Abstract:
BACKGROUND:It is hypothesized that oligometastatic disease represents a state of potentially curable, limited metastases. Stereotactic body radiation therapy (SBRT) is an option for patients who are not amenable to or do not want resection. METHODS:From 2001 to 2006, 121 patients with < or =5 detectable metastases were enrolled in 2 prospective studies that used curative-intent SBRT. Most patients were treated with 10 fractions of 5 Gray. Stereotactic radiosurgery was offered to patients with brain metastases. RESULTS:The 2-year overall survival (OS), progression-free survival (PFS), local control (LC), and distant control (DC) rates were 50%, 26%, 67%, and 34%, respectively; and the respective 4-year rates values were 28%, 20%, 60%, and 25%. A greater net tumor volume predicted significantly worse OS, PFS, LC, and DC. Patients with breast cancer fared significantly better with respect to OS, PFS, LC, and DC; and patients with adrenal metastases had significantly worse OS, PFS, and DC despite the small number of such patients enrolled. Neither the number of metastatic lesions nor the number of organs involved was a significant predictor of outcome. Among 45 patients who remained alive at the last follow-up, 29 patients had no evidence of disease, including 23 patients with > or =2 years of follow-up. CONCLUSIONS:Oligometastatic disease is a potentially curable state of distant cancer spread. In this hypothesis-generating analysis, patients with less volume burden of their metastatic disease and those with primary breast cancer fared better. SBRT delivered with curative intent in patients with limited metastases should be investigated further. The Southwest Oncology Group is developing a prospective protocol to treat women who have limited breast cancer metastases with SBRT.
journal_name
Cancerjournal_title
Cancerauthors
Milano MT,Katz AW,Muhs AG,Philip A,Buchholz DJ,Schell MC,Okunieff Pdoi
10.1002/cncr.23209subject
Has Abstractpub_date
2008-02-01 00:00:00pages
650-8issue
3eissn
0008-543Xissn
1097-0142journal_volume
112pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) has been used with variable success as a diagnostic test for benign and malignant breast lesions. The goal of this study was to examine the effects of training physicians in the fine-needle aspiration sampling-technique on the diagnostic accuracy of FNAB of palpable breas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9040
更新日期:2001-08-25 00:00:00
abstract:BACKGROUND:Ewing's sarcomas, osteosarcomas, and rhabdomyosarcomas are significantly more responsive to chemotherapy than other sarcomas. Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of children with locally advanced or metastatic tumors remain curable, few data exi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Tumor endothelium represents a valuable target for cancer therapy. The vasculature plays a critical role in the survival and continued growth of solid tumor masses; in addition, the inherent differences between tumor blood vessels and blood vessels associated with normal tissue make the tumor vasculature a u...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.20299
更新日期:2004-06-15 00:00:00
abstract::One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840615)53:12<2579::aid-cncr282
更新日期:1984-06-15 00:00:00
abstract:BACKGROUND:Poor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15-39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resourc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29669
更新日期:2015-12-15 00:00:00
abstract::We counted the number of toluidine blue positive mast cells within and around the tumor in 44 patients with soft tissue sarcomas (STS). Irrespective of their histologic types, these cases were broadly divided into the following two groups: (1) low count (less than 20 mast cells/10 high-power fields [HPF]) and (2) high...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881201)62:11<2416::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:To evaluate the immunologic activity of regional lymph nodes, the phenotype of lymphocytes and the functional expression of cell adhesion molecules (CAMs) on lymph node lymphocytes (LNL-: uninvolved, LNL+: involved) were investigated in patients with gastrointestinal carcinoma. METHODS:The lymphocyte subpop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19961015)78:8<1677::aid-cn
更新日期:1996-10-15 00:00:00
abstract::Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850915)56:6<1356::aid-cncr2820
更新日期:1985-09-15 00:00:00
abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract:BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21368
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Patients with metastatic melanoma (MM) have very few therapy options. Based on reports of responses to paclitaxel and carboplatin (PC), 31 patients with MM were treated with PC. METHODS:Data regarding patients treated with PC were abstracted from medical records. Clinical outcomes as determined by the treat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21611
更新日期:2006-01-15 00:00:00
abstract::Nine patients with mixed müllerian tumors (MMT) of the uterus associated with a history of prior pelvic irradiation were compared clinically and pathologically with 8 nonirradiation-associated MMT control patients. Patients with postirradiation tumors presented at a younger age and with symptoms indicative of extensiv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800401)45:7<1625::aid-cncr2820
