Anti-human T-cell lymphotrophic virus type I antibody-positive adult T-cell leukemia/lymphoma with no monoclonal proviral DNA. A clinicopathologic and immunologic study.

Abstract:

:Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients showed typical flower cells in peripheral blood; they comprised five cases of the smoldering type and one of lymphoma type. They showed a longer clinical course than ATLL patients with integrated proviral HTLV-I DNA. Five of the six patients were alive from 8 to 36 months after onset; the other patient died 9 months after onset. Histologically, they exhibited features of T-cell malignancy but with absence of the typical cerebriform giant cells that are usually present in ATLL. The tumor cells represented T-cell markers, usually CD4, but CD25 was negative. Rearrangement of the T-cell receptor gene C beta was found in four of the six cases. On the basis of these results, cases of ATLL with no monoclonal proviral HTLV-I DNA should be clinicopathologically differentiated from those with integrated proviral DNA.

journal_name

Cancer

journal_title

Cancer

authors

Yoshida T,Kikuchi M,Ooshima K,Takeshita M,Kimura N,Kozuru M,Satoh H

doi

10.1002/1097-0142(19891215)64:12<2515::aid-cncr282

subject

Has Abstract

pub_date

1989-12-15 00:00:00

pages

2515-24

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

64

pub_type

杂志文章

相关文献

CANCER文献大全
  • Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior.

    abstract::Since primary lymphoma of bone (PLB) exhibits morphologic diversity and variability in individual survival, we analyzed the relationship between histopathologic features and biological behavior in 33 patients treated at the Massachusetts General Hospital. Three major histologic subgroups were identified, based on a va...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820901)50:5<1009::aid-cncr2820

    authors: Dosoretz DE,Raymond AK,Murphy GF,Doppke KP,Schiller AL,Wang CC,Suit HD

    更新日期:1982-09-01 00:00:00

  • Thin-needle aspiration biopsy: the diagnosis of head and neck tumors revisited.

    abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1541::aid-cncr282043

    authors: Frable WJ,Frable MA

    更新日期:1979-04-01 00:00:00

  • Guideline-concordant cancer care and survival among American Indian/Alaskan Native patients.

    abstract:BACKGROUND:American Indians/Alaskan Natives (AI/ANs) have the worst 5-year cancer survival of all racial/ethnic groups in the United States. Causes for this disparity are unknown. The authors of this report examined the receipt of cancer treatment among AI/AN patients compared with white patients. METHODS:This was a r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28683

    authors: Javid SH,Varghese TK,Morris AM,Porter MP,He H,Buchwald D,Flum DR,Collaborative to Improve Native Cancer Outcomes (CINCO).

    更新日期:2014-07-15 00:00:00

  • Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors.

    abstract::The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(197604)37:4<1869::aid-cncr282037

    authors: Brooks WH,Roszman TL,Rogers AS

    更新日期:1976-04-01 00:00:00

  • Resting and activity energy expenditure during total parenteral nutrition in rats with methylcholanthrene-induced sarcoma.

    abstract::Tumor weight, carcass weight, nitrogen balance, energy balance, resting energy expenditure (REE), and activity energy expenditure (AEE) were measured in normal Fischer 344 rats, free-feeding Fischer 344 rats with methylcholanthrene-induced sarcoma (TB-FF), and similar tumor-bearing rats supported with total parenteral...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1212::aid-cncr2820

    authors: Popp MB,Brennan MF,Morrison SD

    更新日期:1982-03-15 00:00:00

  • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system.

    abstract:BACKGROUND:An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum EGFR scoring system. METHODS:Tissue sections from 102 patients with T3N1-2M1 colon adenocarcino...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010901)92:5<1331::aid-cncr1455

    authors: Goldstein NS,Armin M

    更新日期:2001-09-01 00:00:00

  • An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma.

    abstract::The altered expression of the human retinoblastoma (RB) gene has been demonstrated to play an important role in the pathogenesis of RB and other tumors. To determine whether the RB gene might be involved in the pathogenesis of human ovarian and endometrial cancer, DNA from 24 human ovarian tumors, 3 normal ovaries, 3 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2150::aid-cncr282

    authors: Sasano H,Comerford J,Silverberg SG,Garrett CT

    更新日期:1990-11-15 00:00:00

  • Triple-negative breast cancer in Hispanic patients: high prevalence, poor prognosis, and association with menopausal status, body mass index, and parity.

    abstract:BACKGROUND:Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25961

    authors: Lara-Medina F,Pérez-Sánchez V,Saavedra-Pérez D,Blake-Cerda M,Arce C,Motola-Kuba D,Villarreal-Garza C,González-Angulo AM,Bargalló E,Aguilar JL,Mohar A,Arrieta Ó

    更新日期:2011-08-15 00:00:00

  • Pulmonary toxicity of mitomycin.

    abstract::Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800115)45:2<236::aid-cncr28204

    authors: Buzdar AU,Legha SS,Luna MA,Tashima CK,Hortobagyi GN,Blumenschein GR

    更新日期:1980-01-15 00:00:00

  • Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases.

