Abstract:
BACKGROUND:Previous Phase II trials evaluating paclitaxel as a single agent have produced objective response rates of 38-40%. However, in these studies patients had recurrent disease and had received previous treatment with chemotherapy, radiation, surgery, or some combination of the same. To the authors' knowledge, the study reported here is the first to examine the role of paclitaxel in affecting objective antitumor response, as a single agent, in a previously untreated patient population. METHODS:Patients with untreated, resectable, advanced squamous cell carcinoma of the head and neck were eligible for this Phase II trial. The treatment plan included paclitaxel 250 mg/m(2) administered by 24-hour intravenous infusion every 21 days for a total of 3 courses and primary prophylaxis with colony stimulating factor during each course of chemotherapy. Surgical resection was performed after recovery from the final course of chemotherapy. After adequate wound healing, patients received external beam radiotherapy (median dose to primary site, 55.8 Gray [Gy]; median dose to neck sites, 50.4 Gy). RESULTS:Forty-five patients were registered. Thirty-eight patients completed the planned chemotherapy, 41 patients underwent surgical resection, and 37 patients completed the intended radiotherapy. The objective response rate was 50% (10% complete response; 40% partial response). Severe or life-threatening (Grade 3 or higher) granulocytopenia or thrombocytopenia occurred in 78% and 27% of patients, respectively. Two patients died of sepsis. Seventy-one percent, 67%, and 91% of patients were free of local, lymph node, and distant recurrence, respectively, with a median follow-up of 37 months. The 4-year overall survival and disease-related survival rates were 44.4% and 52.9%, respectively. CONCLUSION:The authors conclude that paclitaxel is an active agent in patients with advanced head and neck carcinoma. However, the overall disease control, achieved by using paclitaxel as induction therapy, did not appear to be better than that achieved with standard treatment methods. Combined modality regimens with concurrent chemotherapy and radiotherapy have demonstrated more promise.
journal_name
Cancerjournal_title
Cancerauthors
Grecula JC,Smith RE,Rhoades CA,Sharma P,Agrawal A,Zhang H,Allen J,Goldman FP,Young D,Schuller DEdoi
10.1002/1097-0142(20001215)89:12<2587::aid-cncr11>subject
Has Abstractpub_date
2000-12-15 00:00:00pages
2587-96issue
12eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20001215)89:12<2587::AID-CNCR11>journal_volume
89pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Immediate or early postmastectomy breast reconstruction is performed infrequently. To the authors' knowledge, little is known regarding surgeon or patient perspectives on reconstruction treatment decisions. The purpose of the current study was to identify patient attitudes and preferences associated with bre...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21444
更新日期:2005-12-01 00:00:00
abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.2820741314
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Although several refinements have been reported for breast magnetic resonance imaging (MRI), there has been no uniform agreement by researchers on the optimal method. The authors report a simple and effective MRI method that incorporated the best qualities of other breast MRI methods yet eliminated the compl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010801)92:3<471::aid-cncr1345>
更新日期:2001-08-01 00:00:00
abstract::In January, 1972, the Southwest Oncology Group initiated two randomized studies for patients with advanced breast cancer. The study for patients with prior chemotherapy showed a 33% response rate with adriamycin. The study for patients without previous chemotherapy consisted of three treatment regimens; a weekly repea...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197607)38:1<13::aid-cncr28203801
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) with t(6;11)(q27;q23) is a well established but rare entity, and few studies have reported the full clinical, hematologic, and outcome data of patients with this disease. METHODS:To characterize the features of t(6;11) AML, the authors searched the Cancer and Leukemia Group B (C...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.20489
更新日期:2004-09-15 00:00:00
abstract::Patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of T cells, Fc receptor cells, and in derangements of T lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of develop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197907)44:1<117::aid-cncr2820440
更新日期:1979-07-01 00:00:00
abstract::Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:The appearance of p53 mutations in colorectal carcinoma was determined, independent of differentiation and tumor stage of the primary tumors, in relation to the survival of patients who were scheduled to undergo liver resection. METHODS:Tumor material was analyzed for p53 mutations in primary colorectal tum...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-02-15 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Epithelioid sarcoma is an uncommon tumor characterized by its appearance in the distal extremities (especially the forearm, wrist, and ankle), the tendency to recur locally, and high probability of spread to regional lymph nodes. Most patients have been treated surgically, and the potential role of radiation therapy a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<1022::aid-cncr2820
更新日期:1983-09-15 00:00:00
