Quantitative analysis of vascular endothelial growth factor in primary breast cancer.

Abstract:

BACKGROUND:Recent clinical studies have demonstrated that tumor angiogenesis is a potent prognostic indicator for breast cancer patients. The quantitation of endothelial growth factors is thought to be useful to assess angiogenic phenotype in the tumor. Among the many new endothelial growth factors, vascular endothelial growth factor (VEGF) is known to be particularly responsible for promoting the neovascularization in human breast cancer. METHODS:Intratumoral protein levels of VEGF were measured by enzymatic immunoassay in 135 primary breast cancer tissues. The VEGF levels were compared with the microvessel density evaluated by immunostaining the endothelial antigen and also were compared with intratumoral protein levels of other endothelial growth factors, including basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF). RESULTS:Intratumoral VEGF concentrations varied from 3.3 pg/mg protein to 2032 pg/mg protein (average 148 pg/mg protein). An immunocytochemical analysis using anti-VEGF antibody confirmed that VEGF was located mainly in the cytoplasm of the tumor cells. The VEGF concentrations were significantly higher in vascularly rich tumors than in vascularly poor tumors. No significant association was found between VEGF concentrations and the two other endothelial growth factor concentrations. CONCLUSIONS:The quantitation of intratumoral VFGF levels seems to be useful for assessing the activity of tumor angiogenesis.

journal_name

Cancer

journal_title

Cancer

authors

Toi M,Kondo S,Suzuki H,Yamamoto Y,Inada K,Imazawa T,Taniguchi T,Tominaga T

doi

10.1002/(sici)1097-0142(19960315)77:6<1101::aid-cn

subject

Has Abstract

pub_date

1996-03-15 00:00:00

pages

1101-6

issue

6

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19960315)77:6<1101::AID-CN

journal_volume

77

pub_type

杂志文章

相关文献

CANCER文献大全
  • Mitomycin in metastatic breast cancer refractory to hormonal and combination chemotherapy.

    abstract::Forty-three patients with evaluable metastatic breast cancer refractory to hormonal agents and extensive combination chemotherapy including doxorubicin were treated with mitomycin, 20 mg/m2 intravenously every 6 weeks. There were five partial responses (12%) and three minor responses (7%), with a mean time to progress...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851115)56:10<2381::aid-cncr282

    authors: Pasterz RB,Buzdar AU,Hortobagyi GN,Blumenschein GR

    更新日期:1985-11-15 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00

  • Racial differences in cervical cancer survival in the Detroit metropolitan area.

    abstract:BACKGROUND:African-American (AA) women have lower survival rates from cervical cancer compared with white women. The objective of this study was to examine the influence of socioeconomic status (SES) and other variables on racial disparities in overall survival among women with invasive cervical cancer. METHODS:One th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23310

    authors: Movva S,Noone AM,Banerjee M,Patel DA,Schwartz K,Yee CL,Simon MS

    更新日期:2008-03-15 00:00:00

  • Effect of the potent aromatase inhibitor fadrozole hydrochloride (CGS 16949A) in postmenopausal women with breast carcinoma.

    abstract:BACKGROUND:Fadrozole hydrochloride (CGS 16949A) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. Circulating estradiol, estrone, and estrone sulfate are reduc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990101)85:1<100::aid-cnc

    authors: Costa LA,Kopreski MS,Demers LM,Chinchilli VM,Santen RJ,Harvey HA,Lipton A

    更新日期:1999-01-01 00:00:00

  • Comparison of 5-fluorouracil with 5-fluorouracil, cyclophosphamide, and methotrexate in metastatic colorectal carcinoma.

    abstract::Thirty-eight patients with metastatic colorecal carcinoma were treated with 5-fluorouracil (5-FU), and 38 patients were treated with the combination of 5-FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the two regimens. Comb...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197511)36:5<1589::aid-cncr282036

    authors: Richards F 2nd,Pajak TL,Cooper MR,Spurr CL

    更新日期:1975-11-01 00:00:00

  • Clinicopathologic features of patients with hepatocellular carcinoma surviving >10 years after hepatic resection.

    abstract:BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Shirabe K,Shimada M,Kajiyama K,Gion T,Ikeda Y,Hasegawa H,Taguchi K,Takenaka K,Sugimachi K

    更新日期:1998-12-01 00:00:00

  • Adrenal adenomas and adrenal carcinomas in association with hereditary adenomatosis of the colon and rectum.

    abstract::Hereditary adenomatosis of the colon and rectum (HACR) is associated with a wide variety of extracolonic manifestations. Two cases of neoplasia involving the adrenal gland are reported, one adenoma and one carcinoma. The literature relating these lesions to HACR and other syndromes of malignant and nonmalignant growth...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9<2001::aid-cncr2820

    authors: Painter TA,Jagelman DG

    更新日期:1985-05-01 00:00:00

  • Assessing the potential cost-effectiveness of retesting IHC0, IHC1+, or FISH-negative early stage breast cancer patients for HER2 status.

    abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28196

    authors: Garrison LP Jr,Lalla D,Brammer M,Babigumira JB,Wang B,Perez EA

    更新日期:2013-09-01 00:00:00

  • DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma.

    abstract:BACKGROUND:The objective of this study was to investigate whether polymorphisms in DNA repair genes affect clinical outcome of never-smokers with lung adenocarcinoma (NSLA). METHOD:Common polymorphisms in the DNA repair genes ribonucleotide reductase M1 (RRM1), excision repair cross-complementation group 1 (ERCC1), an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25863

    authors: Han JY,Yoon KA,Park JH,Lee YJ,Lee GK,Han JH,Yoon SJ,Yun T,Kim HT,Lee JS

    更新日期:2011-07-15 00:00:00

  • A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer.

    abstract:BACKGROUND:Patients scheduled to receive chemotherapy frequently undergo pretherapy dental treatment to eliminate potential sources of odontogenic infection. A prospective study was conducted to assess a new protocol emphasizing minimal pretherapy dental treatment. METHODS:Forty-eight consecutive patients diagnosed wi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Toljanic JA,Bedard JF,Larson RA,Fox JP

    更新日期:1999-04-15 00:00:00

  • Serum parathyroid hormone-related peptide is associated with systemic inflammation and adverse prognosis in gastroesophageal carcinoma.

    abstract:BACKGROUND:Parathyroid hormone-related peptide (PTHrP) is a tumor-derived circulating factor that has been associated with hypercalcemia of malignancy. The role of PTHrP as a prognostic indicator remains unclear. Studies suggest that it may function as a growth factor; and, recently, the ability of PTHrP to induce cyto...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20972

    authors: Deans C,Wigmore S,Paterson-Brown S,Black J,Ross J,Fearon KC

    更新日期:2005-05-01 00:00:00

  • Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH).

    abstract:BACKGROUND:Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Socie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21836

    authors: Furtwaengler R,Reinhard H,Leuschner I,Schenk JP,Goebel U,Claviez A,Kulozik A,Zoubek A,von Schweinitz D,Graf N,Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH) Nephroblastoma Study Group.

    更新日期:2006-05-15 00:00:00

  • Acinic cell adenocarcinoma of minor salivary glands.

    abstract::Nine cases identified as acinic cell adenocarcinoma of minor salivary glands from the files of the Armed Forces Institute of Pathology and the Department of Pathology, Temple University School of Dentistry were studied to determine the clinical and histomorphologic parameters of this lesion. One case was examined ultr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197808)42:2<678::aid-cncr2820420

    authors: Chen SY,Brannon RB,Miller AS,White DK,Hooker SP

    更新日期:1978-08-01 00:00:00

  • Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness.

    abstract:BACKGROUND:Prognostic markers for renal cell carcinoma (RCC), such as patient symptoms, tumor stage, tumor size, and tumor grade, are useful for determining appropriate follow-up and selecting patients for adjuvant therapy. Histologic coagulative tumor necrosis, also reported to be a prognostic marker for RCC, has not ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21206

    authors: Sengupta S,Lohse CM,Leibovich BC,Frank I,Thompson RH,Webster WS,Zincke H,Blute ML,Cheville JC,Kwon ED

    更新日期:2005-08-01 00:00:00

  • Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

    abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820

    authors: Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JC

    更新日期:1992-05-01 00:00:00

  • Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy.

    abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Turner BC,Gumbs AA,Carbone CJ,Carter D,Glazer PM,Haffty BG

    更新日期:2000-03-01 00:00:00

  • Neurotoxicity of bortezomib therapy in multiple myeloma: a single-center experience and review of the literature.

    abstract:BACKGROUND:Bortezomib is active in heavily pretreated multiple myeloma patients; the dose-limiting toxicity is peripheral neuropathy (PN). METHODS:The authors retrospectively reviewed the incidence, severity, and risk factors for PN in 78 patients who received bortezomib. The median age was 57 years (range, 33-80 year...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/cncr.22921

    authors: Badros A,Goloubeva O,Dalal JS,Can I,Thompson J,Rapoport AP,Heyman M,Akpek G,Fenton RG

    更新日期:2007-09-01 00:00:00

  • A correlation of argyrophilic nucleolar organizer regions with stages of hepatocellular carcinoma.

    abstract:BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930101)71:1<44::aid-cncr282071

    authors: Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

    更新日期:1993-01-01 00:00:00

  • Impact of the human papillomavirus status on the development of high-grade cervical intraepithelial neoplasia in women negative for intraepithelial lesions or malignancy at the baseline: A 9-year Swedish nested case-control follow-up study.

    abstract:BACKGROUND:The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31788

    authors: Fröberg M,Östensson E,Belkić K,Oštrbenk A,Poljak M,Mints M,Arbyn M,Andersson S

