Immunotherapy of metastatic renal cell carcinoma.

abstract：:Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...

journal_title：Cancer

authors： Poplack DG,Balis FM,Zimm S

更新日期：1986-07-15 00:00:00

abstract：BACKGROUND:The performance of cytologic screening and its correlation with histology and polymerase chain reaction (PCR) detection of human papillomavirus (HPV) DNA have not been evaluated in populations with a low prevalence of anal intraepithelial neoplasia (AIN). The objective of the current study was to analyze the...

journal_title：Cancer

authors： Etienney I,Vuong S,Si-Mohamed A,Fléjou JF,Atienza P,Bauer P,Cytological Diaconesses Group.

更新日期：2012-12-15 00:00:00

abstract：:Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...

journal_title：Cancer

authors： Krupp P,Bohm JW,Lee FY,Collins JH

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:In animal models carbogen (normobaric 95% oxygen, 5% carbon dioxide) provides significant enhancement of local tumor control with fractionated radiotherapy. This approach to radiosensitization has been evaluated in the treatment of patients with bladder carcinoma using radical radiotherapy. METHODS:Sixty-on...

journal_title：Cancer

authors： Hoskin PJ,Saunders MI,Dische S

更新日期：1999-10-01 00:00:00

abstract：:Basal cell carcinomas (BCCs) obtained from 22 subjects undergoing microscopically controlled surgery were transplanted to 40 athymic (nude) mice. With no further immunosuppression of the mice, no tumor growth was noted in the first 14 attempts. When mice were further immunosuppressed with anti-lymphocyte serum (ALS) i...

journal_title：Cancer

authors： Grimwood RE,Johnson CA,Ferris CF,Mercill DB,Mellette JR,Huff JC

更新日期：1985-08-01 00:00:00

abstract：:High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One ...

journal_title：Cancer

authors： Ambinder EP,Perloff M,Ohnuma T,Biller HF,Holland JF

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Primary myelofibrosis (PMF) and overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosin...

journal_title：Cancer

authors： Bejanyan N,Tiu RV,Raza A,Jankowska A,Kalaycio M,Advani A,Chan J,Saunthararajah Y,Mooney L,Maciejewski JP,Sekeres MA

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify genome-wide single nucleotide variants and mutations in African American patients with colorectal cancer (CRC). There is a need of such studies in African Americans, because they display a higher incidence of aggressive CRC tumors. METHODS:We performed whole exome s...

journal_title：Cancer

authors： Ashktorab H,Daremipouran M,Devaney J,Varma S,Rahi H,Lee E,Shokrani B,Schwartz R,Nickerson ML,Brim H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...

journal_title：Cancer

authors： Goldstein AM,Stidd KC,Yang XR,Fraser MC,Tucker MA

更新日期：2018-09-15 00:00:00

abstract：:Mesenchymal chondrosarcoma, an uncommon lesion of bone and extraskeletal tissue, is rare in the orbit. A case of extraskeletal mesenchymal chondrosarcoma of the orbit in a 28-year-old woman presenting with proptosis and diminution of vision in the left eye is reported. Histologically, the tumor showed areas of undiffe...

journal_title：Cancer

authors： Bagchi M,Husain N,Goel MM,Agrawal PK,Bhatt S

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:A crossover in breast carcinoma incidence at ages 45-49 years has been observed between black and white women, with blacks experiencing higher incidence at younger ages and lower incidence after age 50 years. Can this phenomenon be partially explained by the differences in the distributions of reproductive r...

journal_title：Cancer

authors： Pathak DR,Osuch JR,He J

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Social needs may affect cancer survivors' health-related quality of life (HRQOL) above and beyond sociodemographic and cancer-related factors. The purpose of this study was to estimate associations between social needs and HRQOL. METHODS:Results included data from 1754 participants in the Detroit Research o...

journal_title：Cancer

authors： Hastert TA,McDougall JA,Strayhorn SM,Nair M,Beebe-Dimmer JL,Schwartz AG

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...

journal_title：Cancer

authors： Vey N,Coso D,Bardou VJ,Stoppa AM,Braud AC,Bouabdallah R,Sainty D,Mozziconacci MJ,Lafage M,Damaj G,Blaise D,Gastaut JA,Maraninchi D

更新日期：2004-07-15 00:00:00

abstract：:Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

journal_title：Cancer

authors： Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

更新日期：1985-06-15 00:00:00

abstract：BACKGROUND:Mortality from invasive bladder cancer is common, even with high-quality care. Thus, the best opportunities to improve outcomes may precede the diagnosis. Although screening currently is not recommended, better medical care of patients who are at risk (ie, those with hematuria) has the potential to improve o...

journal_title：Cancer

authors： Hollenbeck BK,Dunn RL,Ye Z,Hollingsworth JM,Skolarus TA,Kim SP,Montie JE,Lee CT,Wood DP Jr,Miller DC

更新日期：2010-11-15 00:00:00

abstract：:Esophageal dilation by means of guided Neoplex (Medoc) tubes in 38 patients with malignant obstruction of the esophagus was analyzed. Peroral dilation proved to be a simple, well-tolerated primary procedure in the management of malignant strictures. Most patients have a temporary improvement of dysphagic symptoms, but...

