Abstract:
BACKGROUND:Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have a dismal prognosis and increased mortality. The few studies that have focused on the evaluation of prognostic factors in patients with LC have resulted in contradictory results. Thus, the treatment of LC remains controversial, and no straightforward guidelines exist in the literature. The objective of the current study was to identify prognostic markers related to LC survival to better select patients who are eligible for intensive treatment.
METHODS:Seventy patients who had a diagnosis of LC were reviewed, and clinical data, cerebrospinal fluid (CSF) parameters, tumor-related characteristics, and treatment information were registered. The impact of single parameters on overall survival was determined by both univariate and multivariate analyses.
RESULTS:The multivariate analysis revealed that Radiation Therapy Oncology Group score
journal_name
Cancerjournal_title
Cancerauthors
Bruna J,González L,Miró J,Velasco R,Gil M,Tortosa A,Neuro-Oncology Unit of the Institute of Biomedical Investigation of Bellvitge.doi
10.1002/cncr.24041subject
Has Abstractpub_date
2009-01-15 00:00:00pages
381-9issue
2eissn
0008-543Xissn
1097-0142journal_volume
115pub_type
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