Abstract:
:There were no significant differences between the mean blood plasma (leukocyte-free) RNAase activity among 128 healthy women volunteers age 13-70 and 49 women with benign gynecological tumors. Exceptions to this finding were three apparently healthy women volunteers who had plasma enzyme activity which was higher than two standard deviations from the mean of the control subjects. Increased plasma RNAase activity was also demonstrated for 21 of 22 patients with ovarian carcinomas of differential histological types. This group included two patients with Stage IA, two patients with Stage IC ovarian carcinoma, and 17 patients with advanced ovarian carcinoma. The one exception was a patient with a well encapsulated, mucinous cystadenocarcinoma, Stage IA. The plasma RNAase activity returned to normal values in all of the cancer patients who had no clinical evidence of residual malignant tissue after surgical treatment. However, the enzyme activity also returned to a normal value in one of the 17 women in whom all of the malignant tissue was not removed. These data indicate that plasma RNAase activity can be utilized as a tumor marker for the presence of ovarian malignancies of various histological types, and to differentiate between malignant and benign neoplasms.
journal_name
Cancerjournal_title
Cancerauthors
Sheid B,Lu T,Pedrinan L,Nelson JH Jrdoi
10.1002/1097-0142(197705)39:5<2204::aid-cncr282039subject
Has Abstractpub_date
1977-05-01 00:00:00pages
2204-8issue
5eissn
0008-543Xissn
1097-0142journal_volume
39pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940815)74:4<1355::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract:BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26481
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Fulvestrant (ICI 182,780) is a new type of estrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. The authors report the prospectively planned combined analysis of data from 2 Phase III trials comparing fulvestrant 250 mg monthly (n=428) and anastrozole 1 mg daily (n=4...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.11468
更新日期:2003-07-15 00:00:00
abstract::In certain experimental tumor models, tumor growth is less pronounced in immune deficient animals. Characteristically, tumors such as the murine B16 melanoma and Lewis lung carcinoma (3LL) are weakly antigenic. We proposed that with such tumors that are weakly antigenic, growth is enhanced by T-cell factors. Young mic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1792::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract::The interferon (IFN) assay of the sera from the 40 patients with head and neck cancer was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. The patients mainly had Stage III or IV lesion without distant metastasis, and previously had not received ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841001)54:7<1239::aid-cncr2820
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Recent clinical studies have demonstrated that tumor angiogenesis is a potent prognostic indicator for breast cancer patients. The quantitation of endothelial growth factors is thought to be useful to assess angiogenic phenotype in the tumor. Among the many new endothelial growth factors, vascular endothelia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19960315)77:6<1101::aid-cn
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940415)73:8<2223::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract::The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197909)44:3<914::aid-cncr2820440
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:The response to antifungal therapy alone often is suboptimal in patients with cancer who have therapy-refractory neutropenia, and even donor-derived granulocyte transfusions (GTX) are not always successful. The authors evaluated the safety and efficacy of immune enhancement using recombinant interferon gamma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21929
更新日期:2006-06-15 00:00:00
abstract::The breast pathology files at the Institut Gustave-Russy in Villejuif, France, were searched for papillary cystadenomas and papillary carcinomas diagnosed between January 1, 1960, and December 31, 1974. A total of 158 cases were selected for this study; they were subclassified into 74 papillary cystadenomas, 63 papill...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810701)48:1<122::aid-cncr28204
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested an excess cancer risk in patients with carcinoid tumors. This association was reexamined using truly population-based data. METHODS:By means of data from the Danish Cancer Registry all carcinoid tumors diagnosed in Denmark between 1978 and 1989 were identified. All patients w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950701)76:1<106::aid-cncr28207
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The reliability of fine-needle aspiration cytology (FNAC) of breast masses in males could be compromised by lack of experience because breast carcinoma is rare in males and FNAC is not often used. In addition, FNAC of the more often encountered gynecomastia may lead to overdiagnosis. Therefore, in the curren...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10483
