COMB (cyclophosphamide, oncovin, methyl-CCNU, and bleomycin): a four-drug combination in solid tumors.

abstract：BACKGROUND:Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study of a stable liposomal doxor...

journal_title：Cancer

authors： Hong RL,Tseng YL

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross-sectional study of the long-term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon. METHODS:Seven hundred thirty-nine patients who were treat...

journal_title：Cancer

authors： Glendenning JL,Barbachano Y,Norman AR,Dearnaley DP,Horwich A,Huddart RA

更新日期：2010-05-15 00:00:00

abstract：:Improvement in the management of acute leukemia in adults has not progressed nearly so rapidly as has the treatment of childhood leukemia. One important difference is that most adults have myeloblastic or related forms of the disease (AML), whereas the majority of children have lymphoblastic leukemia (ALL). However, e...

journal_title：Cancer

authors： Clarkson BD,Dowling MD,Gee TS,Cunningham IB,Burchenal JH

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:The effect on prognosis of adding imatinib mesylate to the treatment of patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) has not been explored fully. The objective of the current study was to evaluate the benefit of adding imatinib to the treatment sequence of patients w...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Cortes J,Shan J,Giles F,Garcia-Manero G,Verstovsek S,Faderl S,Rios MB,Talpaz M

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Neovascularization reportedly is correlated with metastasis, recurrence, and prognosis in some types of tumors. Microvessel quantification in so-called "hot spots" has been studied extensively as the only factor reflecting angiogenesis in various malignant tumors. The objective of this report was to evaluate...

journal_title：Cancer

authors： Pavlopoulos PM,Konstantinidou AE,Agapitos E,Kavantzas N,Nikolopoulou P,Davaris P

更新日期：1998-11-15 00:00:00

abstract：:Four cell lines were derived from childhood malignancies: rhabdomyosarcoma, sarcoma, lymphosarcoma and an American Burkitt's lymphoma. Cells of the four lines formed tumors in immunosuppressed newborn hamsters. The tumors had a microscopic appearance like that of the tumors from which the cell lines were derived. No ...

journal_title：Cancer

authors： McAllister RM,Nelson-Rees WA,Peer M,Laug WE,Isaacs H Jr,Gilden RV,Rongey RW,Gardner MB

更新日期：1975-11-01 00:00:00

abstract：:This article documents the study of 383 cases of lung cancer in uranium miners and presents for the first time the relationship of radioactive radon gas and cigarette smoking. There is evidence that alpha radiation from radon gas at exposure levels above 465 working level months (WLM) is a strong contributor to the de...

journal_title：Cancer

authors： Saccomanno G,Huth GC,Auerbach O,Kuschner M

更新日期：1988-10-01 00:00:00

abstract：:The reported results from throughout the world of modern treatment of testicular seminoma are reviewed for the various clinical stages of disease. The three-year survival rate for 1,346 patients with Stage 1 and 2 disease is 91%. Since the review reveals considerable differences in staging methods, a clinically useful...

journal_title：Cancer

authors： Caldwell WL,Kademian MT,Frias Z,Davis TE

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:The uptake of thallium-201 (T1-201) in malignant tumors is associated with malignant potential (metastatic potential and proliferative activity). The grade of accumulation of T1-201 in malignant tumors may provide information regarding prognosis. METHODS:A T1-201 single photon emission computed tomography w...

journal_title：Cancer

authors： Takekawa H,Takaoka K,Tsukamoto E,Kanegae K,Miller F,Kawakami Y

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Obesity is a well known risk factor for the development of endometrial cancer; however, weight alone does not account for all cases. The authors hypothesized that insulin resistance also contributes to an increased risk for endometrial cancer. Adiponectin is a protein secreted by adipose cells and has been s...

journal_title：Cancer

authors： Soliman PT,Wu D,Tortolero-Luna G,Schmeler KM,Slomovitz BM,Bray MS,Gershenson DM,Lu KH

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

journal_title：Cancer

authors： Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Knowledge of the expression of the galectins in human colon carcinomas is mainly restricted to galectin-3 and, to a lesser extent, galectin-1. The current study analyzed the prognostic values contributed by galectin-1, galectin-3, galectin-4, and galectin-8 in cases of colon carcinoma. METHODS:The authors s...

journal_title：Cancer

authors： Nagy N,Legendre H,Engels O,André S,Kaltner H,Wasano K,Zick Y,Pector JC,Decaestecker C,Gabius HJ,Salmon I,Kiss R

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Whereas the role of specific symptoms, such as pain and fatigue, for quality of life (QOL) is unquestioned, their relative importance for long-lasting impairments in QOL in cancer patients has rarely been assessed quantitatively. The authors, therefore, aimed to identify symptoms most predictive of limitatio...

journal_title：Cancer

authors： Arndt V,Stegmaier C,Ziegler H,Brenner H

更新日期：2006-11-15 00:00:00

abstract：:Review of the consultation records of the Gastrointestinal Surgical Oncology service at Roswell Park Memorial Institute from 1982 to 1987 revealed 22 patients with a clinical diagnosis of neutropenic enterocolitis. Ninety-one percent of the patients had hematologic malignancies, and 95% were receiving cytotoxic chemot...

journal_title：Cancer

authors： Wade DS,Nava HR,Douglass HO Jr

更新日期：1992-01-01 00:00:00

abstract：:Only three previous reports on the ultrastructural appearance of tibial adamantinoma have been found among some 120 cases of this tumor reported in the literature. The tumor in our case is less differentiated than the cases previously reported. We believe it is of epithelial character and the possibilities of its hist...