    更新日期:2019-01-15 00:00:00

  • Polymerase chain reaction-based restriction fragment length polymorphism analysis of the short arm of chromosome 3 in primary head and neck squamous carcinoma.

    abstract:BACKGROUND:Deletion or loss of heterozygosity (LOH) at the polymorphic loci on the short arm of chromosome 3 has been reported in a large number of renal cell, small cell lung, non-small cell lung, and cervical carcinomas, suggesting the presence of one or more putative tumor suppressor genes at chromosome 3p. Similar ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930801)72:3<881::aid-cncr28207

    authors: el-Naggar AK,Lee MS,Wang G,Luna MA,Goepfert H,Batsakis JG

    更新日期:1993-08-01 00:00:00

  • In sickness and in health: transition of cancer-related care for older adolescents and young adults.

    abstract::With nearly 80% of childhood cancer patients achieving cure, there are more adult survivors living now than at any other time in history. Because they are at risk for developing complications of treatment years later, it is recommended that survivors undergo systematic, regular monitoring into young adulthood and beyo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22109

    authors: Freyer DR,Kibrick-Lazear R

    更新日期:2006-10-01 00:00:00

  • Histogenesis of spontaneous regression of cervical intraepithelial neoplasias.

    abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040

    authors: Bajardi F

    更新日期:1984-08-15 00:00:00

  • The natural five-year course in bronchial carcinoma. Epidemiologic results.

    abstract::A series of 273 unselected patients with bronchial carcinoma, comprising a total prospective 5-year study from a Swedish county with an observed 5-year survival of 7.0%, is presented. The autopsy rate in deceased patients was 94%. All diagnoses were histologically or cytologically verified. The 5-year survival rates f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840515)53:10<2211::aid-cncr282

    authors: Nõu E

    更新日期:1984-05-15 00:00:00

  • Chemotherapy in patients with recurrent and progressive central neurocytoma.

    abstract:BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000101)88:1<169::aid-cnc

    authors: Brandes AA,Amistà P,Gardiman M,Volpin L,Danieli D,Guglielmi B,Carollo C,Pinna G,Turazzi S,Monfardini S

    更新日期:2000-01-01 00:00:00

  • Racial and Ethnic Disparities in Travel for Head and Neck Cancer Treatment and the Impact of Travel Distance on Survival.

    abstract:BACKGROUND:Patients who travel a long distance (≥50 miles) for cancer care have improved outcomes. However, to the authors' knowledge, the prevalence of long travel distances for treatment by patients with head and neck squamous cell carcinoma (HNSCC), and the effect of travel distance on overall survival (OS), remains...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31571

    authors: Graboyes EM,Ellis MA,Li H,Kaczmar JM,Sharma AK,Lentsch EJ,Day TA,Hughes Halbert C

    更新日期:2018-08-01 00:00:00

  • Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma.

    abstract:BACKGROUND:The authors established the genotype frequencies of cytochrome P450 (CYP1A1/MspI, CYP2E1/PstI, and CYP2E1/DraI), glutathione-S-transferase (GSTM1 and GSTT1), and p53 (exon 4/AcclI and intron 3/16-base pair duplication) gene polymorphisms in cervical carcinoma patients and controls and evaluated the associati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000501)88:9<2082::aid-cn

    authors: Kim JW,Lee CG,Park YG,Kim KS,Kim IK,Sohn YW,Min HK,Lee JM,Namkoong SE

    更新日期:2000-05-01 00:00:00

  • Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma.

    abstract:BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24922

    authors: Spina M,Chimienti E,Martellotta F,Vaccher E,Berretta M,Zanet E,Lleshi A,Canzonieri V,Bulian P,Tirelli U

    更新日期:2010-03-15 00:00:00

  • Lymphoma of the spinal extradural space.

    abstract::Ninety-four patients with lymphoma involving the extradural space with spinal cord compression proven at the time of laminectomy were reviewed. There were about three times as many patients with non-Hodgkin's lymphoma than with Hodgkin's disease. The majority of those with Hodgkin's disease had a proven histologic dia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197610)38:4<1862::aid-cncr282038

    authors: Haddad P,Thaell JF,Kiely JM,Harrison EG,Miller RH

    更新日期:1976-10-01 00:00:00

  • Carcinoma of the pancreas: review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy.

    abstract::A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197603)37:3<1519::aid-cncr282037

    authors: Tepper J,Nardi G,Sutt H

    更新日期:1976-03-01 00:00:00

  • The DNA content of human plasma cells.

    abstract::The DNA content of human plasma cells from myeloma patients relative to that of leukocytes was determined by flow and microscopic cytofluorometry after propidium iodide and fluorescent Feulgen staining, respectively. Mononucleated myeloma plasma cells from all of the 17 patients studied contained more DNA (17 to 58%) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810515)47:10<2433::aid-cncr282

    authors: Brox L,Mowles D,Pollock B,Belch A

    更新日期:1981-05-15 00:00:00