotrexate has activity in advanced bladder cancer, this trial was initiated. METHODS:Ambulatory patients with advanced urothelial carcinoma were treated with the nonclassic antifol trimetrexate at ...

journal_title：Cancer

authors： Witte RS,Elson P,Khandakar J,Trump DL

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:The purpose of the current study was to determine the prevalence of low bone mineral density (BMD) (ie, osteopenia) and identify factors associated with low BMD in young adult survivors of childhood acute lymphoblastic leukemia (ALL). METHODS:Dual energy x-ray absorptiometry was used to evaluate BMD in 74 r...

journal_title：Cancer

authors： Thomas IH,Donohue JE,Ness KK,Dengel DR,Baker KS,Gurney JG

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival. METHODS:Four hundred fifty-two women age < or = 35 years with breast carci...

journal_title：Cancer

authors： Gonzalez-Angulo AM,Broglio K,Kau SW,Eralp Y,Erlichman J,Valero V,Theriault R,Booser D,Buzdar AU,Hortobagyi GN,Arun B

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:The current study evaluated whether the risk of developing thyroid cancer in Asian women was associated with infertility and the use of fertility drugs. METHODS:The authors conducted a large, retrospective cohort study using Taiwan's National Health Insurance Research Database. From the insurance claims dat...

journal_title：Cancer

authors： Ding DC,Chen W,Wang JH,Lin SZ,Sung FC

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patient...

journal_title：Cancer

authors： Chamberlain MC

更新日期：1994-03-15 00:00:00

abstract：:Demonstration of malignant cells in blood specimens collected during transurethral resection of the prostate (TURP) has implicated TURP in the dissemination of prostatic cancer. Of 153 patients who underwent radiation therapy for prostate cancer between January 1977 and June 1990 and were retrospectively analyzed, 93 ...

journal_title：Cancer

authors： Pansadoro V,Sternberg CN,DePaula F,Florio A,Giannarelli D,Arcangeli G

更新日期：1991-11-01 00:00:00

abstract：:Forty-four cases of skin and soft tissue angiosarcoma seen at M. D. Anderson Hospital before 1976 were reviewed. The cases fell into six different clinical groups: scalp-face, 17 cases; postmastectomy, 14 cases; postradiation, 5 cases; leg with vascular stasis, 2 cases; breast, 2 cases; and miscellaneous, 4 cases. In ...

journal_title：Cancer

authors： Maddox JC,Evans HL

更新日期：1981-10-15 00:00:00

abstract：BACKGROUND:The treatment of patients with hepatocellular carcinoma (HCC) presents a major challenge, because associated cirrhosis limits the choice of chemotherapeutic agents. However, the abundant vascularity of HCC presents an attractive target for antiangiogenic therapy that potentially may be tolerated by cirrhotic...

journal_title：Cancer

authors： Patt YZ,Hassan MM,Lozano RD,Nooka AK,Schnirer II,Zeldis JB,Abbruzzese JL,Brown TD

更新日期：2005-02-15 00:00:00

abstract：:A distinctive glycopeptide, which acts as an acceptor for a cancer-associated galactosyltransferase, has been detected in sera and effusions of patients with extensive carcinoma. Cancer-associated galactosyltransferase acceptor (CAGA) purified from human malignant effusions was tested for its effects on cell growth in...

journal_title：Cancer

authors： Podolsky DK,Isselbacher KJ

更新日期：1980-03-15 00:00:00

abstract：:Lymphoid cells from two patients with hand-mirror variant of acute lymphoblastic leukemia (ALL) were studied with various monoclonal antibodies in attempts to determine their derivation and differentiation. The predominant feature of the malignant bone marrow cells was strong reactivity with antibody 3A1, which stains...

journal_title：Cancer

authors： Gramatzki M,Strong DM,Duval-Arnould B,Morstyn G,Schumacher HR

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population-based study of Detroit area men with localized PC to determine the outcome of bowel, urinary, and sexual ...

journal_title：Cancer

authors： Schwartz K,Bunner S,Bearer R,Severson RK

更新日期：2002-07-01 00:00:00

abstract：:Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...

journal_title：Cancer

authors： McDermott DF

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:To determine whether high-risk patients with hematuria receive evaluation according to guideline recommendations. METHODS:We recently performed a screening study for bladder cancer using a urine-based tumor marker in 1502 subjects at high risk based on aged > or = 50 years, > or = 10-year smoking history, a...