更新日期:2002-04-25 00:00:00
abstract:BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000101)88:1<169::aid-cnc
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS:An i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29041
更新日期:2015-01-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival. METHODS:A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24769
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. METHODS:A total of 199 patients with melanoma and non-small cell ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33196
更新日期:2020-12-15 00:00:00
abstract::The molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer. Identified abnormalities include both dominant-acting oncogenes (ras, myc, src) and suppressor genes which undergo inactivation or deletion (deleted in colorectal carcinoma gene [DCC], p53, adenomatous p...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920315)69:6+<1589::aid-cncr282
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow-up of patients with neurofibroma is limited. METHODS:The authors studied 4 cases of neurofibroma of the bladder diagnosed at Mayo Clinic from 1965 through 1990. Immunostains for ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract::Nickel-related cancers of the respiratory tract have been recognized for nearly 50 years and represent a unique opportunity for prevention among refinery workers. Studies of exposed employees have been conducted in which evaluations were made of the histopathologic changes in the respiratory mucosa and the body burden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800615)45:12<3061::aid-cncr282
更新日期:1980-06-15 00:00:00
abstract:BACKGROUND:Some patients with gastric carcinoma experience local disease recurrence despite undergoing curative resection of the tumor and regional lymph nodes (LNs), suggesting the presence of occult micrometastases. To evaluate the presence of gastric carcinoma micrometastasis in patients with otherwise histologicall...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2056::aid-cncr1545
更新日期:2001-10-15 00:00:00
abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31112
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The clinical dose of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro- sourea hydrochloride (ACNU) is limited by the bone marrow suppression it produces. The authors investigated whether bone marrow transplantation (BMT) associated with a high dose of ACNU could alleviate marrow toxicity ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930115)71:2<364::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract:BACKGROUND:Micropapillary serous carcinoma (MPSC), a recently described entity, is an ovarian tumor with a distinctive histologic architecture that lacks a destructive infiltrative growth pattern and behaves like a low-grade neoplasm. The purpose of this study was to determine if specific cytomorphologic features were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10619
更新日期:2002-06-25 00:00:00
abstract:BACKGROUND:Telomerase activity and telomere length have been shown to be involved in the control of cell proliferation and regulation of cell senescence. The expression of telomerase activity may endow cells with the capacity of unlimited proliferation and immortality. The authors examined the telomerase activity and t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001115)89:10<2092::aid-cncr9>3
更新日期:2000-11-15 00:00:00
abstract:BACKGROUND:The carboplatin-based chemotherapeutic regimen M-CAVI (methotrexate, carboplatin, and vinblastine) is active against bladder carcinoma and can be administered to patients who are ineligible to receive cisplatin or doxorubicin. The authors designed a randomized study to evaluate whether M-CAVI offers a therap...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19971115)80:10<1966::aid-c
更新日期:1997-11-15 00:00:00
abstract::The prolonged administration of bisphosphonates can reduce the frequency of morbid skeletal events in patients with metastatic breast carcinoma or multiple myeloma. The development of more potent bisphosphonates will simplify current therapeutic schemes and could improve the therapeutic effectiveness of bisphosphonate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1699::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Hispanics now represent a majority of residents in Miami-Dade County, Florida. In this report, the authors present new cancer incidence and mortality data for South Florida's Hispanic men for the period 1990-1998 and compare them with data from a previous report from the 1980s. Periodic updating of cancer in...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::A series of nine cases of radiation myelopathy seen at the University of California, San Francisco (UCSF) is reviewed, and their treatment data converted into nominal single doses (NSD) and equivalent single doses (ED). The 1% incidence level of myelopathy in the thoracic cord is 1015 rets (ED), and the 50% incidence...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197506)35:6<1558::aid-cncr282035
更新日期:1975-06-01 00:00:00
abstract::Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1180::aid-cncr2820
更新日期:1990-03-01 00:00:00