Pulmonary toxicity of mitomycin.

Abstract:

:Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary fibrosis. Corticosteroid therapy resulted in complete resolution of pneumonia in one patient. Respiratory symptoms improved in 3 patients following discontinuation of the drug. Two patients with extensive bilateral pneumonitis, who were not treated with steroids, died of respiratory failure. Mitomycin-induced lung toxicity appears to be reversible with the discontinuation of drug and the administration of corticosteroids. Lung biopsy is necessary in order to rule out other diagnoses.

journal_name

Cancer

journal_title

Cancer

authors

Buzdar AU,Legha SS,Luna MA,Tashima CK,Hortobagyi GN,Blumenschein GR

doi

10.1002/1097-0142(19800115)45:2<236::aid-cncr28204

subject

Has Abstract

pub_date

1980-01-15 00:00:00

pages

236-44

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

45

pub_type

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