Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases.


:A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor salivary glands in 16 patients, and sublingual gland in one. In terms of our total experience, 11% of all submaxillary tumors proved to be of the malignant mixed variety as compared to 6% of parotid tumors and 3% of minor salivary tumors, respectively. Seventy-one patients (48%) had previously received therapy elsewhere. Results of treatment are presented and the factors which influenced the results are discussed.






Spiro RH,Huvos AG,Strong EW




Has Abstract


1977-02-01 00:00:00














  • Adenocarcinoma in situ of the cervix.

    abstract:BACKGROUND:The current study examines 1) the sensitivity of detection and 2) sampling and screening/diagnostic error in the cytologic diagnosis of adenocarcinoma in situ (AIS) of the cervix. The data were taken from public and private sector screening laboratories reporting 25,000 and 80,000 smears, respectively, each ...


    pub_type: 评论,杂志文章


    authors: Schoolland M,Segal A,Allpress S,Miranda A,Frost FA,Sterrett GF

    更新日期:2002-12-25 00:00:00

  • Parathyroid hormone-related protein expression in gynecic squamous carcinoma cells.

    abstract:BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...


    pub_type: 杂志文章


    authors: Tait DL,MacDonald PC,Casey ML

    更新日期:1994-03-01 00:00:00

  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...


    pub_type: 杂志文章


    authors: Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

    更新日期:2012-01-15 00:00:00

  • Leiomyosarcoma arising in an arteriovenous fistula.

    abstract::The case of a man who developed a leiomyosarcoma in association with a surgically created arteriovenous fistula is reported. This unusual complication of a dialysis fistula is the first reported case of a leiomyosarcoma occurring in a surgically created fistula. ...


    pub_type: 杂志文章


    authors: Weinreb W,Steinfeld A,Rodil J,Esparza A,Trebbin W

    更新日期:1983-07-15 00:00:00

  • Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls.

    abstract:BACKGROUND:This study examined the influence of prior treatment on the course of cognitive functioning in breast cancer survivors. Changes in cognitive functioning over time were compared in breast cancer survivors treated with chemotherapy plus radiotherapy, breast cancer survivors treated with radiotherapy only, and ...


    pub_type: 杂志文章


    authors: Phillips KM,Jim HS,Small BJ,Laronga C,Andrykowski MA,Jacobsen PB

    更新日期:2012-04-01 00:00:00

  • Use of concurrent chemotherapy, accelerated fractionation radiation, and surgery for patients with esophageal carcinoma.

    abstract:BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...


    pub_type: 临床试验,杂志文章


    authors: Adelstein DJ,Rice TW,Becker M,Larto MA,Kirby TJ,Koka A,Tefft M,Zuccaro G

    更新日期:1997-09-15 00:00:00

  • Nonrandom expression of polypeptide hormones in pancreatic endocrine tumors. An immunohistochemical study in a case of multiple islet cell neoplasia.

    abstract::One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumo...


    pub_type: 杂志文章


    authors: Pilato FP,D'Adda T,Banchini E,Bordi C

    更新日期:1988-05-01 00:00:00

  • Breast cancer and paraneoplastic cerebellar degeneration.

    abstract::Of the remote effects of cancer on the neurologic system, paraneoplastic cerebellar degeneration (PCD), characterized by global cerebellar dysfunction, is second only to paraneoplastic neuropathies in frequency. Recent evidence, including the finding of anti-Purkinje cell (now termed anti-Yo) antibodies directed again...


    pub_type: 杂志文章,评审


    authors: Waterhouse DM,Natale RB,Cody RL

    更新日期:1991-10-15 00:00:00

  • Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer: findings from the bolus, infusional, or capecitabine with camptostar-celecoxib study.

    abstract:BACKGROUND:Irinotecan-based chemotherapy regimens are 1 option for treatment of metastatic colorectal cancer (mCRC). The authors report the safety and efficacy of such regimens in elderly patients using a large phase III trial (bolus, infusional, or capecitabine with camptostar-celecoxib [BICC-C]) cohort. METHODS:In p...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jackson NA,Barrueco J,Soufi-Mahjoubi R,Marshall J,Mitchell E,Zhang X,Meyerhardt J

    更新日期:2009-06-15 00:00:00

  • The usefulness of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and a comparison of (18)F-FDG-pet with (67)gallium scintigraphy in the evaluation of lymphoma: relation to histologic subtypes based on the World Health Organization c

    abstract:BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...


