Effects of high-dose chemotherapy with syngeneic bone marrow transplantation in experimental brain tumor in rats.

Abstract:

BACKGROUND:The clinical dose of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro- sourea hydrochloride (ACNU) is limited by the bone marrow suppression it produces. The authors investigated whether bone marrow transplantation (BMT) associated with a high dose of ACNU could alleviate marrow toxicity and achieve greater antitumor effects in Fischer rats. METHODS AND RESULTS:High doses of ACNU (20, 25, and 30 mg/kg) were administered on day 1, followed by injection of syngeneic bone marrow cells on day 3. Patterns of leukocyte recovery were compared in BMT and non-BMT groups. There was a significant benefit in leukocyte recovery in the BMT groups. A 9L glioma that was sensitive to ACNU was transplanted into the brain tissue of rats. Seven days later, the animals were divided into three groups based on the dose of ACNU (2, 10, and 25 mg/kg). The median survival time increased with larger ACNU doses. CONCLUSIONS:This suggested that high-dose ACNU chemotherapy with BMT could achieve greater antitumor effects and less bone marrow suppression than high-dose ACNU alone.

journal_name

Cancer

journal_title

Cancer

authors

Soma M,Shoin K,Yamashita J

doi

10.1002/1097-0142(19930115)71:2<364::aid-cncr28207

subject

Has Abstract

pub_date

1993-01-15 00:00:00

pages

364-9

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

71

pub_type

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