更新日期:1980-04-01 00:00:00
abstract::In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This ar...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19931201)72:11+<3484::aid-cncr28
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Oral leukoplakia is a premalignant lesion, but the genetic changes in the foci of early cancerization in leukoplakia have not been studied. METHODS:Loss of heterozygosity (LOH) was successively investigated in 13 cases in the leukoplakia and foci of early cancerization in the same leukoplakia. The authors m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011101)92:9<2349::aid-cncr1582
更新日期:2001-11-01 00:00:00
abstract::We report on an 89-year-old female admitted with signs of intestinal obstruction in whom three independent adenocarcinomas of the proximal jejunum were found. Multiple foci of pyloric gland metaplasia, glandular hyperplasia and dysplasia, carcinoma-in-situ, and several varieties of adenocarcinoma were identified on mi...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197909)44:3<1142::aid-cncr282044
更新日期:1979-09-01 00:00:00
abstract::A hybrid radiofrequency heating system previously reported to produce highly focused heating patterns at less than or equal to 10 cm depth in phantom models was utilized to selectively heat hypervascular, heat resistant rabbit V-2 tumors implanted in the left hindlimb. Spheroidal heating patterns 3 to 4 cm in diameter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1172::aid-cncr2820
更新日期:1985-03-15 00:00:00
abstract:BACKGROUND:Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chemotherapy, more recent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25298
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The identification of the BRCA1 gene is a powerful tool for predicting a patient's lifetime risk for carcinoma of the breast and ovary when she has hereditary breast/ovarian carcinoma (HBOC) syndrome. The process of BRCA1 testing and genetic counseling and participants' reactions to test results, are describ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970601)79:11<2219::aid-c
更新日期:1997-06-01 00:00:00
abstract::Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1180::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract::A spontaneous complete remission of 34 months' duration was observed in an adult patient with acute myeloblastic leukemia. The remission occurred after a severe febrile pneumonia, which was treated with leukocyte transfusions. At relapse, chromosomal abnormalities reappeared slowly. Such spontaneous complete remission...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850901)56:5<1187::aid-cncr2820
更新日期:1985-09-01 00:00:00
abstract::The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810201)47:3<615::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. METHODS:A broad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32432
更新日期:2019-12-15 00:00:00
abstract::The clinical presentation of the disease and the results of treatment in 42 patients with malignant peripheral neuroectodermal tumors (MPNT) entered into the Cooperative Ewing's, soft tissue, and neuroblastoma trials of the German Society of Pediatric Oncology were retrospectively analyzed. Within the Ewing's sarcoma ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880115)61:2<349::aid-cncr28206
更新日期:1988-01-15 00:00:00
abstract::Plasma carcinoembryonic antigen (CEA) levels were studied in all available members of 17 families in which a presumed sporadic retinoblastoma had occurred. In 9 of the 17 families, close relatives of the patient had elevated CEA levels in the absence of demonstrable disease; this we have termed the "CEA family syndrom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1397::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::Twenty-one patients with bilateral Wilms' tumor are reviewed and the details of diagnosis, therapy, and survival presented. All patients had an abdominal mass at the time of diagnosis. Associated findings included hypertension, aniridia, and genitourinary anomalies. Favorable histologic features were found in all simu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851115)56:10<2524::aid-cncr282
更新日期:1985-11-15 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19991015)86:8<1590::aid-cn
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23507
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:Prognostic implications of overexpression of the HER-2 gene in nonsmall cell lung carcinoma (NSCLC) are a matter of controversy. Many conflicting results have been reported from different laboratories. METHODS:A metaanalysis of published studies was performed for this quantitative review of the effects of H...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.20957
更新日期:2005-05-01 00:00:00
abstract::Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<933::aid-cncr28205
更新日期:1987-03-01 00:00:00
abstract::A squamous cell carcinoma arising in intralobar bronchopulmonary sequestration of the right lower lobe is described in a 69-year-old man. One other reported case was found. Other complications of bronchopulmonary sequestration include nonspecific infections and tuberculosis. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197907)44:1<334::aid-cncr2820440
更新日期:1979-07-01 00:00:00