Plasma ribonuclease: a marker for the detection of ovarian cancer.

Abstract:

:There were no significant differences between the mean blood plasma (leukocyte-free) RNAase activity among 128 healthy women volunteers age 13-70 and 49 women with benign gynecological tumors. Exceptions to this finding were three apparently healthy women volunteers who had plasma enzyme activity which was higher than two standard deviations from the mean of the control subjects. Increased plasma RNAase activity was also demonstrated for 21 of 22 patients with ovarian carcinomas of differential histological types. This group included two patients with Stage IA, two patients with Stage IC ovarian carcinoma, and 17 patients with advanced ovarian carcinoma. The one exception was a patient with a well encapsulated, mucinous cystadenocarcinoma, Stage IA. The plasma RNAase activity returned to normal values in all of the cancer patients who had no clinical evidence of residual malignant tissue after surgical treatment. However, the enzyme activity also returned to a normal value in one of the 17 women in whom all of the malignant tissue was not removed. These data indicate that plasma RNAase activity can be utilized as a tumor marker for the presence of ovarian malignancies of various histological types, and to differentiate between malignant and benign neoplasms.

journal_name

Cancer

journal_title

Cancer

authors

Sheid B,Lu T,Pedrinan L,Nelson JH Jr

doi

10.1002/1097-0142(197705)39:5<2204::aid-cncr282039

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

2204-8

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

39

pub_type

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