Resting and activity energy expenditure during total parenteral nutrition in rats with methylcholanthrene-induced sarcoma.

Abstract:

:Tumor weight, carcass weight, nitrogen balance, energy balance, resting energy expenditure (REE), and activity energy expenditure (AEE) were measured in normal Fischer 344 rats, free-feeding Fischer 344 rats with methylcholanthrene-induced sarcoma (TB-FF), and similar tumor-bearing rats supported with total parenteral nutrition (TB-TPN). TB-FF rats became hypophagic and demonstrated weight loss, negative nitrogen balance, and negative energy balance as the tumor enlarged. TB-FF rats had a normal FEE and AEE when tumors were small and a decreased REE and AEE when tumors were large. TB-TPN rats were maintained in positive nitrogen and energy balance. TB-TPN rats had significantly increased REE throughout the study and a decreased AEE at the end of the study. Both the host carcass and the tumor responded to increased nutritional substrate with increased growth. The decline in motor activity which characterizes cancer cachexia may not be totally dependent on malnutrition.

journal_name

Cancer

journal_title

Cancer

authors

Popp MB,Brennan MF,Morrison SD

doi

10.1002/1097-0142(19820315)49:6<1212::aid-cncr2820

subject

Has Abstract

pub_date

1982-03-15 00:00:00

pages

1212-20

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

49

pub_type

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