The culture of faith and hope: patients' justifications for their high estimations of expected therapeutic benefit when enrolling in early phase oncology trials.

abstract：BACKGROUND:The intraoperative evaluation of axillary sentinel lymph nodes (SLNs) allows the surgeon to complete axillary dissection in 1 setting at the time of the primary breast surgery. However, to the authors' knowledge, there is no consensus regarding the optimal method for intraoperative evaluation of SLNs in brea...

journal_title：Cancer

authors： Krishnamurthy S,Meric-Bernstam F,Lucci A,Hwang RF,Kuerer HM,Babiera G,Ames FC,Feig BW,Ross MI,Singletary E,Hunt KK,Bedrosian I

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Scarce data exist concerning the outcome of very elderly patients with head and neck squamous cell carcinoma (HNSCC). METHODS:The clinical files of 316 patients aged > or = 80 years with HNSCC who were included in the authors' hospital database between 1987 and 2006 were reviewed retrospectively. RESULTS:A...

journal_title：Cancer

authors： Italiano A,Ortholan C,Dassonville O,Poissonnet G,Thariat J,Benezery K,Vallicioni J,Peyrade F,Marcy PY,Bensadoun RJ

更新日期：2008-12-01 00:00:00

abstract：:During the period 1955 to 1975, 63 consecutive cases of apical lung carcinoma were treated in the Radiation Therapy Division of the University of Michigan Medical Center (UMMC). Supervoltage external radiation alone or combination of radiation and surgery were the main modalities of treatment used in these patients. O...

journal_title：Cancer

authors： Ahmad K,Fayos JV,Kirsh MM

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:The overexpression of HER-2 occurs in a minority of patients with nonsmall cell lung carcinoma. Trastuzumab, which is a monoclonal antibody to HER-2, is an effective treatment in some women with breast carcinomas that overexpress HER-2, as demonstrated by immunohistochemistry. The objective of this Phase II ...

journal_title：Cancer

authors： Clamon G,Herndon J,Kern J,Govindan R,Garst J,Watson D,Green M,Cancer and Leukemia Group B.

更新日期：2005-04-15 00:00:00

abstract：BACKGROUND:Atypia of undetermined significance is a controversial category in thyroid fine-needle aspiration (FNA), not only for its questioned clinical utility, but also for its very existence as an expression of uncertainty. The current study was performed to investigate the potential impact of eliminating this categ...

journal_title：Cancer

authors： Shi Y,Ding X,Klein M,Sugrue C,Matano S,Edelman M,Wasserman P

更新日期：2009-10-25 00:00:00

abstract：:Fever, clinical infection, bacteriologically documented infection, and death from infection were evaluated in 95 consecutive uninfected patients with severe granulocytopenia (less than 0.5 x 10(6)/liter). Patients were randomly allocated to reverse isolation and prophylactic oral nonabsorbable antibiotics or to open w...

journal_title：Cancer

authors： Ribas-Mundo M,Granena A,Rozman C

更新日期：1981-07-15 00:00:00

abstract：BACKGROUND:The prognosis of pediatric patients with nonpilocytic astrocytoma, and in particular those with anaplastic astrocytoma, is somewhat unpredictable. This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric as...

journal_title：Cancer

authors： Ho DM,Wong TT,Hsu CY,Ting LT,Chiang H

更新日期：1998-06-15 00:00:00

abstract：:A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...

journal_title：Cancer

authors： Wada A,Ishiguro S,Tateishi R,Ishikawa O,Matsui Y

更新日期：1983-05-15 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...

journal_title：Cancer

authors： Sidawy MK,Del Vecchio DM,Knoll SM

更新日期：1997-08-25 00:00:00

abstract：:Seventy-eight patients with metastatic cancer to the lungs underwent flexible fiberoptic bronchoscopy for diagnosis. The patients were divided into two groups by presenting radiographic pattern as: (I) diffuse linear interstitial infiltrations (55 patients); and (II) localized or multiple nodular opacities (23 patient...

journal_title：Cancer

authors： Chuang MT,Padilla ML,Teirstein AS

更新日期：1983-11-15 00:00:00

abstract：:Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...

journal_title：Cancer

authors： Offit K,Macris NT,Hellman G,Rotterdam HZ

更新日期：1986-01-15 00:00:00

abstract：:The breast pathology files at the Institut Gustave-Russy in Villejuif, France, were searched for papillary cystadenomas and papillary carcinomas diagnosed between January 1, 1960, and December 31, 1974. A total of 158 cases were selected for this study; they were subclassified into 74 papillary cystadenomas, 63 papill...

journal_title：Cancer

authors： Murad TM,Contesso G,Mouriesse H

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...

journal_title：Cancer

authors： Garrison LP Jr,Lalla D,Brammer M,Babigumira JB,Wang B,Perez EA

更新日期：2013-09-01 00:00:00

abstract：:Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirr...

journal_title：Cancer

authors： Sumithran E,Prathap K

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Recent advances in the early detection of prostatic adenocarcinoma have stimulated interest in the development of techniques for determining metastatic potential. METHODS:One hundred cases of adenocarcinoma, including 66 biopsy and radical prostatectomy specimens; 20 biopsies alone; and 14 transurethral res...

journal_title：Cancer

authors： Ross JS,Nazeer T,Church K,Amato C,Figge H,Rifkin MD,Fisher HA

更新日期：1993-11-15 00:00:00

abstract：BACKGROUND:The local control rates of T1 and T2 supraglottic carcinoma treated with radiation alone were reported as 71% to 92% and 59% to 83%, respectively. The factors that affect the local control rate for early supraglottic carcinoma were investigated. METHODS:From 1967 through 1985, 100 cases with early supraglot...

