Effectiveness of once weekly total skin electron beam therapy in mycosis fungoides and Sezary syndrome.

Abstract:

:During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median of 18 months (range 6-103 months). Although approximately 80 to 90% of the total population were in the advanced stages of the disease and had been previously treated elsewhere, cutaneous lesions and associated symptoms were effectively controlled. The remission lasted 6 to 103 months (median 19 months) after beginning the therapy for 109 mycosis fungoides patients, who were at risk for 12-103 months (median 24 months). Erythroderma and circulating Sezary cells adversely affected the duration of remission and indicate extracutaneous dissemination. Lymphocyte responsiveness to various mitogens and antigens correlated well with duration of the remission that was obtained from a course of TSEB.

journal_name

Cancer

journal_title

Cancer

authors

Nisce LZ,Safai B,Kim JH

doi

10.1002/1097-0142(19810301)47:5<870::aid-cncr28204

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

870-6

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

47

pub_type

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