Abstract:
:Chemotherapy for tumors of the central nervous system has a limited efficacy presumably because of restricted blood-brain barrier permeability. The advantage of regional intra-arterial administration of anticancer drugs is an increased uptake during the first passage of the drugs through tumor capillaries. Twenty patients with high-grade astrocytomas (HGA) and 28 patients with metastatic brain tumors (MBT) received intracarotid/intravertebral infusion of etoposide and cisplatin. Eight patients with HGA who underwent incomplete resection responded to chemotherapy alone. Four additional patients had complete resection of the tumor. Median survival time of the group (responders and nonresponders) has been 14 months. Twelve patients with MBT responded to chemotherapy alone (six had complete response [CR], and six had partial response [PR]) with a median survival time of 7 months. Intra-arterial chemotherapy (IAC) appears to be effective with acceptable toxicities. Accrual of additional patients is required before a final conclusion can be reached.
journal_name
Cancerjournal_title
Cancerauthors
Madajewicz S,Chowhan N,Iliya A,Roque C,Beaton R,Davis R,Fertman S,Meek A,Alvarez O,Pampati Mdoi
10.1002/1097-0142(19910601)67:11<2844::aid-cncr282subject
Has Abstract,Author List Incompletepub_date
1991-06-01 00:00:00pages
2844-9issue
11eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Mortality from invasive bladder cancer is common, even with high-quality care. Thus, the best opportunities to improve outcomes may precede the diagnosis. Although screening currently is not recommended, better medical care of patients who are at risk (ie, those with hematuria) has the potential to improve o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25310
更新日期:2010-11-15 00:00:00
abstract::To investigate the possible role of sex-hormone imbalance in hepatocellular carcinogenesis in male alcoholic cirrhotic patients, we determined plasma levels of testosterone (T), dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone (DHA), estrone (E1), estradiol (E2), and sex-hormone-binding globulin ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880815)62:4<760::aid-cncr28206
更新日期:1988-08-15 00:00:00
abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract::Data on patients with gallbladder cancer listed in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed. Between 1977 and 1986, 3038 patients were recorded in the Program. Histologic grade, histologic type, stage of disease, and vascular invasion were correlated...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920915)70:6<1493::aid-cncr2820
更新日期:1992-09-15 00:00:00
abstract::Renal cell carcinoma (RCC) evokes an immune response, which occasionally has resulted in spontaneous and dramatic remissions. In an attempt to reproduce or accentuate this response, various immunotherapeutic strategies have been studied. The most consistent antitumor activity has been reported with interferon-alpha (I...
journal_title:Cancer
pub_type: 杂志文章,收录出版,评审
doi:10.1002/cncr.24236
更新日期:2009-05-15 00:00:00
abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Patients who have aggressive, refractory or recurrent non-Hodgkin lymphomas (NHLs) that are refractory to first-line anthracycline-containing regimens (ACRs) have a dismal outcome. Achieving complete remission (CR) is essential for a favorable outcome. To improve the CR rate in these patients, the authors de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21150
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:To define the clinicopathologic and prognostic features of patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) in North America, standard criteria were used to identify patients with ATLL. METHODS:Statistical analyses used included descriptive stati...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25147
更新日期:2010-07-15 00:00:00
abstract:BACKGROUND:Modern cancer treatments can cure or prolong patients' lives. However, the associated physical and psychosocial problems can detrimentally affect patients' compliance with treatment and, ultimately, their outcomes. Therefore, oncologists need to recognize the problems experienced by their patients and, when ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters. METHODS:A total of 170 patients with...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.21792
更新日期:2006-04-15 00:00:00
abstract:BACKGROUND:Previous Phase II trials evaluating paclitaxel as a single agent have produced objective response rates of 38-40%. However, in these studies patients had recurrent disease and had received previous treatment with chemotherapy, radiation, surgery, or some combination of the same. To the authors' knowledge, th...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001215)89:12<2587::aid-cncr11>
更新日期:2000-12-15 00:00:00
abstract::Bacteria-antibody complexes were used to study capping of receptors for the activated third component of complement on peripheral blood lymphocytes. The impairment of C3d receptor capping improves in patients with chronic lymphocytic leukemia responding to therapy, but this does not necessarily correspond to the fall ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1538::aid-cncr2820