journal_title：Cancer

authors： Inoue T,Matayoshi Y,Inoue T,Ikeda H,Teshima T,Murayama S

更新日期：1993-07-01 00:00:00

abstract：:A solitary hepatic tumor in a 50-year-old woman, which was observed as a hemangioma, ultimately was resected because it increased in size. The tumor volume doubling time was 28.8 months over the observed period of 30 months. The histologic diagnosis was carcinoid tumor. Immunohistochemical staining showed strong focal...

journal_title：Cancer

authors： Moriura S,Ikeda S,Hirai M,Naiki K,Fujioka T,Yokochi K,Gotou S

更新日期：1993-09-01 00:00:00

abstract：:During the period from March 1963 through March 1978, 30 patients with malignant neoplasms of the paranasal sinuses were treated with supervoltage technique at the University of Rochester Medical Center. Twenty-one patients had at least the medial portion of the orbit within the effective treatment volume and the rest...

journal_title：Cancer

authors： Nakissa N,Rubin P,Strohl R,Keys H

更新日期：1983-03-15 00:00:00

abstract：:A number of problems inherent to quality of care evaluation have been described above. Although issues such as limited resources and clinical staff resistance may not be specific to cancer care, they certainly impact on the evaluation of the quality of care offered to cancer patients. Other issues such as complexity o...

journal_title：Cancer

authors： Miransky LJ

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:The goal of the current study was to investigate the prognostic impact of proliferative activity, together with the other classic clinicopathologic prognostic factors (tumor size, tumor grade, receptor status, ploidy, and lymph node status), in breast carcinoma by counting mitoses and evaluating S phase frac...

journal_title：Cancer

authors： Michels JJ,Marnay J,Delozier T,Denoux Y,Chasle J

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:In this report, the authors describe their collective experience with melphalan-based autotransplants since the inception of their program at the University of Arkansas for Medical Sciences in 1989. METHODS:The authors evaluated the clinical outcomes of 3077 successive patients with multiple myeloma (MM) wh...

journal_title：Cancer

authors： Pineda-Roman M,Barlogie B,Anaissie E,Zangari M,Bolejack V,van Rhee F,Tricot G,Crowley J

更新日期：2008-04-15 00:00:00

abstract：:Meningeal carcinomatosis can appear with a variety of neurologic signs and symptoms. Alterations in respiratory control have not been reported in this syndrome or in neurologic syndromes associated with systemic cancer. The authors report on a case of documented leptomeningeal carcinoma from breast cancer presenting a...

journal_title：Cancer

authors： Marcus FS,Dandolos EM,Friedman MA

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:The performance of cytologic screening and its correlation with histology and polymerase chain reaction (PCR) detection of human papillomavirus (HPV) DNA have not been evaluated in populations with a low prevalence of anal intraepithelial neoplasia (AIN). The objective of the current study was to analyze the...

journal_title：Cancer

authors： Etienney I,Vuong S,Si-Mohamed A,Fléjou JF,Atienza P,Bauer P,Cytological Diaconesses Group.

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...

journal_title：Cancer

authors： Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK

更新日期：2007-01-15 00:00:00

abstract：:Six patients with metastatic mixed germ-cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to h...

journal_title：Cancer

authors： Logothetis CJ,Samuels ML,Trindade A,Johnson DE

更新日期：1982-10-15 00:00:00

abstract：BACKGROUND:Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have a dismal prognosis and increased mortality. The few studies that have focused on the evaluation of prognostic factors in patients with LC have resulted in contradictory results. Thus, the tr...

journal_title：Cancer

authors： Bruna J,González L,Miró J,Velasco R,Gil M,Tortosa A,Neuro-Oncology Unit of the Institute of Biomedical Investigation of Bellvitge.

更新日期：2009-01-15 00:00:00

abstract：:The prognostic value of nuclear DNA content was studied retrospectively using flow cytometry in 203 cases of resected hepatocellular carcinoma. The occurrence of DNA aneuploidy, which was detected in 50% of patients, correlated significantly with tumor size and the presence of vascular invasion or intrahepatic metasta...

journal_title：Cancer

authors： Fujimoto J,Okamoto E,Yamanaka N,Toyosaka A,Mitsunobu M

更新日期：1991-02-15 00:00:00

abstract：:Neuroendocrine small cell carcinoma is a lethal, but rare, tumor that arises most frequently in the lung. Small cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fourth reported case of neuroendocrine small cell carcinoma of the vulva. Previously, small cel...

journal_title：Cancer

authors： Cliby W,Soisson AP,Berchuck A,Clarke-Pearson DL

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Systemic, high-dose interferon-alpha treatment given three times per week subcutaneously induces tumor regression in approximately 30% of patients with inoperable hepatocellular carcinoma (HCC). The objective of the current study was to determine the efficacy and safety of transcatheter arterial interferon e...

journal_title：Cancer

authors： Yuen MF,Ooi CG,Hui CK,Wong WM,Wong BC,Chan AO,Lai CL

更新日期：2003-06-01 00:00:00

abstract：:Peripheral B- and T-lymphocyte counts were studied in 50 patients before they received any therapy for their conditions: 16 had carcinoma of the breast; 8 soft tissue sarcoma; and 26, benign disease. Among 11 males, the six patients with advanced soft tissue sarcoma had significantly lower percentages of T lymphocytes...

journal_title：Cancer

authors： Lee YT,Marshall GJ,Weiner J,Bateman JR

更新日期：1977-08-01 00:00:00