Abstract:
BACKGROUND:Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize; however, to the authors' knowledge there are limited data regarding the spread of disease through cerebrospinal fluid (CSF). METHODS:Eight of 200 consecutive patients (4%) with meningiomas manifested CSF dissemination. CSF cytology was positive in all patients, and neuroradiographic studies were consistent with CSF dissemination in eight patients. The patients (6 women and 2 men) ranged in age from 24-87 years (mean age, 52 years). All patients had undergone prior surgery (range, one to five surgeries; median, two surgeries), radiotherapy (involved-field radiotherapy in seven patients and stereotactic radiotherapy in six patients), and chemotherapy (hydroxyurea in eight patients). Multiple sites of metastases were seen in all patients and were both within the nervous system (subarachnoid or ventricular tumor: intracranial in eight patients, spinal cord in four patients) and extraneural (subcutaneous, cervical lymph nodes, orbit, or pulmonary in five patients). Treatment utilized both systemic chemotherapy (temozolomide in four patients, irinotecan in three patients, hydroxyurea in three patients, interferon-alpha in two patients, and doxorubicin plus ifosfamide in one patient) and intraventricular chemotherapy (liposomal cytosine arabinoside in seven patients, thiotepa in one patient, and busulfan in one patient). RESULTS:Treatment-related toxicity was seen in eight patients, including chemical meningitis in eight patients (Grade 2), neutropenia in five patients (Grade 2 in four patients and Grade 3 in one patient), fatigue in one patient (Grade 2), and gastrointestinal toxicity in one patient (Grade 2). The best response was stable disease in seven patients and progressive disease in one patient. The response duration ranged from 2-31 months (median, 3.5 months). The median survival was 5.5 months, and 3 patients were alive with disease at the time of last follow-up. CONCLUSIONS:The treatment of CSF-disseminated meningioma, although feasible and comparatively nontoxic, was associated with modest outcomes despite combined systemic and intraventricular chemotherapy.
journal_name
Cancerjournal_title
Cancerauthors
Chamberlain MC,Glantz MJdoi
10.1002/cncr.20926subject
Has Abstractpub_date
2005-04-01 00:00:00pages
1427-30issue
7eissn
0008-543Xissn
1097-0142journal_volume
103pub_type
杂志文章相关文献
CANCER文献大全abstract::A retrospective study was made of the surgical treatment of distant metastases from melanoma in 143 patients. The determinants of survival benefit were: (1) successful complete resection of all clinical disease; (2) single versus multiple metastatic site; and (3) anatomic location of disease. Complete resection was ac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850901)56:5<1222::aid-cncr2820
更新日期:1985-09-01 00:00:00
abstract::Correlations of c-erbB-2 protein expression with clinical outcomes of gastric carcinomas were studied in 189 gastric carcinomas. There were 23 (12.2%) carcinomas with evidence of c-erbB-2 protein in which the reaction was localized to the cell membrane. There was no significant association between c-erbB-2 staining an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910601)67:11<2914::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract::The records of 314 children with acute lymphocytic leukemia (ALL) were reviewed to determine the frequency, clinical and laboratory features; contributing factors; and prognosis of cyclophosphamide-induced hemorrhagic cystitis. Twenty-five well-documented cases of hemorrhagic cystitis were identified. While most of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197511)36:5<1572::aid-cncr282036
更新日期:1975-11-01 00:00:00
abstract::Chemotherapy for tumors of the central nervous system has a limited efficacy presumably because of restricted blood-brain barrier permeability. The advantage of regional intra-arterial administration of anticancer drugs is an increased uptake during the first passage of the drugs through tumor capillaries. Twenty pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910601)67:11<2844::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Treatment of localized prostate carcinoma (LPC) using radiotherapy (RT) can induce disturbances in a patient's quality of life (QOL) and urinary and intestinal function. Late symptoms and QOL were evaluated in a randomized trial between RT and deferred treatment (DT). METHODS:Quality of life was evaluated w...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20011215)92:12<3111::aid-cncr101
更新日期:2001-12-15 00:00:00
abstract::A case of basosquamous or so-called transitional cloacogenic carcinoma of the sigmoid colon, which arose above the pelvic brim at the peritoneal reflection, is reported. We were not able to find a report of this histologic type of tumor arising this far from the pectinate line of the anus, which is the most common pri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197709)40:3<1234::aid-cncr282040
更新日期:1977-09-01 00:00:00
abstract::Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881015)62:1+<1823::aid-cncr282
更新日期:1988-10-15 00:00:00
abstract::A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum prot...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2295::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract:BACKGROUND:This qualitative study investigated the medical decision-making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision-making involvement. METHODS:Interviews were conducted with 40 adolescents between...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29663
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Salivary gland carcinomas (SGCs) are a rare malignancy with unknown etiology. The objective of the current study was to identify genetic variants modifying the risk of SGC and its major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma. METHODS:The authors conducted a genome-wide association s...
