Relationship of radioactive radon daughters and cigarette smoking in the genesis of lung cancer in uranium miners.

Abstract:

:This article documents the study of 383 cases of lung cancer in uranium miners and presents for the first time the relationship of radioactive radon gas and cigarette smoking. There is evidence that alpha radiation from radon gas at exposure levels above 465 working level months (WLM) is a strong contributor to the development of lung cancer. Cigarette smoking plays the most significant role in causing lung tumor; this is also noticed in nonminers who smoke cigarettes. A synergistic or additive effect of these two carcinogens is strongly suggested. The data indicate that small cell tumors develop in younger nonsmoking miners exposed to radon levels above 465 WLM. Lung cancers develop in smoking miners at lower levels of radon exposure than in nonsmoking miners. Based on an average mining experience of 15 years, there is substantial evidence that the present maximum allowable limit of 0.3 working levels (WL), or 4 working level months (WLM) per year, is safe, representing a margin of safety of approximately 10:1. Furthermore, a comparison of these data with the radon levels in some homes, averaging in the neighborhood of 0.025 WL, would indicate that health risks at these levels are negligible. It is suggested that 20 picocuries/liter, which equals 0.10 WL, be the maximum allowable level in homes.

journal_name

Cancer

journal_title

Cancer

authors

Saccomanno G,Huth GC,Auerbach O,Kuschner M

doi

10.1002/1097-0142(19881001)62:7<1402::aid-cncr2820

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

1402-8

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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