Endometrial adenocarcinoma. A multiparameter clinicopathologic analysis including the DNA profile and the sex steroid hormone receptors.

Abstract:

:With endometrial adenocarcinoma, several factors, such as stage and histologic grade, are well recognized as having prognostic significance. Other variables, e.g., nuclear grade, probably are also important clinically. A preliminary investigation of the prognostic value of the ploidy, cell cycle kinetics, and sex steroid receptor contents of these tumors has been conducted and compared with more conventional prognostic factors such as stage, grades, and depth of invasion. As analyzed by flow cytometry, the proliferative activities of the carcinomas were significantly associated with prognosis. Tumors with lower levels of proliferative activity were related to improved survivals. Two thirds of the carcinomas were diploid; ploidy did not carry prognostic weight in the series. Both the estrogen and progesterone receptor status were related to survival. Patients whose tumors were positive for these receptors had a better prognosis than did those in which the receptors were not present in significant quantities.

journal_name

Cancer

journal_title

Cancer

authors

Geisinger KR,Homesley HD,Morgan TM,Kute TE,Marshall RB

doi

10.1002/1097-0142(19861001)58:7<1518::aid-cncr2820

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

1518-25

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

58

pub_type

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