Abstract:
:A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immunohistochemical studies demonstrated prolactin in the cytoplasm of primary and metastatic tumor cells. Ultrastructural features of lactotrophic differentiation, including misplaced granule exocytosis, were observed. This is the third reported case of prolactin cell carcinoma that metastasized despite high-dose dopamine agonist therapy. Analysis of the patient's serum prolactin showed no abnormality in the chromatographic profile of biologic activity.
journal_name
Cancerjournal_title
Cancerauthors
Scheithauer BW,Randall RV,Laws ER Jr,Kovacs KT,Horvath E,Whitaker MDdoi
10.1002/1097-0142(19850201)55:3<598::aid-cncr28205subject
Has Abstractpub_date
1985-02-01 00:00:00pages
598-604issue
3eissn
0008-543Xissn
1097-0142journal_volume
55pub_type
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