    pub_type: 杂志文章


    authors: Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

    更新日期:2007-08-01 00:00:00

  • Malignant melanoma of the skin occurring during pregnancy.

    abstract::The clinical course of melanoma of the skin diagnosed during pregnancy was compared with a control population of women with melanoma that occurred during the childbearing years, as recorded by the Connecticut Tumor Registry. The survival at three and five years for the 12 patients whose melanoma developed during pregn...


    pub_type: 杂志文章


    authors: Houghton AN,Flannery J,Viola MV

    更新日期:1981-07-15 00:00:00

  • Biliary cystadenocarcinoma: Case report of hepatic malignancy originating in benign cystadenoma.

    abstract::A case of biliary cystadenoma undergoing malignant dedifferentiation is presented. Biliary cystadenocarcinoma is an infrequently occurring neoplasm; fewer than 20 cases have been reported in the literature. This case is the first in which there is documentation of cystadenocarcinoma arising from a previously diagnosed...


    pub_type: 杂志文章


    authors: Woods GL

    更新日期:1981-06-15 00:00:00

  • Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p.

    abstract:BACKGROUND:In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence-free survival. In the current study, the authors attempted to analyze 21 patients genetically and cli...


    pub_type: 杂志文章


    authors: Hashimoto N,Murakami M,Takahashi Y,Fujimoto M,Inazawa J,Mineura K

    更新日期:2003-05-01 00:00:00

  • The pathophysiology of lymphedema.

    abstract:BACKGROUND:All edemas result from an imbalance between capillary filtration and tissue (lymph) drainage. This basic approach was adopted to investigate mechanisms for chronic arm edema following breast carcinoma treatment. METHODS:A review of causes of lymphedema is presented plus the traditional pathophysiology of br...


    pub_type: 杂志文章,评审


    authors: Mortimer PS

    更新日期:1998-12-15 00:00:00

  • Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates.

    abstract::Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...


    pub_type: 杂志文章


    authors: Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

    更新日期:1991-10-01 00:00:00

  • The role of chemotherapy for node-negative breast cancer.

    abstract::Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...


    pub_type: 杂志文章,评审


    authors: Cooper MR

    更新日期:1991-03-15 00:00:00

  • Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma: carboplatin and gemcitabine followed by paclitaxel.

    abstract:BACKGROUND:The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (NSCLC) by the administration of carboplatin plus gemcitabine followed by of paclitaxel. METHODS:Patients with Stage IIIB (pleural effusion) or ...


    pub_type: 临床试验,杂志文章


    authors: Edelman MJ,Gandara DR,Lau DH,Lara P,Lauder IJ,Tracy D

    更新日期:2001-07-01 00:00:00

  • The T classification of clinically localized prostate cancer. An appraisal based on disease outcome after radiation therapy.

    abstract:BACKGROUND:This study was performed to evaluate the use of the 1992 International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) T categories for localized prostate cancer treated with radiation therapy and to compare the prognostic power of this system with the Whitmore-Jewett scheme. METHODS:T...


    pub_type: 杂志文章


    authors: Zagars GK,Geara FB,Pollack A,von Eschenbach AC

    更新日期:1994-04-01 00:00:00

  • Pathologic classification of prostate carcinoma: the impact of margin status.

    abstract:BACKGROUND:A proposed pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen (PSA) era. The impact of margin status on the survival outcome of patients with otherwise organ-confined disease (i.e., without extraprostatic extension o...


    pub_type: 杂志文章


    authors: Blute ML,Bostwick DG,Seay TM,Martin SK,Slezak JM,Bergstralh EJ,Zincke H

    更新日期:1998-03-01 00:00:00

  • Improved detection of focal lesions with computerized tomographic examination of the liver using ethiodized oil emulsion (EOE-13) liver contrast.

    abstract::A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC-CT), CT with water-soluble contrast (WSC-CT), and CT with ethiodized oil emulsion (EOE-CT) were performed on patients with possible or probab...


    pub_type: 杂志文章


    authors: Sugarbaker PH,Vermess M,Doppman JL,Miller DL,Simon R

    更新日期:1984-10-15 00:00:00

  • Prognostic factors in elderly women with metastatic breast cancer treated with tamoxifen: an analysis of patients entered on four prospective clinical trials.

    abstract:BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dhodapkar MV,Ingle JN,Cha SS,Mailliard JA,Wieand HS

    更新日期:1996-02-15 00:00:00

  • Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity.

