Prolactin cell carcinoma of the pituitary. Clinicopathologic, immunohistochemical, and ultrastructural study of a case with cranial and extracranial metastases.

Abstract:

:A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immunohistochemical studies demonstrated prolactin in the cytoplasm of primary and metastatic tumor cells. Ultrastructural features of lactotrophic differentiation, including misplaced granule exocytosis, were observed. This is the third reported case of prolactin cell carcinoma that metastasized despite high-dose dopamine agonist therapy. Analysis of the patient's serum prolactin showed no abnormality in the chromatographic profile of biologic activity.

journal_name

Cancer

journal_title

Cancer

authors

Scheithauer BW,Randall RV,Laws ER Jr,Kovacs KT,Horvath E,Whitaker MD

doi

10.1002/1097-0142(19850201)55:3<598::aid-cncr28205

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

598-604

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

55

pub_type

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