Systemic giant-cell histiocytosis: report of a case and a review of the adult form of Letterer-Siwe disease.

Abstract:

:The multiple classifications of histiocytic disorders, and the lack of specificity in their application, have degraded the utility of such diagnostic terms as "Letterer-Siwe Disease" and "Malignant Histiocytosis". A case is presented of a systemic histiocytic proliferation with erythrophagocytosis and giant-cell formation which does not fit into any presently accepted diagnostic niche. No similar case was found in the literature. Moreover, it appears that the entity "Adult form of Letterer-Siwe disease" has been uncritically accepted on the basis of a few poorly documented cases, and should be abandoned.

journal_name

Cancer

journal_title

Cancer

authors

Wolfson WL,Gossett T,Pagani J

doi

10.1002/1097-0142(197612)38:6<2529::aid-cncr282038

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

2529-37

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

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