    abstract::A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor saliva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<388::aid-cncr2820390

    authors: Spiro RH,Huvos AG,Strong EW

    更新日期:1977-02-01 00:00:00

  • Acute myocardial infarction with normal coronary arteriogram after mantle field radiation therapy for Hodgkin's disease.

    abstract::A case of an acute myocardial infarction occurring in a 19-year-old woman, 27 months after mantle radiotherapy for Stage II-A Hodgkin's disease is described. The coronary arteriogram demonstrated patent and normal coronary arteries, but the echocardiogram revealed pericarditis. The clinical course was further complica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830815)52:4<637::aid-cncr28205

    authors: Yahalom J,Hasin Y,Fuks Z

    更新日期:1983-08-15 00:00:00

  • Clinical significance of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma.

    abstract:BACKGROUND:Vascular endothelial growth factor-C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor-3 (VEGFR-3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF-C and VEGFR...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21366

    authors: Kojima H,Shijubo N,Yamada G,Ichimiya S,Abe S,Satoh M,Sato N

    更新日期:2005-10-15 00:00:00

  • The impact of pulmonary infections on the survival of lung cancer patients.

    abstract::To determine the impact of pulmonary infections on survival in patients with lung cancer, a retrospective review of the records of 121 such patients treated at Howard University Hospital in Washington, DC, was done. There were 77 men and 44 women; 118 were black. The mean age was 63.5 years. Forty-three patients had s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900801)66:3<593::aid-cncr28206

    authors: Perlin E,Bang KM,Shah A,Hursey PD,Whittingham WL,Hashmi K,Campbell L,Kassim OO

    更新日期:1990-08-01 00:00:00

  • Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder.

    abstract:BACKGROUND:Transitional cell carcinoma (TCC) of the bladder displays an unpredictable biologic behavior and the morphologic methods of grading tumor malignancy are often insufficient to predict the clinical outcome of patients with TCC of the bladder. Thus, the new indicator should reliably reflect prognosis. In this s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19961015)78:8<1762::aid-cn

    authors: Shiina H,Igawa M,Nagami H,Yagi H,Urakami S,Yoneda T,Shirakawa H,Ishibe T,Kawanishi M

    更新日期:1996-10-15 00:00:00

  • A possible association between ionizing radiation and pituitary adenoma: a descriptive study.

    abstract:BACKGROUND:Despite the recognition of ionizing radiation as a causal risk factor for a variety of solid tumors (including brain tumors), to date, such an association with pituitary adenoma (PA) has not been demonstrated. METHODS:To evaluate a possible association between past exposure to radiation and the occurrence o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.10667

    authors: Juven Y,Sadetzki S

    更新日期:2002-07-15 00:00:00

  • Stage and mortality of low-income patients with cancer: Evidence from SEER-Medicaid.

    abstract:BACKGROUND:A national data source for identifying patients with cancer enrolled in Medicaid is needed to evaluate cancer care for low-income, publicly insured patients. In this study, a population-based data set of patients diagnosed with cancer and enrolled in Medicaid was created and evaluated. The objective was to c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33207

    authors: Bradley CJ,Stevens JL,Enewold L,Warren JL

    更新日期:2021-01-15 00:00:00

  • Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma.

    abstract:BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24922

    authors: Spina M,Chimienti E,Martellotta F,Vaccher E,Berretta M,Zanet E,Lleshi A,Canzonieri V,Bulian P,Tirelli U

    更新日期:2010-03-15 00:00:00

  • Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.

    abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25826

    authors: Seidinger AL,Mastellaro MJ,Paschoal Fortes F,Godoy Assumpção J,Aparecida Cardinalli I,Aparecida Ganazza M,Correa Ribeiro R,Brandalise SR,Dos Santos Aguiar S,Yunes JA

    更新日期:2011-05-15 00:00:00

  • Glycosaminoglycan in malignant pleural mesothelioma.

    abstract::The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 tim...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860101)57:1<106::aid-cncr28205

    authors: Nakano T,Fujii J,Tamura S,Amuro Y,Nabeshima K,Horai T,Hada T,Higashino K

    更新日期:1986-01-01 00:00:00

  • The prognostic impact of cyclin dependent kinase inhibitors p21WAF1, p27Kip1, and p16INK4/MTS1 in adenocarcinomas of the uterine cervix: an immunohistochemical evaluation of expression patterns in population-based material from 142 patients with internati

    abstract:BACKGROUND:The authors assessed the prognostic significance of abnormal cyclin dependent kinase inhibitor (CDKI) expression in adenocarcinomas of the uterine cervix. METHODS:Population-based, archival material from patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I and II cervical adeno...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11727

    authors: Alfsen GC,Reed W,Sandstad B,Kristensen GB,Abeler VM

    更新日期:2003-11-01 00:00:00

  • Pathoradiologic correlation of pulmonary candidiasis in immunosuppressed patients.

