Abstract:
:Because increased effects have been achieved when murine tumors are irradiated after a period of hypoxia and because of anecdotal clinical experiences of an improved result after irradiation of previously anemic patients in hyperbaric oxygen, the relationship between irradiation and increased survival was investigated in seventy-two patients with advanced head and neck or cervical cancer. Anemia was achieved by means of a two-stage isovolemic venesection maintained for seventy-two hours, hemoglobin was returned to a normal level, and treatment in hyperbaric oxygen was started. Marked tumor shrinkage after the induction of anemia and before radiotherapy was seen and was probably disease, site, and hemoglobin level related. As a result, a possible new approach to cancer therapy is suggested. After completion of therapy, the 1-year disease-free survival for patients with head and neck and cervical cancer was not improved, but the 21-month survival for cervical cancer was improved. Further studies are strongly urged.
journal_name
Cancerjournal_title
Cancerauthors
Sealy R,Jacobs P,Wood L,Levin W,Barry L,Boniaszczuk J,Blekkenhorst Gdoi
10.1002/1097-0142(19890801)64:3<646::aid-cncr28206subject
Has Abstractpub_date
1989-08-01 00:00:00pages
646-52issue
3eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
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