Radiotherapy results for nodular sclerosing Hodgkin's disease after clinical staging.

abstract：BACKGROUND:Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in p...

journal_title：Cancer

authors： Zhao C,Yasui K,Lee CJ,Kurioka H,Hosokawa Y,Oka T,Inazawa J

更新日期：2003-07-01 00:00:00

abstract：:The records of 98 children with suprasellar tumors treated between 1950 and 1975, at Columbia-Presbyterian Medical Center, were reviewed. Most of the children with germ cell tumors or posterior chiasmal gliomas irradiated with 5000 rad in six weeks using extended field, children with craniopharyngiomas treated with to...

journal_title：Cancer

authors： Sung DI

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Tyrosine kinases, such as c-KIT, c-ABL, and platelet-derived growth factor-beta (PDGFR-beta), are important regulators of cell growth. Highly potent and selective inhibitors of tyrosine kinases are being investigated as alternatives to standard chemotherapy. One such inhibitor, imatinib mesylate, is being us...

journal_title：Cancer

authors： Schmandt RE,Broaddus R,Lu KH,Shvartsman H,Thornton A,Malpica A,Sun C,Bodurka DC,Gershenson DM

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:Recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) is associated with poor survival. Platinum-based chemotherapy is often a first-line treatment. Pemetrexed has shown single-agent activity in SCCHN and in combination with cisplatin for other tumors. This trial examined the efficacy ...

journal_title：Cancer

authors： Urba S,van Herpen CM,Sahoo TP,Shin DM,Licitra L,Mezei K,Reuter C,Hitt R,Russo F,Chang SC,Hossain AM,Frimodt-Moller B,Koustenis A,Hong RL

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain. Patients at the authors' institution routinely are switched from transdermal to intravenous (IV) fentanyl using a 1:1 (transdermal:IV) conversion during severe episodes of pain. ...

journal_title：Cancer

authors： Kornick CA,Santiago-Palma J,Schulman G,O'Brien PC,Weigand S,Payne R,Manfredi PL

更新日期：2003-06-15 00:00:00

abstract：:External-beam irradiation of prostatic cancer was introduced at Stanford in 1956. The program has sought to determine the following: whether prostatic carcinoma can be cured by external beam radiation therapy, with what frequency this can be accomplished, which patients are best suited for irradiation, and what techni...

journal_title：Cancer

authors： Bagshaw MA,Ray GR,Cox RS

更新日期：1987-08-01 00:00:00

abstract：:One hundred eighty-nine patients received a four-drug combination consisting of cyclophosphamide, Oncovin (vincristine), methyl CCNU, and bleomycin (COMB), according to three different drug regimens, performed sequentially. Of the 189, 62 had a partial response (33%) including 11/33 with squamous lung cancer, 11/32 wi...

journal_title：Cancer

authors： Livingston RB,Einhorn LH,Bodey GP,Burgess MA,Freireich EJ,Gottlieb JA

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Cisplatin, 5-flourouracil (5-FU), and leucovorin (PFL) chemotherapy has been reported to be effective in the treatment of cancers but severe mucositis or neutropenia are dose limiting toxicities. This Phase II study evaluated the anticancer effect and the toxicities of a new weekly 24-hour infusional PFL che...

journal_title：Cancer

authors： Chi KH,Chan WK,Shu CH,Law CK,Chen SY,Yen SH,Chen KY

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...

journal_title：Cancer

authors： Manolitsas TP,Wain GV,Williams KE,Freidlander M,Hacker NF

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:The activation of the clotting-fibrinolytic system in cancer patients is common and represents an unfavorable clinical sign. D-dimer (DD) is a sensitive marker of fibrinolysis. METHODS:The current study comprised 826 new lung carcinoma patients seen consecutively in a single institution over a 10-year perio...

journal_title：Cancer

authors： Buccheri G,Torchio P,Ferrigno D

更新日期：2003-06-15 00:00:00

abstract：:A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologi...

journal_title：Cancer

authors： Kamesaki H,Koya M,Miwa H,Kita K,Doi S,Tatsumi E,Hatanaka M,Uchino H

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine t...

journal_title：Cancer

authors： O'Reilly EM,Lee JW,Lowery MA,Capanu M,Stadler ZK,Moore MJ,Dhani N,Kindler HL,Estrella H,Maynard H,Golan T,Segal A,Salo-Mullen EE,Yu KH,Epstein AS,Segal M,Brenner R,Do RK,Chen AP,Tang LH,Kelsen DP

更新日期：2018-04-01 00:00:00

abstract：:Thrombocytosis above 40.0 X 10(4)/mm3 occurred in five of six (83%) patients with malignant mesothelioma. In contrast, the incidence of thrombocytosis was 7.5% in patients with lung adenocarcinoma, 12.5% in squamous cell carcinoma, 5.1% in small cell carcinoma, and 41.7% in large cell carcinoma, respectively. The plat...

journal_title：Cancer

authors： Nakano T,Fujii J,Tamura S,Hada T,Higashino K

更新日期：1986-10-15 00:00:00

abstract：BACKGROUND:Gene expression profiling should be applicable to needle biopsy samples if microarray technology is to become practically useful for clinical research or management of breast carcinoma. This study compared gene expression profiles derived from fine-needle aspiration biopsy (FNAB) and from core needle biopsy ...

journal_title：Cancer

authors： Symmans WF,Ayers M,Clark EA,Stec J,Hess KR,Sneige N,Buchholz TA,Krishnamurthy S,Ibrahim NK,Buzdar AU,Theriault RL,Rosales MF,Thomas ES,Gwyn KM,Green MC,Syed AR,Hortobagyi GN,Pusztai L

