Abstract:
:During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been increased. The present rate of 32% has been achieved with an overall 30-day operative mortality rate of 9%. More sophisticated intraoperative and postoperative supports have been essential in achieving these results. The median operating time is now 4 3/4 hours in length. Complications are minimal. The median postoperative hospital stay is now 13 days. During the past decade, 436 patients with liver tumors were treated by the authors. It has become apparent in this experience and in that reported by others that an increasing number of patients with primary liver cancer or metastatic cancer in the liver can be cured by surgery with minimal operative risk. Adjuvant chemotherapy may increase the salvage rate. Current therapeutic results are best evaluated after staging of the liver disease: Stage I (no involvement of margins of resection, hepatic vascular structures or bile ducts; all gross disease removed): 85% three-year survival estimate, using the Kaplan-Meier method, for individuals with primary liver cancer; 71% for those with metastatic colorectal cancer. Stages II and III (regional or extrahepatic spread): 22% three-year survival for individuals with primary liver cancer but no survivors at two years with metastatic colorectal cancer. These data permit better selection of patients who are most likely to benefit from surgery.
journal_name
Cancerjournal_title
Cancerauthors
Fortner JG,MacLean BJ,Kim DK,Howland WS,Turnbull AD,Goldiner P,Carlon G,Beattie EJ Jrdoi
10.1002/1097-0142(19810501)47:9<2162::aid-cncr2820subject
Has Abstractpub_date
1981-05-01 00:00:00pages
2162-6issue
9eissn
0008-543Xissn
1097-0142journal_volume
47pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS:We retrospectively analyzed a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10699
更新日期:2002-08-01 00:00:00
abstract::The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<285::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::The multiple classifications of histiocytic disorders, and the lack of specificity in their application, have degraded the utility of such diagnostic terms as "Letterer-Siwe Disease" and "Malignant Histiocytosis". A case is presented of a systemic histiocytic proliferation with erythrophagocytosis and giant-cell forma...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197612)38:6<2529::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract::A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1911::aid-cncr282
更新日期:1983-05-15 00:00:00
abstract::This article documents the study of 383 cases of lung cancer in uranium miners and presents for the first time the relationship of radioactive radon gas and cigarette smoking. There is evidence that alpha radiation from radon gas at exposure levels above 465 working level months (WLM) is a strong contributor to the de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1402::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract:LAY SUMMARY:During the coronavirus disease 2019 (COVID-19) pandemic, cancer screening decreased precipitously; home screening for colorectal cancer diminished less than that for colonoscopy and breast and cervical cancer screening. The authors have highlighted approaches for home cancer screening in addition to telemed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33274
更新日期:2021-02-15 00:00:00
abstract:BACKGROUND:The aim of this study was to determine and compare the added prognostic value of screening tools, geriatric assessment (GA) components, and GA summaries to clinical information for overall survival (OS) in older patients with cancer. METHODS:A screening and a 10-item GA were systematically performed in pati...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31581
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Angiogenesis in individuals with various solid tumors has provided useful information on tumor progression and prognosis, and many examples of mast cell (MC) accumulation coupled with angiogenesis can be found in the literature. METHODS:Utilizing monoclonal antibodies for tryptase that are specific markers ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-15 00:00:00
abstract::Lobular carcinoma in situ (LCIS) has uncertain malignant potential; biologic markers that will identify patients at risk for a poor clinical outcome have been sought actively. Amplification of the c-erbB-2 protooncogene has been correlated with poor prognosis in invasive mammary carcinoma, and immunohistochemical eval...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910715)68:2<331::aid-cncr28206
更新日期:1991-07-15 00:00:00
abstract:BACKGROUND:A higher total dose of radiation therapy administered in fractionated lower individual doses twice daily (hyperfractionated radiation therapy) has been reported to improve survival for children with brain stem gliomas. However, this higher dose of radiation therapy may cause more sequelae. METHOD:Eighty-eig...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19930415)71:8<2666::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871015)60:8<1842::aid-cncr2820
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:Gastrin-releasing peptide (GRP) is an autocrine growth factor in patients with small cell lung carcinoma (SCLC). The authors developed a reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the detection of SCLC cells in the peripheral blood and the pleural effusion using preproGRP mRNA as a ta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11378
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:The Ets-1 transcription factor has been proposed to play an important role in the invasive process of tumor cells through the induction of urokinase-type plasminogen activator (u-PA). METHODS:Because meningiomas are potentially invasive tumors, irrespective of their malignancy grades, the authors immunohist...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001201)89:11<2292::aid-cncr18>
