Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior.

Abstract:

:Since primary lymphoma of bone (PLB) exhibits morphologic diversity and variability in individual survival, we analyzed the relationship between histopathologic features and biological behavior in 33 patients treated at the Massachusetts General Hospital. Three major histologic subgroups were identified, based on a variety of criteria, the most important of which were the predominance of cells with or without nuclear clefts and the degree of pleomorphism. The probability of NED survival at five years was 64% for patients with tumor predominantly composed of cleaved cells, 13% for those with tumors classified in the noncleaved cell tumor group, and 0% (no survivors) for the pleomorphic subgroup. When tumors were subclassified according to the size of the predominant cell (small versus large), this parameter was found to be of no value in preceding NED survival. Factors that could have potentially influenced the results were analyzed. Since this is a retrospective review, the questions addressed in this study should be further studied in a prospective way.

journal_name

Cancer

journal_title

Cancer

authors

Dosoretz DE,Raymond AK,Murphy GF,Doppke KP,Schiller AL,Wang CC,Suit HD

doi

10.1002/1097-0142(19820901)50:5<1009::aid-cncr2820

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

1009-14

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

50

pub_type

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