abstract::An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4072::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract::The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<353::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::The authors found metastases to the heart in 10.7% of 1029 autopsy cases in which a malignant neoplasm was diagnosed. The lung was the commonest primary site (36.4%) and adenocarcinoma was the most frequent cell type (36.4%) of neoplasms metastatic to heart. Nonepithelial tumors accounted for 22.7% of cardiac metastas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900315)65:6<1456::aid-cncr2820
更新日期:1990-03-15 00:00:00
abstract::A primary fibrosarcoma of the thyroid occurring in a patient with a nodular goiter is described. Light microscopy showed interwoven bundles of spindle cells admixed with plump ovoid cells, and foci of multinucleated giant cells. Remnants of distorted thyroid follicles were found only at the periphery of the tumor. "Tr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197908)44:2<584::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract::Late side effects of chemotherapy were studied in 51 women who had received at least 300 mg of melphalan for ovarian cancer and had survived for at least three years. Hematologic, statistical, and cytogenetic methods were employed. Six cases of iatrogenic leukemia were found. They appeared to represent a hematologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820601)49:11<2234::aid-cncr282
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:The unusual clinical picture of transitional cell carcinoma (TCC) in Taiwan appears to be different from that reported elsewhere. METHODS:The authors reviewed their experience of 135 cases of pathologically proven TCC of the upper urinary tract. Data regarding the gender ratio and clinical presentation were...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-03-15 00:00:00
abstract::To additionally understand the molecular mechanisms and biologic indicators of colonic tumorigenesis through the adenoma-carcinoma sequence, protein kinase C (PKC) activity was examined in the cytosol and particulate fraction of specimen homogenates from 18 human colonic carcinomas and seven coexisting colonic adenoma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<24::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:BRAF inhibitors are effective in melanoma and other cancers with BRAF mutations; however, patients ultimately develop therapeutic resistance through the activation of alternative signaling pathways such as RAF/RAS or MET. The authors hypothesized that combining the BRAF inhibitor vemurafenib with either the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33242
更新日期:2021-02-01 00:00:00
abstract::Five hundred and sixty-six patients with either Stage III or IV Hodgkin's disease were prospectively randomized to test whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine with procarbazine and prednisone. The combination of CCNU, vinblastine, procarbazine, and prednisone (CVPP) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800815)46:4<654::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract::Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL-N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1748::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960801)78:3<383::AID-CNC
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk METHODS:This was a retr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25013
更新日期:2010-04-15 00:00:00
abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract::Data on patients with gallbladder cancer listed in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed. Between 1977 and 1986, 3038 patients were recorded in the Program. Histologic grade, histologic type, stage of disease, and vascular invasion were correlated...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920915)70:6<1493::aid-cncr2820
更新日期:1992-09-15 00:00:00
abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207
更新日期:1995-09-15 00:00:00
abstract::The authors report the accuracy of mammographically guided fine-needle aspiration (FNA) for the diagnosis of nonpalpable breast lesions in a series of 71 patients. Each mammographically guided FNA was immediately followed by hookwire localization and open biopsy. Seven malignancies were identified cytologically, but t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<2007::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract::The natural history of the development of neoplasia in experimental systems may be separated into at least three different stages, those of initiation, promotion and progression. Evidence for such distinct stages has been demonstrated in at least half a dozen different experimental systems. The stage of promotion is t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1206::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract::The clinical and pathologic characteristics of 17 small carcinomas (less than 2 cm in diameter) of the pancreas are reviewed in this article. All the tumors were located in the head of the pancreas, and the clue to the diagnosis was jaundice in ten patients and abdominal pain in seven. Carcinoembryonic antigen (CEA) a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880701)62:1<135::aid-cncr28206
更新日期:1988-07-01 00:00:00
abstract::The physician must suspect pancreatic cancer in patients older than age 40 years who present with minimal vague symptoms. The presence of common disorders such as gallstones, hiatal hernia and diverticulosis coli, does not exclude pancreatic cancer. Ultrasonography, computed tomography, ERCP and cytology are the essen...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00