journal_title：Cancer

authors： Elias K,Svatek RS,Gupta S,Ho R,Lotan Y

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:The authors tested a biotherapy regimen involving recombinant interferon-alpha-2a (rIFN-alpha-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. METHODS:...

journal_title：Cancer

authors： Eton O,Buzaid AC,Bedikian AY,Smith TM,Papadopoulos NE,Ellerhorst JA,Hibberts JL,Legha SS,Benjamin RS

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...

journal_title：Cancer

authors： Salaun PY,Bodet-Milin C,Frampas E,Oudoux A,Saï-Maurel C,Faivre-Chauvet A,Barbet J,Paris F,Kraeber-Bodéré F

更新日期：2010-02-15 00:00:00

abstract：:The incidence of long thoracic nerve palsy after radical mastectomy has been documented to be approximately 10%. No cases have been reported after the more recent treatment for breast cancer, lumpectomy with axillary dissection. This more recent surgical procedure is customarily followed by aggressive radiation therap...

journal_title：Cancer

authors： Pugliese GN,Green RF,Antonacci A

更新日期：1987-09-15 00:00:00

abstract：:The orderly conduct of clinical research trials in pediatric oncology has laid the foundation for modern curative therapy in several childhood malignancies. Such types of large clinical trials are relatively new to pediatric neuro-oncology. New treatments such as single and combination chemotherapy agents are studied ...

journal_title：Cancer

authors： Allen JC

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Through this study, the authors sought to investigate the biologic and immunologic effects of preoperative trastuzumab in patients with ductal carcinoma in situ (DCIS) of the breast. METHODS:Patients with DCIS were enrolled in this open-label phase 2 trial and tested for HER2. Trastuzumab was given by intra...

journal_title：Cancer

authors： Kuerer HM,Buzdar AU,Mittendorf EA,Esteva FJ,Lucci A,Vence LM,Radvanyi L,Meric-Bernstam F,Hunt KK,Symmans WF

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Louisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a posi...

journal_title：Cancer

authors： Chu QD,Li T,Hsieh MC,Yi Y,Gibbs JF,Lyons JM 3rd,Wu XC

更新日期：2020-11-03 00:00:00

abstract：:Indirect data supporting a preexisting immunologic impairment in patients with Hodgkin's disease (HD) have been presented in recent years. These immunologic defects are supposed to be related to genetic and/or environmental factors. In this study, 65 first-degree relatives and 12 spouses of 21 consecutive patients wit...

journal_title：Cancer

authors： Merk K,Björkholm M,Tullgren O,Mellstedt H,Holm G

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The malignant biological behavior of small-sized lung adenocarcinomas remains obscure, although understanding this feature is important for selecting appropriate treatment. In the current study, the authors evaluated malignancy grades of small adenocarcinomas using fluorodeoxyglucose-positron emission tomogr...

journal_title：Cancer

authors： Nakayama H,Okumura S,Daisaki H,Kato Y,Uehara H,Adachi S,Yoshimura M,Okada M

更新日期：2010-07-01 00:00:00

abstract：:Because increased effects have been achieved when murine tumors are irradiated after a period of hypoxia and because of anecdotal clinical experiences of an improved result after irradiation of previously anemic patients in hyperbaric oxygen, the relationship between irradiation and increased survival was investigated...

journal_title：Cancer

authors： Sealy R,Jacobs P,Wood L,Levin W,Barry L,Boniaszczuk J,Blekkenhorst G

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...

journal_title：Cancer

authors： Sève P,Billotey C,Broussolle C,Dumontet C,Mackey JR

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:The objective of the current study was to examine the impact of adherence to guidelines on stage-specific survival outcomes in patients with stage III and high-risk stage II colon cancer. The National Comprehensive Cancer Network (NCCN) has established working, expert consensus, and evidence-based guidelines...

journal_title：Cancer

authors： Boland GM,Chang GJ,Haynes AB,Chiang YJ,Chagpar R,Xing Y,Hu CY,Feig BW,You YN,Cormier JN

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may b...

journal_title：Cancer

authors： Li F,Sturgis EM,Chen X,Zafereo ME,Wei Q,Li G

更新日期：2010-05-15 00:00:00

abstract：:Forty patients with disseminated malignant melanoma were treated with triple combination chemotherapy consisting of Imidazole Carboxamide, BCNU and Vincristine. Seventeen of 40 patients (42.5%) showed significant responses including three complete responses. Responses were seen in cutaneous, lymph node and pulmonary m...

journal_title：Cancer

authors： Cohen SM,Greenspan EM,Ratner LH,Weiner MJ

更新日期：1977-01-01 00:00:00