journal_title：Cancer

authors： Aste H,Munizzi F,Martines H,Pugliese V

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:The prognostic significance and optimal care of children with differentiated thyroid cancer and pulmonary metastases are not well established. METHODS:Of 209 patients younger than 25 years of age who were treated at University of Texas M. D. Anderson Cancer Center between 1960 and 1990 and for whom there wa...

journal_title：Cancer

authors： Vassilopoulou-Sellin R,Klein MJ,Smith TH,Samaan NA,Frankenthaler RA,Goepfert H,Cangir A,Haynie TP

更新日期：1993-02-15 00:00:00

abstract：BACKGROUND:A study was undertaken to evaluate results of surgery and radiotherapy (RT) for high-risk extracranial chondrosarcomas. METHODS:Between 1986 and 2006, 60 patients underwent surgery and RT for extracranial high-risk chondrosarcoma. Preoperative RT (median, 50 gray [Gy]) and postoperative RT (median, 60 Gy) w...

journal_title：Cancer

authors： Goda JS,Ferguson PC,O'Sullivan B,Catton CN,Griffin AM,Wunder JS,Bell RS,Kandel RA,Chung PW

更新日期：2011-06-01 00:00:00

abstract：:Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the sec...

journal_title：Cancer

authors： Berman TA,Schiller JT

更新日期：2017-06-15 00:00:00

abstract：:Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was dete...

journal_title：Cancer

authors： Martin EW Jr,James KK,Hurtubise PE,Catalano P,Minton JP

更新日期：1977-02-01 00:00:00

abstract：:Acid phosphatase activity biochemically in the primary tumor of 20 patients with prostatic carcinoma, was studied in an attempt to understand the basis for a correlation or lack of correlation between serum and/or bone marrow acid phosphatase levels and the presence and/or clinical behavior of prostatic carcinoma. The...

journal_title：Cancer

authors： Copland GT,Whitehurst GB,Pretlow TP,Boohaker EA,Bartolucci AA,Pretlow TG 2nd

更新日期：1983-07-01 00:00:00

abstract：:Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...

journal_title：Cancer

authors： Bartolucci AA,Liu C,Durant JR,Gams RA

更新日期：1983-12-15 00:00:00

abstract：:A family with histopathologically proven intraocular malignant melanoma involving two generations is reported. A member of third generation was likely involved by history. Intraocular malignant melanoma, its familial occurrence, its occurrence with multiple malignancies, and its relationship to multiple malignancies o...

journal_title：Cancer

authors： Green GJ,Hong WK,Everett JR,Bhutani R,Amick RM

更新日期：1978-06-01 00:00:00

abstract：:Clear cell sarcoma is an indolent tumor of uncertain histogenesis. Twenty-seven patients ranging in age from 9 to 57 years (average, 28.5 years) were followed an average of 7.0 years. Females outnumbered males by 2 to 1. Distal extremity locations predominated. At presentation, the tumor was localized in 21 patients, ...

journal_title：Cancer

authors： Eckardt JJ,Pritchard DJ,Soule EH

更新日期：1983-10-15 00:00:00

abstract：:The clinical experience and technologic improvements of the past 40 years are briefly summarized in terms of their contributions to the present optimistic and aggressive approach to the treatment of malignant lymphoma. The reasoning behind the large-field moderately high-dose technique that has evolved is reviewed and...

journal_title：Cancer

authors： Nobler MP

更新日期：1968-10-01 00:00:00

abstract：:Based on Church records for 15,500 California Mormons during 1968 to 1975 and for 55,000 Utah Mormons during 1970 and 1975, the ratio of age-adjusted death rates for religiously active Mormon males compared with U.S. white males is 38% for ages 35 to 64 years and 50% for ages 35 years and above. The remaining life exp...

journal_title：Cancer

authors： Enstrom JE

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:The identification of the BRCA1 gene is a powerful tool for predicting a patient's lifetime risk for carcinoma of the breast and ovary when she has hereditary breast/ovarian carcinoma (HBOC) syndrome. The process of BRCA1 testing and genetic counseling and participants' reactions to test results, are describ...

journal_title：Cancer

authors： Lynch HT,Lemon SJ,Durham C,Tinley ST,Connolly C,Lynch JF,Surdam J,Orinion E,Slominski-Caster S,Watson P,Lerman C,Tonin P,Lenoir G,Serova O,Narod S

更新日期：1997-06-01 00:00:00

abstract：:Non-Hodgkin's lymphoma confined to the liver is unusual in adults and has not been reported in children. Two children with primary hepatic and one with hepatosplenic NHL are described. All three patients are males, and both tumors examined for cell surface markers were of B-cell origin. Two patients, treated with chem...

journal_title：Cancer

authors： Miller ST,Wollner N,Meyers PA,Exelby P,Jereb B,Miller DR

更新日期：1983-12-15 00:00:00

abstract：BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...

journal_title：Cancer

authors： Uematsu M,Shioda A,Tahara K,Fukui T,Yamamoto F,Tsumatori G,Ozeki Y,Aoki T,Watanabe M,Kusano S

更新日期：1998-03-15 00:00:00

abstract：:Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is ...

journal_title：Cancer

authors： Buzanowski-Konakry K,Harrison EG Jr,Payne WS

更新日期：1975-02-01 00:00:00