    abstract:BACKGROUND:Oral leukoplakia is a premalignant lesion, but the genetic changes in the foci of early cancerization in leukoplakia have not been studied. METHODS:Loss of heterozygosity (LOH) was successively investigated in 13 cases in the leukoplakia and foci of early cancerization in the same leukoplakia. The authors m...


    pub_type: 杂志文章


    authors: Jiang WW,Fujii H,Shirai T,Mega H,Takagi M

    更新日期:2001-11-01 00:00:00

  • Serum p53 antibody is a useful tumor marker in superficial esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Patients with superficial (mucosal or submucosal) esophageal carcinoma (SEC) have significantly better survival rates than patients with advanced carcinoma. Some patients with advanced esophageal carcinoma have been reported to test positive for serum p53 antibodies (Abs). Because very few patients with supe...


    pub_type: 杂志文章


    authors: Shimada H,Takeda A,Arima M,Okazumi S,Matsubara H,Nabeya Y,Funami Y,Hayashi H,Gunji Y,Suzuki T,Kobayashi S,Ochiai T

    更新日期:2000-10-15 00:00:00

  • Association between race and follow-up diagnostic care after a positive prostate cancer screening test in the prostate, lung, colorectal, and ovarian cancer screening trial.

    abstract:BACKGROUND:Follow-through of a positive screening test is necessary to reap the potential benefits of cancer screening. Racial variation in follow-through diagnostic care may underlie a proportion of the known disparity in prostate cancer mortality. The authors used data from the screening arm of the Prostate, Lung, Co...


    pub_type: 杂志文章,随机对照试验


    authors: Barocas DA,Grubb R 3rd,Black A,Penson DF,Fowke JH,Andriole G,Crawford ED

    更新日期:2013-06-15 00:00:00

  • Trastuzumab emtansine with or without pertuzumab versus trastuzumab with taxane for human epidermal growth factor receptor 2-positive advanced breast cancer: Final results from MARIANNE.

    abstract:BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...


    pub_type: 杂志文章


    authors: Perez EA,Barrios C,Eiermann W,Toi M,Im YH,Conte P,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Petersen JA,De Haas S,Hoersch S,Patre M,Ellis PA

    更新日期:2019-11-15 00:00:00

  • Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine.

    abstract:BACKGROUND:Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent the cumulative damage that occurs in normal adult somatic cells during successive mitotic cycles. Recently, it has been proposed that this enzyme should, therefore, be detectable in immor...


    pub_type: 杂志文章


    authors: Yoshida K,Sugino T,Tahara H,Woodman A,Bolodeoku J,Nargund V,Fellows G,Goodison S,Tahara E,Tarin D

    更新日期:1997-01-15 00:00:00

  • Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

    abstract::A prospective study of patients receiving cis-diaminedichloroplatin II (DDP) was carried out to determine if risk factors could be identified related to the patient's living habits or past medical history that would predict in which patients DDP neuropathy might develop. Sixty-nine patients receiving six different com...


    pub_type: 杂志文章


    authors: Mollman JE,Glover DJ,Hogan WM,Furman RE

    更新日期:1988-06-01 00:00:00

  • Evaluation of fluorescence polarization of human blood lymphocytes (SCM test) in the diagnosis of cancer.

    abstract::Fluorescence polarization was performed on 82 individuals: 32 patients with malignant diseases, 30 apparently healthy individuals, and 20 patients with nonmalignant diseases. The blood lymphocytes from these cases were isolated and challenged with cancer basic protein (CaBP). Stimulation occurred in the majority of th...


    pub_type: 杂志文章


    authors: Schnuda ND

    更新日期:1980-09-01 00:00:00

  • The role of tumor resection in the treatment of glioblastoma multiforme in adults.

    abstract:BACKGROUND:The therapeutic impact of tumor resection is poorly defined. Therefore the current study was conducted. METHODS:A retrospective, 2-institutional study was conducted (1991-1994) to compare the treatment results of stereotactic biopsy plus radiation therapy (99 patients; tumor dose: 60 gray [Gy]) with those o...


    pub_type: 杂志文章,多中心研究


    authors: Kreth FW,Berlis A,Spiropoulou V,Faist M,Scheremet R,Rossner R,Volk B,Ostertag CB

    更新日期:1999-11-15 00:00:00

  • Isolated marrow lymphoma: an entity of possible T-cell derivation.

    abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...


    pub_type: 杂志文章


    authors: Barton JC,Conrad ME,Vogler LB,Parmley RT

    更新日期:1980-10-15 00:00:00