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:The association between high procedure volume and lower perioperative mortality is well established among cancer patients who undergo cystectomy. However, to the authors' knowledge, the association between volume and perioperative complications has not been studied to date and hospital characteristics contri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21273
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The aim of this retrospective study was to determine those prognostic factors associated with response to a second-line chemotherapy in patients with metastatic breast carcinoma (MBC) that was previously responsive to a first-line chemotherapy. METHODS:The 70 MBC patients studied had previously responded to...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic tumors, one had a posterior fos...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<580::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820615)49:12<2455::aid-cncr282
更新日期:1982-06-15 00:00:00
abstract::A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<387::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3+<1139::aid-cncr282
更新日期:1994-08-01 00:00:00
abstract::Between February 1983 and February 1986, 132 patients with advanced urothelial tract tumors were treated with methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Analysis of prognostic factors for survival of the first 92 patients was undertaken using the Cox proportional hazards m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910315)67:6<1525::aid-cncr2820
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavil...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31892
更新日期:2019-04-01 00:00:00
abstract::In certain experimental tumor models, tumor growth is less pronounced in immune deficient animals. Characteristically, tumors such as the murine B16 melanoma and Lewis lung carcinoma (3LL) are weakly antigenic. We proposed that with such tumors that are weakly antigenic, growth is enhanced by T-cell factors. Young mic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1792::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas of the hand and foot present unique management challenges. The purpose of the current study study was to determine oncologic outcome, particularly with respect to factors affecting local recurrence, distant recurrence, and disease-specific survival. METHODS:A retrospective study was per...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10750
更新日期:2002-08-15 00:00:00
abstract:BACKGROUND:Sentinel lymph node (SLN) sampling is used to predict axillary lymph node (AxLN) metastasis in patients with breast carcinoma; AxLN sampling can be avoided in SLN-negative patients. Multistep sectioning and immunohistochemistry are reported to increase the sensitivity of micrometastasis detection. The author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11689
更新日期:2003-10-15 00:00:00
abstract:BACKGROUND:There is no consistent definition at what age patients with non-Hodgkin lymphoma (NHL) are considered "elderly." This might hamper well balanced decisions with respect to treatment. METHODS:From a population-based NHL registry the age groups younger than 60 years, 60-64 years, 65-69 years, 70-74 years, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001215)89:12<2667::aid-cncr21>
更新日期:2000-12-15 00:00:00
abstract:BACKGROUND:In vitro studies have shown an antiproliferative effect of tumor necrosis factor (TNF) against various nonsmall cell lung carcinoma (NSCLC) cell lines. However, clinical trials of combined interleukin-2 and TNF-alpha in patients with advanced NSCLC have demonstrated both conflicting and disappointing results...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:Several studies have demonstrated that abnormal levels of nuclear matrix protein 22 (NMP22) are associated with bladder cancer and have led to the approval of NMP22 as a urinary biomarker by the US Food and Drug Administration. Nonetheless, the clinical significance of NMP22 remains unclear. The objective of...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25903
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma. METHODS:To elucidate its clinicopathologic and genetic features, the authors studied 71 adult patients (median age, 57 years), including 22 patients who were ide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20625
更新日期:2004-11-15 00:00:00
abstract::The establishment and characterization of 11 human lung cancer cell lines are described in this article. Nine of these cell lines were established over a 5-year period, from 1983 to 1988, from patients treated at the Kingston Regional Cancer Centre. These include eight definite or probable small cell lung cancer (SCLC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920415)69:8<2064::aid-cncr2820
更新日期:1992-04-15 00:00:00
abstract:BACKGROUND:Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS:Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26034
更新日期:2011-09-15 00:00:00
abstract:BACKGROUND:Skin cancer affects more Americans than any other type of cancer. Children are prime targets for prevention education, because sun overexposure in early childhood may affect the development of skin cancer later in life. Preventive behaviors adopted early in life may be less resistant to change than those acq...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19950115)75:2+<651::aid-cncr2820
更新日期:1995-01-15 00:00:00