    abstract::The diagnosis of pulmonary candidiasis can only be made with certainty when tissue invasion by the organism is demonstrated histologically. In order to ascertain whether characteristic radiographic patterns are seen in patients with pulmonary candidiasis, antemortem radiographic abnormalities were correlated with auto...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197709)40:3<1026::aid-cncr282040

    authors: Dubois PJ,Myerowitz RL,Allen CM

    更新日期:1977-09-01 00:00:00

  • Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.

    abstract:BACKGROUND:A previous comparative tissue proteomics study by the authors of the current study led to the identification of caldesmon (CaD) as one of the proteins associated with cervical metastasis of oral cavity squamous cell carcinoma (OSCC). In the current investigation, the authors focused on the potential function...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28300

    authors: Chang KP,Wang CL,Kao HK,Liang Y,Liu SC,Huang LL,Hseuh C,Hsieh YJ,Chien KY,Chang YS,Yu JS,Chi LM

    更新日期:2013-11-15 00:00:00

  • The use of prognostic factors in clinical trials.

    abstract::Numerous examples exist of prognostic factors that have been conclusively established and that can segregate the target patient population into subgroups with vastly different outcomes. At the same time, we can expect, in the majority of trials being conducted, that if a new treatment turns out to be successful, it ge...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860715)58:2+<461::aid-cncr2820

    authors: Sather HN

    更新日期:1986-07-15 00:00:00

  • Cancer-related fatigue: implications for breast cancer survivors.

    abstract::Cancer-related fatigue (CRF) has been documented as 1 of the most distressing symptoms reported by breast cancer survivors. CRF affects functioning and impacts quality of life. Possible causal factors include physical conditions, affective and cognitive states, proinflammatory cytokines, and metabolic factors. Several...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.27475

    authors: Berger AM,Gerber LH,Mayer DK

    更新日期:2012-04-15 00:00:00

  • Vascular endothelial growth factor-targeted therapy for the treatment of adult metastatic Xp11.2 translocation renal cell carcinoma.

    abstract:BACKGROUND:Adult "translocation" renal cell carcinoma (RCC), bearing transcription factor E3 (TFE3) gene fusions at Xp11.2, is a recently recognized, unique entity for which prognosis and therapy remain poorly understood. In the current study, the authors investigated the effect of vascular endothelial growth factor (V...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25512

    authors: Choueiri TK,Lim ZD,Hirsch MS,Tamboli P,Jonasch E,McDermott DF,Dal Cin P,Corn P,Vaishampayan U,Heng DY,Tannir NM

    更新日期:2010-11-15 00:00:00

  • A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome.

    abstract:BACKGROUND:Because angiogenesis may play a role in the pathogenesis of acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS), and thalidomide (Th) has shown significant anti-angiogenic activity, this study was designed to investigate the potential role of Th in the treatment of patients with AML and...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11180

    authors: Cortes J,Kantarjian H,Albitar M,Thomas D,Faderl S,Koller C,Garcia-Manero G,Giles F,Andreeff M,O'Brien S,Keating M,Estey E

    更新日期:2003-03-01 00:00:00

  • Lymphocyte predominance Hodgkin's disease. A clinicopathologic reassessment.

    abstract::A clinicopathologic analysis of 35 cases of lymphocyte predominance Hodgkin's disease (LPHD) was performed, and the relationship between various histologic features and stage at presentation was examined. The series comprised 31 male and 4 female patients with a median age of 32 years. Twenty patients had Ann Arbor St...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870101)59:1<99::aid-cncr282059

    authors: Trudel MA,Krikorian JG,Neiman RS

    更新日期:1987-01-01 00:00:00

  • Tackling the cancer signal transduction “labyrinth”: a combinatorial use of biochemical tools with mathematical models will enhance the identification of optimal targets for each molecular defect.

    abstract::Unraveling cancer-associated molecular defects is crucial for further pharmacological targeting. Although novel techniques are being developed to elucidate genomic, proteomic, and transcriptomic alterations, the map of protein interactions and aberrations in normal but also in malignant cells is still obscure. It has ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28424

    authors: Karamouzis MV,Papavassiliou AG

    更新日期:2014-02-01 00:00:00

  • Ultrastructural studies of xenografted human germ cell tumors.

    abstract::Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820215)49:4<683::aid-cncr28204

    authors: Monaghan P,Raghavan D,Neville AM

    更新日期:1982-02-15 00:00:00

  • Hiccups with high dose dexamethasone administration: a case report.

    abstract:BACKGROUND:A 59-year-old male developed intractable hiccups during monthly therapy with high dose dexamethasone for multiple myeloma. Hiccups would begin hours after his first dose and continue over the 4 days of therapy. He sought assistance after his attempt at home remedies failed and the hiccups became exhausting. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980115)82:2<415::aid-cnc

    authors: Cersosimo RJ,Brophy MT

    更新日期:1998-01-15 00:00:00