Abstract:
:With endometrial adenocarcinoma, several factors, such as stage and histologic grade, are well recognized as having prognostic significance. Other variables, e.g., nuclear grade, probably are also important clinically. A preliminary investigation of the prognostic value of the ploidy, cell cycle kinetics, and sex steroid receptor contents of these tumors has been conducted and compared with more conventional prognostic factors such as stage, grades, and depth of invasion. As analyzed by flow cytometry, the proliferative activities of the carcinomas were significantly associated with prognosis. Tumors with lower levels of proliferative activity were related to improved survivals. Two thirds of the carcinomas were diploid; ploidy did not carry prognostic weight in the series. Both the estrogen and progesterone receptor status were related to survival. Patients whose tumors were positive for these receptors had a better prognosis than did those in which the receptors were not present in significant quantities.
journal_name
Cancerjournal_title
Cancerauthors
Geisinger KR,Homesley HD,Morgan TM,Kute TE,Marshall RBdoi
10.1002/1097-0142(19861001)58:7<1518::aid-cncr2820subject
Has Abstractpub_date
1986-10-01 00:00:00pages
1518-25issue
7eissn
0008-543Xissn
1097-0142journal_volume
58pub_type
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