Abstract:
:Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients showed typical flower cells in peripheral blood; they comprised five cases of the smoldering type and one of lymphoma type. They showed a longer clinical course than ATLL patients with integrated proviral HTLV-I DNA. Five of the six patients were alive from 8 to 36 months after onset; the other patient died 9 months after onset. Histologically, they exhibited features of T-cell malignancy but with absence of the typical cerebriform giant cells that are usually present in ATLL. The tumor cells represented T-cell markers, usually CD4, but CD25 was negative. Rearrangement of the T-cell receptor gene C beta was found in four of the six cases. On the basis of these results, cases of ATLL with no monoclonal proviral HTLV-I DNA should be clinicopathologically differentiated from those with integrated proviral DNA.
journal_name
Cancerjournal_title
Cancerauthors
Yoshida T,Kikuchi M,Ooshima K,Takeshita M,Kimura N,Kozuru M,Satoh Hdoi
10.1002/1097-0142(19891215)64:12<2515::aid-cncr282subject
Has Abstractpub_date
1989-12-15 00:00:00pages
2515-24issue
12eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
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