journal_title:Cancer
pub_type: 杂志文章,收录出版
doi:10.1002/cncr.29381
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30881
更新日期:2017-12-15 00:00:00
abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:From 1973 to 1991, the incidence of kidney cancer in the United States increased by 35.4%. METHODS:A multicenter, hospital-based case-control study was conducted from 1977 to 1993 through an interview of 788 patients with renal cell carcinoma and 779 control subjects. RESULTS:Compared with those who never ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19950515)75:10<2552::aid-cncr282
更新日期:1995-05-15 00:00:00
abstract:BACKGROUND:Cervical cancer mortality rates have declined in the United States, primarily because of Papanicolaou testing. However, limited information is available about the incidence of the disease in the US-Mexico border region, where some of the poorest counties in the United States are located. This study was under...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23748
更新日期:2008-11-15 00:00:00
abstract::Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860715)58:2+<473::aid-cncr2820
更新日期:1986-07-15 00:00:00
abstract:BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10260
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Radiation recall is a recurrence of acute toxicity within a previously quiescent radiation field that occurs with subsequent administration of chemotherapy. METHODS:A patient with acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma (KS) who had radiation recall is reported. The patient was par...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19930215)71:4<1322::aid-cncr2820
更新日期:1993-02-15 00:00:00
abstract::Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intratheca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Malnutrition is a common complication of cancer treatment; it can affect energy levels and, as a consequence, quality of life. The goal of the current study was to evaluate the effect of dietetic intervention in a cohort of children treated for medulloblastoma and supratentorial primitive neuroectodermal tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11598
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22241
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Despite growing evidence and support for shared decision making, little is known about the experiences of parents who hold more active roles than they wish. METHODS:This was a prospective cohort study of 372 parents of children with cancer and their oncologists at 2 academic pediatric hospitals. Parents wer...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31939
更新日期:2019-04-15 00:00:00
abstract::Carcinoma of the breast is a disease that is associated with 10-year recurrence rates of 25% in operable patients with no spread to the axillary nodes and 75% in patients in whom the tumor has extended to the axillary nodes. Locoregional recurrence rates of close to 50% have been reported in patients with Stage III di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820741334
更新日期:1994-07-01 00:00:00
abstract::Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leuke...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197902)43:2<718::aid-cncr2820430
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710214
更新日期:1993-01-15 00:00:00
abstract::Three cases of peritoneal papillary serous carcinoma with a complete response to chemotherapy and long-term disease free survival are reported. All three patients presented with multifocal or diffuse peritoneal involvement. Microscopic ovarian serosal surface involvement was demonstrated in two cases. The ovaries were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860915)58:6<1371::aid-cncr2820
更新日期:1986-09-15 00:00:00
abstract:BACKGROUND:Several histologic classifications of thymomas have been proposed, and attempts have been made to correlate the different histologic subtypes to clinical behavior and prognosis. Recently, Marino and Müller-Hermelink and Kirchner et al. proposed a new morphologic classification of thymomas based on the resemb...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940715)74:2<606::aid-cncr28207
更新日期:1994-07-15 00:00:00
abstract:BACKGROUND:Clear cell sarcoma (CCS) of tendons and aponeuroses is extremely rare in childhood and little information is available on its clinical management. Originally believed to be a type of melanoma of soft tissue origin, CCS is now considered a distinct clinicopathologic entity that behaves like a high-grade soft ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10597
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30163
更新日期:2016-10-01 00:00:00
abstract::Spleen from nine patients with hairy-cell leukemia (HCL) were studied for ultrastructural alterations. In all cases, hairy cells with typical ultrastructural characteristics were observed within splenic cords and sinuses. Hairy cells had numerous cytoplasmic processes that interdigitated with cytoplasmic processes of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820415)49:8<1617::aid-cncr2820
更新日期:1982-04-15 00:00:00
abstract::Bacteria-antibody complexes were used to study capping of receptors for the activated third component of complement on peripheral blood lymphocytes. The impairment of C3d receptor capping improves in patients with chronic lymphocytic leukemia responding to therapy, but this does not necessarily correspond to the fall ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1538::aid-cncr2820
更新日期:1985-10-01 00:00:00