The use of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures.

Abstract:

:Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was determined and graphed as a CEA NOMOGRAM, which measures the observed CEA level against the 95% confidence limits for that observation and thus can be used to identify statistically significant increases. A statistically significant rise above a baseline value established by the NOMOGRAM proved to be a correct indicator of tumor recurrence in 22 (88%) of 25 patients who underwent second-look intraabdominal operations (22 colorectal, 2 gastric, and 1 pancreatic). In each case, other accepted procedures, such as liver enzymes, scans, and x-rays, were nondiagnostic. Of the 22 patients with proved tumor recurrence, 16 (73%) had distant metastases and 6 (27%) had localized tumors. One patient remains tumor-free three years after second-look operation and has had no significant change in CEA levels. More frequent serial CEA determinations combined with sound clinical judgment should facilitate earlier detection of recurrent gastrointestinal cancer.

journal_name

Cancer

journal_title

Cancer

authors

Martin EW Jr,James KK,Hurtubise PE,Catalano P,Minton JP

doi

10.1002/1097-0142(197702)39:2<440::aid-cncr2820390

subject

Has Abstract

pub_date

1977-02-01 00:00:00

pages

440-6

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

39

pub_type

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