更新日期：2003-06-15 00:00:00

abstract：BACKGROUND:Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling-based risk and delTP53 status, whose collective impact has not been examined in the context of specific therapies. METHODS:The authors examined...

journal_title：Cancer

authors： Waheed S,Shaughnessy JD,van Rhee F,Alsayed Y,Nair B,Anaissie E,Szymonifka J,Hoering A,Crowley J,Barlogie B

更新日期：2011-03-01 00:00:00

abstract：:Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after thre...

journal_title：Cancer

authors： Mutch DG,Soper JT,Babcock CJ,Clarke-Pearson DL,Hammond CB

更新日期：1990-09-01 00:00:00

abstract：:Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cis-diamminedichloro platinum II in a Phase I-II trial. A safe starting dose of 120 mg/m2 was established. An overall response rate of 45% was noted with significant responses observed among patients with melanoma, sarco...

journal_title：Cancer

authors： Calvo DB 3rd,Patt YZ,Wallace S,Chuang VP,Benjamin RS,Pritchard JD,Hersh EM,Bodey GP Sr,Mavligit GM

更新日期：1980-03-15 00:00:00

abstract：BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...

journal_title：Cancer

authors： Thomas RM,Baybick JH,Elsayed AM,Sobin LH

更新日期：1994-04-15 00:00:00

abstract：BACKGROUND:Melanoma vaccine treatment appears to slow the progression of melanoma in some patients, particularly in patients in whom it stimulates cellular antimelanoma immune responses. The relationship of vaccine-induced antibody responses to clinical outcome is less clear. The purpose of this study was to investigat...

journal_title：Cancer

authors： Miller K,Abeles G,Oratz R,Zeleniuch-Jacquotte A,Cui J,Roses DF,Harris MN,Bystryn JC

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:The role of myeloablative chemotherapy in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors (MB/ST-PNET) is controversial, in particular in patients who develop recurrent disease after craniospinal radiotherapy. METHODS:In this retrospective analysis, the authors in...

journal_title：Cancer

authors： Butturini AM,Jacob M,Aguajo J,Vander-Walde NA,Villablanca J,Jubran R,Erdreich-Epstein A,Marachelian A,Dhall G,Finlay JL

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Investigations regarding the impact of tumor biology after surgical management of colorectal liver metastasis have focused largely on overall survival. We investigated the impact of codon-specific KRAS mutations on the rates and patterns of recurrence in patients after surgery for colorectal liver metastasis...

journal_title：Cancer

authors： Margonis GA,Kim Y,Sasaki K,Samaha M,Amini N,Pawlik TM

更新日期：2016-09-01 00:00:00

abstract：:If women examine their breasts thoroughly and regularly they may promptly recognize abnormal tissue changes. The level of skill and motivation required for effective breast self-examination (BSE), however, is very high. In a prospective study of 304 patients with newly diagnosed breast cancer, 165 (54%) claimed to pra...

journal_title：Cancer

authors： Philip J,Harris WG,Flaherty C,Joslin CA

更新日期：1986-08-15 00:00:00

abstract：:Turcot's syndrome is a rare, genetically transmittable disease in which patients with colonic polyposis (possibly complicated by the progression to adenocarcinoma) have malignant central nervous system neoplasms. Dominant, recessive, and sporadic cases have been described. A 26-year-old man is reported with no relevan...

journal_title：Cancer

authors： Newton HB,Rosenblum MK,Malkin MG

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...

journal_title：Cancer

authors： Andreola S,Leo E,Belli F,Bufalino R,Tomasic G,Lavarino C,Baldini MT,Meroni E

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...

journal_title：Cancer

authors： Gamelin EC,Danquechin-Dorval EM,Dumesnil YF,Maillart PJ,Goudier MJ,Burtin PC,Delva RG,Lortholary AH,Gesta PH,Larra FG

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:The authors assessed the prognostic significance of abnormal cyclin dependent kinase inhibitor (CDKI) expression in adenocarcinomas of the uterine cervix. METHODS:Population-based, archival material from patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I and II cervical adeno...

journal_title：Cancer

authors： Alfsen GC,Reed W,Sandstad B,Kristensen GB,Abeler VM

更新日期：2003-11-01 00:00:00

abstract：:The hepatic histopathology was studied in 125 patients with Hodgkin's disease to determine whether there are any features other than Reed-Sternberg (RS) cells that might aid in the diagnosis of hepatic involvement by the neoplastic process. Liver biopsy specimens from 41 patients with Hodgkin's disease in the liver we...

journal_title：Cancer

authors： Dich NH,Goodman ZD,Klein MA

更新日期：1989-11-15 00:00:00

abstract：:Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

journal_title：Cancer

authors： Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

更新日期：1985-06-15 00:00:00

abstract：BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...

journal_title：Cancer

authors： Jim MA,Pinheiro PS,Carreira H,Espey DK,Wiggins CL,Weir HK

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Granular cell tumors (GCTs) are uncommon tumors of putative schwannian derivation that are rarely malignant. Although recent studies have addressed a histologic correlation with malignant behavior, similar studies have not been done on cytologic material. METHODS:The authors evaluated 3 malignant GCTs and 1...

journal_title：Cancer

authors： Wieczorek TJ,Krane JF,Domanski HA,Akerman M,Carlén B,Misdraji J,Granter SR

更新日期：2001-12-25 00:00:00