journal_title：Cancer

authors： Yoneyama T,Winter WG,Milsow L

更新日期：1977-09-01 00:00:00

abstract：:Sixty-three gastrectomy specimens (21 with early intestinal type carcinoma, 21 with early diffuse carcinoma, and 21 with benign nonneoplastic lesions) were examined histochemically to determine the distribution of intestinal metaplasia (IM), particularly the sulphomucin-secreting type (Type IIB IM). The frequency and ...

journal_title：Cancer

authors： Matsukuma A,Mori M,Enjoji M

更新日期：1990-08-15 00:00:00

abstract：:The responses of 23 patients with agnogenic myeloid metaplasia (AMM) to androgen therapy were studied. Various clinical and laboratory parameters were analyzed for their value in determining response to therapy and length of survival. Fifty-seven percent of patients responded, as determined by a sustained increase in ...

journal_title：Cancer

authors： Besa EC,Nowell PC,Geller NL,Gardner FH

更新日期：1982-01-15 00:00:00

abstract：BACKGROUND:Health systems in Sub-Saharan Africa are not prepared for the rapid rise in cancer rates projected in the region over the next decades. More must be understood about the current state of cancer care in this region to target improvement efforts. Yaounde General Hospital (YGH) currently is the only site in Cam...

journal_title：Cancer

authors： Price AJ,Ndom P,Atenguena E,Mambou Nouemssi JP,Ryder RW

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. METHODS:The cancer cell dissociation...

journal_title：Cancer

authors： Kurizaki T,Egami H,Hirota M,Akagi J,Ohmachi H,Yamamoto S,Ogawa M

更新日期：1995-03-15 00:00:00

abstract：:Primary adenocarcinoma of the duodenum is rare. An extensive experience with fiberoptic esophagogastro-duodenoscopy in our institution has indicated that duodenal neoplasms may be more frequent than suspected and are readily diagnosed by this modality. With this mind, clinical, pathological, diagnostic and therapeutic...

journal_title：Cancer

authors： Spira IA,Ghazi A,Wolff WI

更新日期：1977-04-01 00:00:00

abstract：:A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a fe...

journal_title：Cancer

authors： Tamai S,Kameya T,Shimosato Y,Tsumuraya M,Wada T

更新日期：1980-09-15 00:00:00

abstract：BACKGROUND:The authors developed fluoroscopic real-time tumor-tracking radiation therapy (RTRT) by insertion of a gold marker using bronchofiberscopy to reduce uncertainties in organ motion and set-up error in external radiotherapy for moving tumors. The purpose of the current study was to evaluate RTRT's feasibility i...

journal_title：Cancer

authors： Harada T,Shirato H,Ogura S,Oizumi S,Yamazaki K,Shimizu S,Onimaru R,Miyasaka K,Nishimura M,Dosaka-Akita H

更新日期：2002-10-15 00:00:00

abstract：:The fine structure of a pineal germinoma was studied in tissue blocks and in tissue culture. The original tumor contained large primary tumor cells, lymphocytes, macrophages, plasma cells, and astrocytes. The large primary tumor cells were characterized by large nuclei, relatively scanty organelles, abundant glycogen,...

journal_title：Cancer

authors： Markesbery WR,Brooks WH,Milsow L,Mortara RH

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...

journal_title：Cancer

authors： Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate prevalence and risk factors for emotional and behavioral problems in dependent children of cancer patients using a multinational research design. METHODS:The sample comprised 350 ill parents, 250 healthy partners, and 352 children. Parents assessed the child's psychological func...

journal_title：Cancer

authors： Thastum M,Watson M,Kienbacher C,Piha J,Steck B,Zachariae R,Baldus C,Romer G

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Optic pathway gliomas (OPGs) are commonly noted in pediatric oncology services. Radiotherapy is effective at controlling tumors, but has many undesirable late effects, especially in patients with neurofibromatosis. Chemotherapy is commonly used to preserve vision and delay or eliminate the need for radiother...

journal_title：Cancer

authors： Dodgshun AJ,Elder JE,Hansford JR,Sullivan MJ

更新日期：2015-12-01 00:00:00

abstract：:Renal cell carcinoma (RCC) has remained refractory to substantive change of its natural history despite intervention with a number of therapeutic modalities. Alpha interferons leukocyte interferon alpha [HuIFN-alpha (Le)] and lymphoblastoid interferon alpha [HuIFN-alpha (Ly)] initially were shown to produce regression...

journal_title：Cancer

authors： Neidhart JA

更新日期：1986-04-15 00:00:00

abstract：BACKGROUND:Hepatocyte growth factor receptor (c-met), autocrine motility factor receptor (AMFR), and urokinase-type plasminogen activator receptor (uPAR) are known to play important roles in tumor cell migration, invasion, and metastasis. The authors studied the relation between the expression patterns of these genes a...

journal_title：Cancer

authors： Taniguchi K,Yonemura Y,Nojima N,Hirono Y,Fushida S,Fujimura T,Miwa K,Endo Y,Yamamoto H,Watanabe H

更新日期：1998-06-01 00:00:00

abstract：:Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...

journal_title：Cancer

authors： Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

更新日期：1987-11-15 00:00:00

abstract：:Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

journal_title：Cancer

authors： Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

更新日期：1985-06-15 00:00:00