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Ovarian tumors of borderline malignancy have a less aggressive behavior and tend to occur at a younger age than their invasive counterparts. The role and extent of fertility-sparing conservative treatments is under continuous evaluation. METHODS:The current study was a retrospective review of 82 patients wi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The cytogenetic findings in 31 liposarcomas from 26 patients are reported. Four other tumors did not grow. Three histologic types are represented in this analysis. The well-differentiated liposarcomas were characterized by telomeric associations, large marker chromosomes and ring chromosomes, and in some cases, double...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920515)69:10<2484::aid-cncr282
更新日期:1992-05-15 00:00:00
abstract::Five cases of primary intestinal lymphoma are described. The main clinical features included abdominal pain, diarrhea, and marked weight loss, together with radiologic and some laboratory findings suggestive of malabsorption. Laparatomy perfomed in four cases revealed dilatation of the small intestine, with mesenteric...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3<848::aid-cncr2820350
更新日期:1975-03-01 00:00:00
abstract::The dose of adjuvant chemotherapy for breast cancer may be an important factor in the success of the treatment program. In a retrospective analysis, the authors determined whether patients who were irradiated either postoperatively (N = 29) or as part of primary treatment (N = 13) received a lower dose of adjuvant cyc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840115)53:2<237::aid-cncr28205
更新日期:1984-01-15 00:00:00
abstract:BACKGROUND:Male breast cancer (MBC) is considered an androgen-dependent tumor, and as in prostatic cancer, responses have been reported with use of antiandrogens or gonadotropin-releasing hormone analogs. Thus, it is reasonable to postulate that better results could be achieved by combining these two agents. METHODS:E...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<502::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract::A 24-year-old woman was found to have a diffuse large cell lymphoma arising within thyroid tissue within a mature cystic teratoma of the ovary. To the authors' knowledge, this is the first reported case of malignant lymphoma arising within a teratoma of the ovary. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861201)58:11<2459::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Human neoplasms often are accompanied by an inflammatory infiltrate. It has been proposed that this represents an immunologic response to the tumor. Dysgerminoma, a germ cell tumor of the ovary, is a classic example of this phenomenon. The authors investigated the immunophenotype of the tumor-infiltrating ly...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930415)71:8<2562::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract::Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197806)41:6<2420::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:In spite of many reports, it remains unclear whether the presence of tumor cells in circulating blood flow predicts a poor prognosis. METHODS:Competitive seminested reverse transcriptase-polymerase chain reaction (RT-PCR), a technique for the quantitative detection of tumor cells, was applied to detect the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1251::aid-cncr1445
更新日期:2001-09-01 00:00:00
abstract::The prognostic significance of ploidy level was studied in prostatic carcinoma and compared with the prognostic significance of morphologic grade and clinical stage. A nonselected group of 145 patients was studied in whom prostatic carcinoma was diagnosed by fine-needle aspiration biopsy at the Karolinska Hospital in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1432::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:The effect on prognosis of adding imatinib mesylate to the treatment of patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) has not been explored fully. The objective of the current study was to evaluate the benefit of adding imatinib to the treatment sequence of patients w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11665
更新日期:2003-10-01 00:00:00
abstract::Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920515)69:10<2561::aid-cncr282
更新日期:1992-05-15 00:00:00
abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29360
更新日期:2015-08-01 00:00:00
abstract::The effect of cis-diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse-grown human tumors following administration of single-agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830801)52:3<452::aid-cncr28205
更新日期:1983-08-01 00:00:00
abstract::New approaches are needed in the treatment of advanced breast cancer. In vitro studies have shown that recombinant tumor necrosis factor (TNF) is a growth inhibitor for the MCF-7, ZR-75-1, and BT-20 human breast cancer cell lines. Based on these considerations, the Southwest Oncology Group performed a Phase II trial o...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19911015)68:8<1694::aid-cncr2820
更新日期:1991-10-15 00:00:00
abstract:BACKGROUND:There is global variation in the onset of hepatocellular carcinoma (HCC). The objective of the current study was to investigate the impact of country of birth on age at the time of HCC diagnosis in the United States. METHODS:Incident HCC cases diagnosed between 2000 and 2012 in the Surveillance, Epidemiolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30246
更新日期:2017-01-01 00:00:00